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  1. 8661
    “…In vitro and in vivo functional analysis of the IL-2rE in the rodent thymic lymphoma-derived, CD4(−)CD8(−) cell line PC60 demonstrated that three separate elements, sites I, II, and III, were necessary for IL-2 responsiveness; these three sites demonstrate functional cooperation. …”
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    Elf-1 Contributes to the Function of the Complex Interleukin (IL)-2–responsive Enhancer in the Mouse IL-2 Receptor α Gene
  2. 8662
    “…BACKGROUND: With the completion of the human genome sequence the functional analysis and characterization of the encoded proteins has become the next urging challenge in the post-genome era. …”
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    The full-ORF clone resource of the German cDNA Consortium
  3. 8663
    “…Monotonic analysis added 46% more genes. A functional analysis of the resulting 448 differentially expressed genes yielded functional changes beyond what would be expected from only the mutagenic properties of MX. …”
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    Toxicogenomic analysis incorporating operon-transcriptional coupling and toxicant concentration-expression response: analysis of MX-treated Salmonella
  4. 8664
    “…Here, we probe the role of gating charges in the IIS4 segment in β-scorpion toxin action by mutagenesis and functional analysis of the resulting mutant sodium channels. …”
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    Neutralization of Gating Charges in Domain II of the Sodium Channel α Subunit Enhances Voltage-Sensor Trapping by a β-Scorpion Toxin
  5. 8665
    “…Expression of genes is coordinated with four major patterns of expression observed: high in floral buds; high during cell division; high when starch levels and cell expansion rates peak; and high during ripening. Functional analysis associated cell cycle genes with early fruit development and three core cell cycle genes are significantly up-regulated in the early stages of fruit development. …”
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    Global gene expression analysis of apple fruit development from the floral bud to ripe fruit
  6. 8666
    “…Morphological and functional analysis showed that both the P-gp-positive and P-gp-negative clones were more differentiated than the parent cells in terms of enhanced activity of cellular alkaline phosphatase, an increase in well-organized actin stress fibres and enhanced osteogenic activity. …”
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    Osteoblastic differentiation and P-glycoprotein multidrug resistance in a murine osteosarcoma model
  7. 8667
    “…There were no differences in the frequencies of these polymorphisms between these melanoma patients and patients with familial melanoma or healthy Swedish individuals. Functional analysis of variants MGMT-I143V and -I143V/K178R was performed by in vitro mutagenesis in Escherichia coli. …”
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    O(6)-methylguanine-DNA-methyltransferase expression and gene polymorphisms in relation to chemotherapeutic response in metastatic melanoma
  8. 8668
    “…One previously uncharacterized gene, namely HBV pre-S2 trans-regulated protein 3 (HSPC111), was acutely upregulated after estrogen treatment or inducible expression of c-Myc, and was selected for further functional analysis using over-expression and knock-down strategies. …”
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    The estrogen and c-Myc target gene HSPC111 is over-expressed in breast cancer and associated with poor patient outcome
  9. 8669
    “…There were 4 excellent, 3 good, 4 fair and 2 poor bony results and 1 excellent, 3 good, 6 fair and 2 poor results. 1 patient was lost for follow up at final functional analysis. 9 patients who underwent internal bone transport had an average bone gap of 5.4 cms [1.5–9 cms] with an average duration of fixation of 8.5 months [4–11 months]. …”
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    Outcomes of Ilizarov ring fixation in recalcitrant infected tibial non-unions – a prospective study
  10. 8670
    “…The Blast2GO software was shown to represent a comprehensive bioinformatics solution for an annotation-based functional analysis. According to the whole set of GO annotations, the AFLP technology generates thorough information for angiosperm gene products and shares common features across angiosperm species and families. …”
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    Large-scale Gene Ontology analysis of plant transcriptome-derived sequences retrieved by AFLP technology
  11. 8671
    “…Hence, we first validated the limits of the WOX13 orthologous group (WOX13 OG) using the occurrence of other clade specific signatures and conserved intron insertion sites. Secondly, a functional analysis using expression data and mutants was undertaken. …”
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    Genes of the most conserved WOX clade in plants affect root and flower development in Arabidopsis
  12. 8672
    “…Significantly, despite these changes RNA splice defects were not observed and functional analysis revealed only subtle cardiac dysfunction, characterized by conduction defects that primarily manifest under anesthesia. …”
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    Cytoplasmic CUG RNA Foci Are Insufficient to Elicit Key DM1 Features
  13. 8673
    “…We performed follow-up genetic, biostatistical, and functional analysis of NPY in early-onset CAD. In familial CAD (GENECARD, N = 420 families), we found increased microsatellite linkage to chromosome 7p14 (OSA LOD = 4.2, p = 0.004) in 97 earliest age-of-onset families. …”
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    Neuropeptide Y Gene Polymorphisms Confer Risk of Early-Onset Atherosclerosis
  14. 8674
    “…We observed a total of 81 trans-eQTL clusters (hot-spots), defined as consisting of ≥10 eQTLs linked to a common region, with very high levels of correlation between trans-regulated transcripts (77.2–90.2%). Moreover, functional analysis of large trans-eQTL clusters (≥30 eQTLs) revealed significant functional enrichment among genes comprising 80% of the large clusters. …”
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    Genome-Wide Co-Expression Analysis in Multiple Tissues
  15. 8675
    “…Decrease of Fas at the plasma membrane seems to be caused by MMP7 since its inhibition restores Fas levels. Moreover, functional analysis of Fas demonstrates that this receptor was less potent in inducing apoptosis in RHT29 cells and that its activation induces MAPK signaling in resistant cells. …”
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    The Role of MMP7 and Its Cross-Talk with the FAS/FASL System during the Acquisition of Chemoresistance to Oxaliplatin
  16. 8676
    “…Furthermore, the number of candidate genes for penicillin transporters was strongly reduced, thus enabling a focusing of functional analysis studies. CONCLUSION: This study demonstrates the usefulness of combinatorial transcriptome analysis in chemostat cultures to dissect effects of biological and process parameters on gene expression regulation. …”
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    Exploring and dissecting genome-wide gene expression responses of Penicillium chrysogenum to phenylacetic acid consumption and penicillinG production
  17. 8677
    “…These properties of the UL31 protein provide a prerequisite for further functional analysis of this gene.…”
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    Expression and characterization of the UL31 protein from duck enteritis virus
  18. 8678
    “…BACKGROUND: Budded baculoviruses are utilized for vaccine, the production of antibody and functional analysis of transmembrane proteins. In this study, we tried to produce and purify the recombinant Bombyx mori nucleopolyhedrovirus (rBmNPV-hPRR) that displayed human (pro)renin receptor (hPRR) connected with FLAG peptide sequence on its own surface. …”
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    High-titer preparation of Bombyx mori nucleopolyhedrovirus (BmNPV) displaying recombinant protein in silkworm larvae by size exclusion chromatography and its characterization
  19. 8679
    “…The models provide a structural framework for interpretation of the resulting functional analysis.…”
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    Structural Models of Human eEF1A1 and eEF1A2 Reveal Two Distinct Surface Clusters of Sequence Variation and Potential Differences in Phosphorylation
  20. 8680
    “…Furthermore, we analyse the effect of differences in updated annotation on functional analysis for an experiment involving Eimeria infected chickens and finally we propose guidelines for optimal annotation strategies. …”
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    Comparison of three microarray probe annotation pipelines: differences in strategies and their effect on downstream analysis
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