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  1. 4781
    por Gorodkin, Jan, Hofacker, Ivo L.
    Publicado 2011
    “…Computational methods were developed early for folding and prediction of RNA structure with the aim of assisting in functional analysis. With the discovery of more and more ncRNAs, it has become clear that a large fraction of these are highly structured. …”
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    From Structure Prediction to Genomic Screens for Novel Non-Coding RNAs
  2. 4782
    “…Here, we combined novel strategies of computational sequence analyses with in vivo functional analysis to establish a TF network model of coordinate myelin-associated gene transcription. …”
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    Towards resolving the transcription factor network controlling myelin gene expression
  3. 4783
    “…One of these proteins, GlnK2 was recently found to be incapable of binding 2-OG, and in order to understand the implications of this finding we conducted a detailed structural and functional analysis of a second GlnK protein from A. fulgidus, GlnK3. …”
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    Mechanism of Disruption of the Amt-GlnK Complex by P(II)-Mediated Sensing of 2-Oxoglutarate
  4. 4784
    “…This was further confirmed by the functional analysis of p56 mutants unable to assemble into dimers. …”
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    Novel dimeric structure of phage ϕ29-encoded protein p56: insights into uracil-DNA glycosylase inhibition
  5. 4785
    “…The expression changes of these genes were validated by quantitative real-time PCR and further functional analysis of these candidate genes and other genes also expected to control tracheal tube size revealed at least a partial explanation of Ttk's role in tube size regulation. …”
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    Tramtrack Is Genetically Upstream of Genes Controlling Tracheal Tube Size in Drosophila
  6. 4786
    “…In the present study, genome reduction is studied from a systems biology perspective through the reconstruction and functional analysis of genome-scale metabolic networks of S. glossinidius. …”
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    Metabolic Networks of Sodalis glossinidius: A Systems Biology Approach to Reductive Evolution
  7. 4787
    “…By using a functional assay, the Functional Analysis of Separated Alleles in Yeast (FASAY), the present study depicts the mutational pattern of TP53 in normal human fibroblasts after in vitro exposure to well-known carcinogens: benzo[a]pyrene, aflatoxin B(1) and acetaldehyde. …”
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    Benzo[a]pyrene, Aflatoxine B(1) and Acetaldehyde Mutational Patterns in TP53 Gene Using a Functional Assay: Relevance to Human Cancer Aetiology
  8. 4788
    “…RESULTS: Significantly increased IMT was observed in male carriers of the minor C (N) allele compared to GC and GG (KN and KK) genotype. Functional analysis on macrophages suggested a decreased association to Ox-LDL in NN carriers compared to KN and KK carriers which is also associated with a reduced OLR1 mRNA expression. …”
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    Association between OLR1 K167N SNP and Intima Media Thickness of the Common Carotid Artery in the General Population
  9. 4789
    “…The primary sequence analysis of 3333 non-redundant sequences showed that the GC percentage was 42.7 and the sequence length ranged from 101 – 2576 nucleotides. Further, functional analysis (Blast, Interproscan, Gene ontology and KEGG search) were executed and 1230 orthologous genes were annotated. …”
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    Analysis of expressed sequence tags (ESTs) from cocoa (Theobroma cacao L) upon infection with Phytophthora megakarya
  10. 4790
    “…This review presents data on genetic and functional analysis of some of the HIV-1 genes derived from HIV-1 infected individuals from north India (Delhi, Punjab and Chandigarh). …”
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    Genetic architecture of HIV-1 genes circulating in north India & their functional implications
  11. 4791
    “…In this study, we finished the functional analysis of MLC1 mutations identified recently in Chinese patients, including five newly described missense mutations (R22Q, A32V, G73E, A275T, Y278H), one known nonsense mutation (Y198X), and two known missense mutations (S69L, T118M). …”
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    Functional Studies of MLC1 Mutations in Chinese Patients with Megalencephalic Leukoencephalopathy with Subcortical Cysts
  12. 4792
    “…Finally, the proposed method was further validated against four publicly available metagenomes, including a highly complex Antarctic whale-fall bone sample, which was previously assumed to be too complex for binning prior to functional analysis.…”
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    Unsupervised discovery of microbial population structure within metagenomes using nucleotide base composition
  13. 4793
    “…Furthermore, knockdown of PPARA by small interfering RNA (siRNA) inhibited HBV replication similar to levels observed for miR-141. Promoter functional analysis indicated that repression of HBV replication by miR-141 mimics or siRNA was mediated by interfering with the HBV promoter functions, consistent with previous studies demonstrating that PPARA regulated HBV gene expression through interactions with HBV promoter regulatory elements. …”
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    MicroRNA-141 Represses HBV Replication by Targeting PPARA
  14. 4794
    “…Phototransduction-related genes as well as opsin genes were up-regulated in those cells. Functional analysis; i.e. patch clamp recordings, clearly revealed that generated photoreceptor cells, induced by CRX, RX and NEUROD, responded to light. …”
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    Derivation of Human Differential Photoreceptor-like Cells from the Iris by Defined Combinations of CRX, RX and NEUROD
  15. 4795
    por Saini, Nidhi, Reichert, Heinrich
    Publicado 2012
    “…Identification of novel candidate genes that control neuroblast self-renewal and differentiation as well as functional analysis of these genes in normal and tumorigenic conditions in a tissue-specific manner is now possible through genome-wide transgenic RNAi screens. …”
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    Neural Stem Cells in Drosophila: Molecular Genetic Mechanisms Underlying Normal Neural Proliferation and Abnormal Brain Tumor Formation
  16. 4796
    “…To assess the suitability of these methods for the functional analysis of the soil metaproteome, they were applied to a potting soil high in organic matter and a forest soil. …”
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    Soil metaproteomics – Comparative evaluation of protein extraction protocols
  17. 4797
    “…‘Promoter swapping’ is a powerful approach for the functional analysis of proteins in gametocytes (and beyond) that are essential during asexual blood-stage development.…”
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    Experimentally controlled downregulation of the histone chaperone FACT in Plasmodium berghei reveals that it is critical to male gamete fertility
  18. 4798
    “…By means of positional cloning and functional analysis techniques, we here show that insulin-like growth factor 1 receptor (IGF1R) can possibly mediate susceptibility to mastitis through autophagy. …”
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    Variant in the 5′ Untranslated Region of Insulin-Like Growth Factor 1 Receptor Is Associated With Susceptibility to Mastitis in Cattle
  19. 4799
    “…In addition, the lists of up-regulated and down-regulated genes were investigated by means of bioinformatics functional analysis, which allowed for the identification of biological processes affected by thalidomide. …”
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    A framework to identify gene expression profiles in a model of inflammation induced by lipopolysaccharide after treatment with thalidomide
  20. 4800
    por Burman, Luke G., Mauro, Vincent P.
    Publicado 2012
    “…Mutations were identified that confer resistance to pactamycin, allowing functional analysis of 40S ribosomal subunits containing synthetic 18S rRNAs by selectively blocking translation from endogenous (pactamycin-sensitive) subunits. rRNA constructs were suitably expressed in transfected cells, shown to process correctly, incorporate into ≈15% of 40S subunits, and function normally based on various criteria. …”
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    Analysis of rRNA processing and translation in mammalian cells using a synthetic 18S rRNA expression system
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