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  1. 8181
    “…In our previous studies, we performed a transcriptomic and functional analysis of CRC in the early stages of metastasis induced by the overexpression of Snail, the transcription factor involved in EMT initiation. …”
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    Implications of ABCC4–Mediated cAMP Efflux for CRC Migration
  2. 8182
    “…In this study, we cloned five G6PDH genes (HvG6PDH1 to HvG6PDH5) from highland barley and characterized their encoded proteins. Functional analysis of HvG6PDHs in E. coli showed that HvG6PDH1 to HvG6PDH5 encode the functional G6PDH proteins. …”
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    Identification, Characterization, and Stress Responsiveness of Glucose-6-phosphate Dehydrogenase Genes in Highland Barley
  3. 8183
    “…CONCLUSIONS: Our findings identified two novel variants in PRPF31 in two Chinese families with adRP, expanding the mutational spectrum of this gene. Functional analysis reveals that these variants lead to the truncation of the PRPF31 protein.…”
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    Identification of two novel PRPF31 mutations in Chinese families with non‐syndromic autosomal dominant retinitis pigmentosa
  4. 8184
    por Xu, Meng, Liu, Jinxiang, Pan, Lu, Yang, Sirui
    Publicado 2020
    “…Further studies with larger sample size and functional analysis of these cells are needed.…”
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    Peripheral follicular cytotoxic T -like cells in Kawasaki disease with coronary artery aneurysms: A case report
  5. 8185
    “…CONCLUSION: This study reported the genome organization, evolutionary characteristics and expression profile of the bHLH family in barley, which not only provide the targets for further functional analysis, but also facilitate better understanding of the regulatory network bHLH genes involved in stress tolerance in barley.…”
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    Genome-wide Identification, Evolution and Expression Analysis of Basic Helix-loop-helix (bHLH) Gene Family in Barley (Hordeum vulgare L.)
  6. 8186
    “…Compared with canonical CsGA2ox8.1, the CsGA2ox8.2 isoform presented intron retention between the second and third exons. Functional analysis proved that the transcript of CsGA2ox8.1 but not CsGA2ox8.2 played a role in the deactivation of bioactive GAs. …”
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    Plant buffering against the high-light stress-induced accumulation of CsGA2ox8 transcripts via alternative splicing to finely tune gibberellin levels and maintain hypocotyl elongation
  7. 8187
    “…Here, we show that ubiquitin-specific peptidase 47 (USP47) is a potential target to overcome TKI resistance. Functional analysis shows that USP47 knockdown represses proliferation of CML cells sensitive or resistant to imatinib in vitro and in vivo. …”
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    Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia
  8. 8188
    “…The results of the multivariate analysis demonstrated that high expression levels of TET2 were a predictor of a favorable prognosis, whereas AMPK was not a significant factor for determining patient prognosis; therefore, further functional analysis of AMPK/TET2 expression in CRC is needed.…”
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    Expression of AMP-activated protein kinase/ten-eleven translocation 2 and their clinical relevance in colorectal cancer
  9. 8189
    “…Here, we identify four distinct transcriptional clusters by single-cell RNA sequencing in the mouse SAN. Functional analysis of differentially expressed genes identifies a core cell cluster enriched in the electrogenic genes. …”
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    Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing
  10. 8190
    “…Here, we use cryo-EM, MD simulation and functional analysis to elucidate the structural basis for the mismatch tolerance of DMC1. …”
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    Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures
  11. 8191
    “…Based on in silico functional analysis, integrated miRNA-mRNA datasets allowed the identification of 10 miRNA-target family modules, which might participate in the benefit. …”
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    Integrated miRNA-mRNA analysis reveals the roles of miRNAs in the replanting benefit of Achyranthes bidentata roots
  12. 8192
    “…We performed statistical and functional analysis of differentially expressed proteins to identify biomarker candidates complementing conventional serological tests. …”
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    Serum biomarker panel for the diagnosis of rheumatoid arthritis
  13. 8193
    “…Here, by integrating functional analysis and receptor binding, we identify a functional epitope that displays molecular mimicry with human erythropoietin (EPO) and promotes angiogenesis through common beta chain receptor (βCR) activation. …”
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    Evolution toward beta common chain receptor usage links the matrix proteins of HIV-1 and its ancestors to human erythropoietin
  14. 8194
    “…Mutagenesis, transfection, and functional analysis were performed on the discovered genetic abnormalities. …”
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    Autosomal Dominant Hypocalcemia With Atypical Urine Findings Accompanied by Novel CaSR Gene Mutation and VitD Deficiency
  15. 8195
    “…Among the 212 modules identified by WGCNA, the red, darkred, midnightblue and paleturquoise4 modules were chosen for subsequent analysis. Functional analysis evidenced pathways involved in extracellular matrix (ECM) organization, collagen metabolism, cellular signaling and unfolded protein response. …”
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    Weighted gene co-expression network analysis identifies molecular pathways and hub genes involved in broiler White Striping and Wooden Breast myopathies
  16. 8196
    “…Then, the test dataset and the ICGC dataset were used to evaluate our model, and the ROCs of test dataset were 0.667 and 0.777, respectively. In addition, functional analysis and correlation analysis showed that immune-related pathways were significantly enriched. …”
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    Ferroptosis-Related Gene Model to Predict Overall Survival of Ovarian Carcinoma
  17. 8197
    por Hou, Jili, Yao, Cheng
    Publicado 2021
    “…We performed a functional analysis of the collected candidate genes and explored three LUAD-related genes (VWF, PECAM1, and COL1A1) associated with the overall survival rates of patients with LUAD. …”
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    Potential Prognostic Biomarkers of Lung Adenocarcinoma Based on Bioinformatic Analysis
  18. 8198
    “…The use of RNAi technology in L. trifolii will contribute to the functional analysis of critical genes and may potentially provide a new idea for control strategies. …”
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    RNA Interference of Genes Encoding the Vacuolar-ATPase in Liriomyza trifolii
  19. 8199
    “…Microarray screening led to the discovery of a gene with high amino acid similarity to 2-isopropylmalate synthase (IPMS). However, functional analysis of recombinant protein revealed its substrate preference differed substantially from IPMS and was more typical of CMS. …”
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    Citramalate synthase yields a biosynthetic pathway for isoleucine and straight- and branched-chain ester formation in ripening apple fruit
  20. 8200
    “…Gene ontology (GO) functional analysis of the DEGs indicated that the polysaccharide metabolic process, carbohydrate metabolic process, cellular carbohydrate metabolic process, cell wall macromolecule metabolic process, and photosystem GO terms were distinctively significantly enriched in H4. …”
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    Comparative Transcriptome Analysis Provides New Insights into the Molecular Regulatory Mechanism of Adventitious Root Formation in Ramie (Boehmeria nivea L.)
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