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  1. 8901
    “…Global microarray analysis revealed profound changes in the transcriptome of polarized canine macrophages. Functional analysis pointed out that M1-polarization was associated with biological processes such as “respiratory burst”, whereas M2-polarization was associated with processes such as “mitosis”. …”
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    Morphologic, phenotypic, and transcriptomic characterization of classically and alternatively activated canine blood-derived macrophages in vitro
  2. 8902
    “…RESULTS: In the discovery stage, for gestational length, four loci (EBF1, EEFSEC, AGTR2 and WNT4) achieved genomewide significance, all of which were replicated in the Nordic data sets. Functional analysis of the WNT4 locus indicated the likely causative variant alters the binding of ESR1. …”
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    Genetic Associations with Gestational Length and Spontaneous Preterm Birth
  3. 8903
    “…RESULTS: Microarray analysis revealed that 36 miRNAs were differentially expressed between the curcumin‐treated and control groups. miR‐330‐5p exhibited maximum upregulation, while miR‐25‐5p exhibited maximum downregulation in the curcumin treatment group. mRNA expression profiles and functional analysis indicated that 226 differentially expressed mRNAs belonged to different functional categories. …”
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    Integrated microRNA and gene expression profiling reveals the crucial miRNAs in curcumin anti‐lung cancer cell invasion
  4. 8904
    “…CONCLUSIONS: This is the first functional analysis of a secondary metabolite gene cluster in the ergot fungus besides that for the classical ergot alkaloids. …”
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    Identification and characterization of the ergochrome gene cluster in the plant pathogenic fungus Claviceps purpurea
  5. 8905
    “…Recently, rare variants such as copy-number variants and single-nucleotide variants have been a focus of research because of their large effect size associated with increased susceptibility to SCZ and ASD and the possibility of elucidating the pathophysiology of mental disorder through functional analysis of the discovered rare variants. To discover rare variants with large effect size and to evaluate their role in the etiopathophysiology of SCZ and ASD, we sequenced the RTN4R coding exons with a sample comprising 370 SCZ and 192 ASD patients, and association analysis using a large number of unrelated individuals (1716 SCZ, 382 ASD and 4009 controls). …”
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    A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility
  6. 8906
    “…A 3D structural model indicated that Ala55Thr could destabilize the conformation of the CX3CR1 helix 8 and affect its interaction with a heterotrimeric G protein. In vitro functional analysis showed that the CX3CR1-Ala55Thr mutation inhibited cell signaling induced by fractalkine, the ligand for CX3CR1. …”
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    Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders
  7. 8907
    “…The fine mapping and candidate gene analysis of qNUE6 provide the basis of molecular breeding for genetic improvement of rice varieties with high NUE, and lay the foundation for further cloning and functional analysis.…”
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    QTL Mapping by Whole Genome Re-sequencing and Analysis of Candidate Genes for Nitrogen Use Efficiency in Rice
  8. 8908
    “…As FHRs are highly similar among themselves and toward FH, obtaining specific reagents for quantification of serum levels and functional analysis is challenging. In this study, we generated antibodies and developed ELISAs to measure FHR-1, FHR-2, and FHR-5 in serum. …”
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    Factor H-Related (FHR)-1 and FHR-2 Form Homo- and Heterodimers, while FHR-5 Circulates Only As Homodimer in Human Plasma
  9. 8909
    “…To further investigate the involvement of these miRNAs in tolerance to abiotic stresses, sugarcane miR156 was selected for functional analysis. RT-qPCR revealed that miR156 levels increased in sugarcane during cold, salt and drought stress treatments. …”
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    miRNA alteration is an important mechanism in sugarcane response to low-temperature environment
  10. 8910
    “…We modelled 6,497 daily PA profiles from singleton children (3,176 boys; mean age: 7.5 years) by means of splines, and used functional analysis of variance to examine the cross-sectional relation of time and place of measurement, demographic and behavioural characteristics to smoothed PA profiles. …”
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    Using functional data analysis to understand daily activity levels and patterns in primary school-aged children: Cross-sectional analysis of a UK-wide study
  11. 8911
    “…We suggest the use of the baculovirus system for high-level expression of Snakin/GASA peptides, for biological assays, structural and functional analysis and antibody production, as an important step to both elucidate their accurate physiological role and to deepen the study of their biotechnological uses. …”
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    Successful production of the potato antimicrobial peptide Snakin-1 in baculovirus-infected insect cells and development of specific antibodies
  12. 8912
    “…Thus, these bacteria should be further identified and subjected to functional analysis to improve the utilization of crop residues in ruminants.…”
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    Progressive Colonization of Bacteria and Degradation of Rice Straw in the Rumen by Illumina Sequencing
  13. 8913
    “…The present study identified increased expression levels of Wnt10a in two cell lines, SKOV3 and A2780, using reverse transcription-polymerase chain reaction. Functional analysis indicated that the viability rate and migratory ability of SKOV3 cells was significantly inhibited following Wnt10a knockdown using short interfering RNA (siRNA) technology. …”
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    Clinical significance and biological role of Wnt10a in ovarian cancer
  14. 8914
    “…Then validation with quantitative real-time PCR was performed and the result was in accordance with the array data. Functional analysis of these differentially expressed miRNAs with Ingenuity Pathway Analysis (IPA) revealed a common signaling network including MYC, CCND1, IGF1 and RELA. …”
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    Plasma microRNA alterations between EGFR-activating mutational NSCLC patients with and without primary resistance to TKI
  15. 8915
    “…Some of our diagnosed cases illustrated that successful molecular investigation may allow a better treatment strategy and avoid unnecessary and even invasive investigations. Functional analysis could be performed to further study the pathogenicity of the VUS identified in DNM1 and TUBA8.…”
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    Gene panel analysis for nonsyndromic cryptogenic neonatal/infantile epileptic encephalopathy
  16. 8916
    “…While its role is well-characterized in some heterotrophic bacteria, we subjected a cyanobacterial homolog to functional analysis, thereby extending the scope of 6S RNA action to the special challenges of photoautotrophic lifestyles. …”
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    6S RNA plays a role in recovery from nitrogen depletion in Synechocystis sp. PCC 6803
  17. 8917
    “…Such maps provide important starting points for neuron classification, for functional analysis, and for developmental studies aimed at defining the molecular mechanisms of neuron identity acquisition and neuron identity diversification. …”
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    An atlas of Caenorhabditis elegans chemoreceptor expression
  18. 8918
    “…Furthermore, the LFES is an independent prognostic predictor of survival and demonstrates superior prognostic performance compared with the clinical covariates for predicting 5-year survival (AUC = 0.887). Functional analysis has linked the expression of prognostic lncRNAs to well-known tumor suppressor or ontogenetic pathways in endometrial carcinogenesis. …”
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    A novel lncRNA-focus expression signature for survival prediction in endometrial carcinoma
  19. 8919
    “…The phenotype profiles, functionality, and genome stability of all hiPSC-derived ECs were assessed and compared with HUVECs and HSVECs. hiPSC-derived ECs resembled their natural EC counterparts, as shown by the expression of the endothelial surface markers CD31 and CD144 and the results of the functional analysis. Higher expression of endothelial progenitor markers CD34 and kinase insert domain receptor (KDR) was measured in hiPSC-derived ECs. …”
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    Reprogramming of Adult Peripheral Blood Cells into Human Induced Pluripotent Stem Cells as a Safe and Accessible Source of Endothelial Cells
  20. 8920
    “…By combining phenotypic analysis of exhaustion markers with functional analysis of cytokine production, we found that PD-1(+) CD4(+) cells in cancer hosts failed to make any cytokines following CLP, while the 2B4(+) PD-1(lo) cells in cancer mice secreted increased TNF during sepsis. …”
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    Pre-existing malignancy results in increased prevalence of distinct populations of CD4(+) T cells during sepsis
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