“…The mechanism of retinal ganglion cell (RGC) death was hypothesized on the basis of DEP functional analysis. A total of 20 DEPs were validated by using PRM, and prostaglandin-H2 D-isomerase was found to have the potential to evaluate optic nerve damage. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Combined with receiver operating characteristic and regression analyses, we determined PRSS35 as a novel TME‐based prognostic biomarker in SKCM, and functional analysis enriched immune‐related cells, functions and signalling pathways. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To assess ancestry-specific adaptive signals, a selective sweep scan in an AMR reference population from 1KGP together with an in silico functional analysis highlighted the Tripartite Motif family and the human leukocyte antigen genes, with crucial role in the immune response against pathogens. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The risk score was found to be an independent predictor of OS using multivariate Cox analysis. The functional analysis illustrated that the immune status and cancer-related pathways for the two-risk cohorts were clearly different. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The ATG signature, stratifying patients into high and low autophagy risk groups, was validated in the validation (HR, 2.29[1.15–4.55]; p = 1.5 × 10–2) and meta-validation cohorts (HR, 2.5[1.03–6.06]; p = 3.63 × 10–2) and proved to be prognostic in a multivariate analysis. Functional analysis revealed enrichment of several immune/inflammatory pathways in the high autophagy risk group, where increased infiltration of T regulatory cells (Tregs) and decreased infiltration of M1 macrophages were observed. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This work further illustrates the limitations of the prediction models and highlights the importance of conducting functional analysis of genetic variants particularly in a complex clinicopathologic scenario such as kidney transplantation.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Val18Gly) DSPP variant was shown to present with rare hypoplastic enamel defects. Functional analysis revealed that this novel variant disturbs dentinal characteristics and pulp cell behavior.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Overall, our results provide fundamental information for future functional analysis to understand the precise molecular mechanisms of the DREB gene family in S. tuberosum.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Heat inactivation at 95°C for 90 min yielded the most quantifiable proteins, and a functional analysis revealed proteins located in the ribosomal subunit. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Blood was sampled between days 1 and 21 after admission for targeted plasma biomarker analysis, cellular phenotyping, and leukocyte functional analysis via enzyme-linked immunospot assay. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Two groups were fed with a control diet (18% protein): Control (C) and Walker 256 tumour-bearing (W), and two other groups were fed with a leucine-rich diet (18% protein + 3% leucine): Leucine Control (L) and Leucine Walker 256 tumour-bearing (LW). A functional analysis (walking, behaviour, and strength tests) was performed before and after tumour inoculation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…GmHSP17.9 was also found to act as a chaperone for its interacting partner, GmNOD100, a sucrose synthase in soybean nodules which was also preferentially expressed in the infected zone of nodules, similar to GmHSP17.9. Functional analysis of GmNOD100 in composite transgenic plants revealed that GmNOD100 played an essential role in soybean nodulation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The purpose of this study was to compare host and viral gene expression differences and perform functional analysis in acutely infected, dead and cohabiting asymptomatic pigs infected with ASFV by using RNA-Seq technique; healthy pigs were used as controls. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The present study gives an in-depth understanding of K(+) transport system genes in V. radiata and will serve as a basis for a functional analysis of these genes.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Moreover, the magnitude of the transcriptomic modifications depended on the exposure duration. A functional analysis showed that genes involved in immunity and ribosomal functions were significantly affected in the gills. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Together, comparative genomics and predictive functional analysis, combined with data of the functionally characterized key proteins of the gene clusters encoding CGTases, revealed the CM-CD pathway in Thermoanaerobacterales and showed that it is involved in the synthesis, transportation, degradation, and metabolic assimilation of CDs.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Moreover, a circRNA‐microRNA‐mRNA interaction network was developed based on differentially expressed circRNAs. Functional analysis showed that pathways involved in the regulation of autophagy, PI3K‐Akt signaling, FoxO signaling, and MAPK signaling were associated with the differentially expressed circRNAs in PMOP patients. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…For TCGA and ICGC databases of univariate Cox regression analyses, the risk score was used as an independent predictor of OS (HR > 1, P < 0.001). Functional analysis showed that the relevant immune pathways and immune responses were enriched, cellular component analysis showed that the immunoglobulin complex and other related substances were enriched, and immune status existed a difference in the high- and low-risk groups. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Proteins such as PTPRC, SERPINC1, sCD44, sCD14, ANPEP, SPP1, FCGR1A, C9, sCD19, and sCD34, among others, and their functional analysis, reveals that most of them are linked to the pathology and are not detected on normal CSF. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…D(137)N substitution was observed in the keratinase KerS gene of the mutant strain S13 (KerS13uv+ems), and also seven substitution variations in KerS26 and KerS26uv of strain S26 and its mutant S26uv. Functional analysis revealed that the subtilisin-like serine protease domain containing the Asp/His/Ser catalytic triad of KerS gene was not affected by the predicted substitutions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso