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  1. 4801
    “…A single copy of Czlcy-e was found in C. zofingiensis. Functional analysis by heterologous complementation in Escherichia coli showed the ability of this protein to convert lycopene to δ-carotene. …”
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    Isolation and Characterization of a Lycopene ε-Cyclase Gene of Chlorella (Chromochloris) zofingiensis. Regulation of the Carotenogenic Pathway by Nitrogen and Light
  2. 4802
    “…This study provides a basis for further functional analysis and characterization of annexin multigene families in the plant lineage.…”
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    Genome-wide Comparative Analysis of Annexin Superfamily in Plants
  3. 4803
    “…Microarray data were validated by quantitative polymerase chain reaction. Functional analysis revealed that the dysregulated genes in DS were significantly enriched in two and six KEGG pathways in N and C group, respectively. …”
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    Genome-Wide Expression Analysis in Down Syndrome: Insight into Immunodeficiency
  4. 4804
    “…We identified 84 candidate genes that are potentially up- or downregulated in response to innervation. By systematic functional analysis, we found that one of the downregulated genes, longitudinals lacking (lola), which encodes a BTB-Zn-finger transcription factor, is required for proper expression of glutamate receptors. …”
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    Lola regulates glutamate receptor expression at the Drosophila neuromuscular junction
  5. 4805
    “…The derived HCC networks were verified by functional analysis and network enrichment analysis. Furthermore, it was shown that the modularity and network rewiring in the HCC networks can clearly characterize the dynamic patterns of HCC progression.…”
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    Reconstructing dynamic gene regulatory networks from sample-based transcriptional data
  6. 4806
    “…Analysis of biopsies from asymptomatic viruria patients resulted in the identification of 5 differentially expressed genes (CD3E, CD68, CCR2, ICAM-1, and SKI) (P < 0.05), and functional analysis showed a significantly heightened presence of costimulatory signals (e.g., CD40/CD40L; P < 0.05). …”
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    Molecular Networks Involved in the Immune Control of BK Polyomavirus
  7. 4807
    “…For the structural and functional analysis, a 346 amino acid encoding protein sequence of haloacid dehalogenase is retrieve from NCBI data base. …”
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    Structure prediction and evolution of a halo-acid dehalogenase of Burkholderia mallei
  8. 4808
    “…The variations were absent in 400 control alleles and the altered amino acids were completely conserved evolutionarily. Functional analysis showed that the GATA5 mutants were associated with significantly decreased transcriptional activation compared with their wild-type counterpart. …”
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    GATA5 loss-of-Function Mutations Underlie Tetralogy of Fallot
  9. 4809
    “…A major advantage of these approaches is that they permit targeted gene misexpression with extremely high spatiotemporal resolution and over a large range of developmental stages, allowing functional analysis at a level, speed and ease that is difficult to achieve in other systems. …”
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    Rediscovering the chick embryo as a model to study retinal development
  10. 4810
    “…About 1400 transcripts were differentially expressed between pre- and post-RASP leukocytes. Upon functional analysis, immune response was the most enriched biological process, and most of the transcripts associated with the immune response were downregulated. …”
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    Transcriptome characterization of immune suppression from battlefield-like stress
  11. 4811
    “…Here, we provide the first functional analysis of Gbx1. We generated mice containing a conditional Gbx1 allele in which exon 2 that contains the functional homeodomain is flanked with loxP sites (Gbx1(flox)); Cre-mediated recombination of this allele results in a Gbx1 null allele. …”
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    Characterization of the Gbx1(−/−) Mouse Mutant: A Requirement for Gbx1 in Normal Locomotion and Sensorimotor Circuit Development
  12. 4812
    “…To our knowledge, this is the first report of functional analysis of somatic breast cancer mutations in FGFR2 providing evidence for the activating nature of FGFR2-mediated signalling in the pathogenesis of breast cancer.…”
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    Activating Somatic FGFR2 Mutations in Breast Cancer
  13. 4813
    “…Selective hyper-production of cellulases and hemicellulases but not all the secreted proteins was observed in the mutant, making it a more specific producer of lignocellulolytic enzymes. Functional analysis identified that changes in several transcriptional regulatory elements played crucial roles in the cellulase hyper-producing characteristics of the mutant. …”
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    Long-term strain improvements accumulate mutations in regulatory elements responsible for hyper-production of cellulolytic enzymes
  14. 4814
    por Wang, Xi, Cairns, Murray J
    Publicado 2013
    “…However, existing functional analysis methods can only account for differential expression, leaving differential splicing out altogether. …”
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    Gene set enrichment analysis of RNA-Seq data: integrating differential expression and splicing
  15. 4815
    “…This allowed us to establish a unique signature composed of highly interconnected genes characteristic of totipotency (61 genes), in vivo pluripotency (20 genes), and in vitro pluripotency (107 genes), and which are also proprietary according to functional analysis. This systems biology approach has led to an improved understanding of the molecular and signaling processes governing human pre-implantation embryo development, as well as enabling us to comprehend how hESCs might adapt to in vitro culture conditions.…”
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    Defining the Genomic Signature of Totipotency and Pluripotency during Early Human Development
  16. 4816
    “…The catalogue of secreted proteins contained proteins involved in nutrient uptake, migration, and evasion from host defenses. A comparative functional analysis of the secretome profiles among parasitic nematodes revealed a marked expansion of secreted peptidases and peptidase inhibitors in B. xylophilus via gene duplication and horizontal gene transfer from fungi and bacteria. …”
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    Secretome Analysis of the Pine Wood Nematode Bursaphelenchus xylophilus Reveals the Tangled Roots of Parasitism and Its Potential for Molecular Mimicry
  17. 4817
    “…Clustal Omega and MUSCLE), pairwise sequence alignment and protein functional analysis (e.g. InterProScan and Phobius). The REST/SOAP Web Services (http://www.ebi.ac.uk/Tools/webservices/) interfaces to these databases and tools allow their integration into other tools, applications, web sites, pipeline processes and analytical workflows. …”
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    Analysis Tool Web Services from the EMBL-EBI
  18. 4818
    “…In a concluding section, we discuss these findings in the context of broader theoretical issues related to action and event representation, arguing that a detailed functional analysis of action simulation in cognitive, neural, and computational terms may help to further advance our understanding of action cognition and motor control.…”
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    Action simulation: time course and representational mechanisms
  19. 4819
    “…This allele displays a drastic frequency difference between upland and irrigated rice, and a selective sweep is observed around this allele. Functional analysis indicates that in upland rice, this allele is associated with significantly higher abscisic acid levels and denser lateral roots, suggesting its association with upland rice suitability. …”
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    Analysis of elite variety tag SNPs reveals an important allele in upland rice
  20. 4820
    “…Dystrophin mRNA and protein was expressed in normal mice carotid bodies however, they are absent in mdx mice. Functional analysis revealed abnormalities in Dejours test and the early component of the hypercapnic ventilatory reflex in mdx mice. …”
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    Ventilatory Chemosensory Drive Is Blunted in the mdx Mouse Model of Duchenne Muscular Dystrophy (DMD)
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