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  1. 8521
    “…Here, we reported the isolation and functional analysis of an alfalfa SENESCENCE-ASSOCIATED GENE113 (MsSAG113), which belongs to the PP2C family and mainly plays a role in promoting plant senescence. …”
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    Overexpression of MsSAG113 gene promotes leaf senescence in alfalfa via participating in the hormone regulatory network
  2. 8522
    “…OsNAC092 mutant rice exhibited a higher ability to scavenge more ROS and maintained a high GSH/GSSG ratio and redox level under drought stress, which could protect cells from oxidant stress, revealing the importance of OsNAC092 in the rice’s response to abiotic stress. Functional analysis of OsNAC092 will be useful to explore many rice resistance genes in molecular breeding to aid in the development of modern agriculture.…”
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    Knocking Out the Transcription Factor OsNAC092 Promoted Rice Drought Tolerance
  3. 8523
    “…RESULTS: The WGCNA identifies five modules and four modules as significant modules with OB and AD, respectively. Functional analysis of shared genes emphasized that inflammation response and mitochondrial functionality were common features in the pathophysiology of OB and AD. …”
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    Exploring the common gene signatures and pathogeneses of obesity with Alzheimer’s disease via transcriptome data
  4. 8524
    “…Genome-wide association testing with functional analysis led to the identification of two genes involved in seed weight and seed length regulation. …”
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    Genomic insights into the genetic signatures of selection and seed trait loci in cultivated peanut
  5. 8525
    “…In our study, we constructed a prognostic model of CRGs in HCC and performed immune infiltration, functional analysis, immune checkpoint and drug sensitivity analysis. …”
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    Prognostic and immune correlation evaluation of a novel cuproptosis-related genes signature in hepatocellular carcinoma
  6. 8526
    por Yamagami, Ryota, Hori, Hiroyuki
    Publicado 2022
    “…Here, we adapt a tRNA-sequencing technique and design a new functional analysis where we perform mutational profiling of tRNA modifications to gain mechanistic insights into how tRNA modification enzymes recognize substrate tRNA. …”
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    Application of mutational profiling: New functional analyses reveal the tRNA recognition mechanism of tRNA m(1)A22 methyltransferase
  7. 8527
    “…Composition of oral microbial was huge different among S group, for the Actinobacteria and Veillonella were significantly increased, which showed significant dysbiosis of the oral microbiome. Functional analysis of metabolic pathways of oral microbiota demonstrated that degradation of organic acids and amino acids were significantly increased in S group. …”
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    Distinctive microbiota of delayed healing of oral mucositis after radiotherapy of nasopharyngeal carcinoma
  8. 8528
    “…The dysregulation of circulating miRNAs provides new insights into the underlying immunological mechanisms, and their possible use as biomarkers to discriminate against patients with severe COVID-19. Functional analysis showed that most enriched pathways were significantly associated with processes related to cell proliferation and immune responses (innate and adaptive). …”
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    miR-146a, miR-221, and miR-155 are Involved in Inflammatory Immune Response in Severe COVID-19 Patients
  9. 8529
    “…Proteins overexpressed in CC1 were mainly related to translation and ribosome, while proteins overexpressed in CC2 were mainly related to focal adhesion and membrane. Second, a functional analysis using probabilistic graphical models was performed. …”
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    Proteomics Characterization of Clear Cell Renal Cell Carcinoma
  10. 8530
    “…RESULTS: LC-MS/MS revealed 71 differentially expressed proteins and 18 differentially abundant metabolites. The functional analysis highlighted the importance of complement binding, coagulation, secretory granules and vesicle lumen. …”
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    Serum Proteomics Combined with Metabolomics Analysis Explore the Molecular Biological Characteristics of Eruptive Syringoma
  11. 8531
    “…Generation of recombinant FI for functional analysis has thus far been constrained by incomplete processing resulting in a preparation of active and inactive protein. …”
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    A novel method for real-time analysis of the complement C3b:FH:FI complex reveals dominant negative CFI variants in age-related macular degeneration
  12. 8532
    “…Machine learning analysis confirmed the significance of several of the modulated bacteria found by the univariate analysis. The functional analysis showed a decreased abundance of SCFA (propionate) production in BC compared to HC. …”
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    Breast cancer patients from the Midwest region of the United States have reduced levels of short-chain fatty acid-producing gut bacteria
  13. 8533
    “…An association analysis between the muscle transcriptome and its FA profile was performed, followed by a concordance and functional analysis. Overall, a list of well-known (e.g., PLIN1, LEP, ELOVL6, SC5D, NCOA2, ACSL1, MDH1, LPL, LGALS12, TFRC, GOT1, and FBP1) and novel (e.g., TRARG1, TANK, ENSSSCG00000011196, and ENSSSCG00000038429) candidate genes was identified, either in association with specific or several FA traits. …”
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    Global analysis of the association between pig muscle fatty acid composition and gene expression using RNA-Seq
  14. 8534
    “…Therefore, accurate identification of protein-protein interaction binding sites has become a key step in the functional analysis of proteins. However, since most computational methods are designed based on biological features, there are no available protein language models to directly encode amino acid sequences into distributed vector representations to model their characteristics for protein-protein binding events. …”
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    Learning the protein language of proteome-wide protein-protein binding sites via explainable ensemble deep learning
  15. 8535
    “…The Kyoto Encyclopedia of Genes and Genomes functional analysis revealed that most gut microbes played roles in membrane transport, cell replication and repair. …”
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    Transport Stress Induces Oxidative Stress and Immune Response in Juvenile Largemouth Bass (Micropterus salmoides): Analysis of Oxidative and Immunological Parameters and the Gut Microbiome
  16. 8536
    “…In this study, we identified 12 BrPEBP genes and focused our functional analysis on four BrFT-like genes by overexpressing them individually in an FT loss-of-function mutant in Arabidopsis thaliana. …”
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    Their C-termini divide Brassica rapa FT-like proteins into FD-interacting and FD-independent proteins that have different effects on the floral transition
  17. 8537
    “…BACKGROUND: to perform a functional analysis of a new NK2 homeobox 1 (NKX2-1) variant (c.85_86del denominated NKX2-1(DEL)) identified in a family presenting with isolated respiratory disease, in comparison to another frameshift variant (c.254dup denominated NKX2-1(DUP)) identified in a subject with classical brain-lung-thyroid syndrome. …”
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    Deciphering an isolated lung phenotype of NKX2-1 frameshift pathogenic variant
  18. 8538
    “…A total of 1229 differentially expressed genes (844 up- and 385 down-regulated) and 86 differentially expressed miRNAs (40 up- and 46 down-regulated) were identified after MC-LR exposure. Functional analysis indicated that DEGs is mainly involved in the oxidative activity process in molecular functional categories, and proteasome was the most enriched KEGG pathway for mRNAs profile. …”
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    Integrated analysis of mRNA and microRNA expression profiles in hepatopancreas of Litopenaeus vannamei under acute exposure to MC-LR
  19. 8539
    “…Furthermore, predicted functional analysis revealed significantly upregulated pathways relevant to the altered vaginal microbiota in CC. …”
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    Leveraging 16S rRNA data to uncover vaginal microbial signatures in women with cervical cancer
  20. 8540
    “…RESULTS: In total, 159 common DEGs–85 downregulated genes and 74 upregulated genes—were identified. Functional analysis emphasized that the immune response was a common feature to epilepsy and SAH. …”
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    Identification of hub genes significantly linked to subarachnoid hemorrhage and epilepsy via bioinformatics analysis
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