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  1. 9421
    “…Through a gene expression microarray-based approach followed by GSE functional analysis the expression profile of 46 primary untreated ACC samples and of ACC (h-TERT) tumor cells was analyzed. …”
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    Functional profiles of curatively treated adenoid cystic carcinoma unveil prognostic features and potentially targetable pathways
  2. 9422
    “…Our results provide the first functional analysis by knock-out for the two GSL biosynthesis genes in winter rapeseed. …”
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    Reduced glucosinolate content in oilseed rape (Brassica napus L.) by random mutagenesis of BnMYB28 and BnCYP79F1 genes
  3. 9423
    “…Single-cell and bulk RNAseq data sets were used for functional analysis and validation of prognostic and predictive associations. …”
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    An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers
  4. 9424
    “…Cox regression and Lasso regression analyses were conducted to screen prognostic signature and to develop a risk model. RESULTS: Functional analysis showed that immune-related hub genes were involved in the migration, activation, response, and cytokine-cytokine receptor interaction of immune cells. …”
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    A new immune signature for survival prediction and immune checkpoint molecules in non-small cell lung cancer
  5. 9425
    “…Genome‐wide association studies (GWAS) have validated a strong association of atherosclerosis with the CDKN2A/B locus, a locus harboring three tumor suppressor genes: p14 ( ARF ), p15 ( INK4b ), and p16 ( INK4a ). Post‐GWAS functional analysis reveals that CUX is a transcriptional activator of p16(INK4a) via its specific binding to a functional SNP (fSNP) rs1537371 on the atherosclerosis‐associated CDKN2A/B locus, regulating endothelial senescence. …”
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    SATB2, coordinated with CUX1, regulates IL‐1β‐induced senescence‐like phenotype in endothelial cells by fine‐tuning the atherosclerosis‐associated p16(INK4a) expression
  6. 9426
    “…Verticillium dahliae Kleb is a typical soilborne pathogen that can cause vascular wilt disease on more than 400 plants. Functional analysis of genes related to the growth and virulence is crucial to revealing the molecular mechanism of the pathogenicity of V. dahliae. …”
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    VdGAL4 Modulates Microsclerotium Formation, Conidial Morphology, and Germination To Promote Virulence in Verticillium dahliae
  7. 9427
    “…According to 16S rRNA sequencing, Clostridium_sensu_stricto_1, Terrisporobacter, and Lachnospiraceae, which are important in SCFA production, were biomarkers of mulberry silage. PICRUSt functional analysis of intestinal microbes indicated that galactose metabolism, starch and sucrose metabolism, and carbohydrate digestion and absorption decreased significantly in silage treatments but increased in the control. …”
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    Effects of Silage Diet on Meat Quality through Shaping Gut Microbiota in Finishing Pigs
  8. 9428
    “…RESULTS: In this research, we identified 24 candidate immune-related DEGs via combined DEGs and functional analysis. We also found that the ratio of M0 macrophages and resting mast cells was higher in infertile group (P<0.05), whereas the amounts of activated natural killer (NK) cells was significantly lower compared with the control group (P<0.05). …”
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    Comprehensive analysis of immune-related genes associated with the microenvironment of patients with unexplained infertility
  9. 9429
    “…The area under the curve (AUC) value of the ROC curve of the predictive model is 0.763 in the training cohort GSE72970, 0.659 in the stage III/IV colorectal cancer (CRC) patients from The Cancer Genome Atlas (TCGA) data portal, and 0.639 in another validation cohort GSE39582, respectively. GSEA functional analysis revealed that the most significantly enriched pathways focused on nucleotide excision repair, base excision repair, homologous recombination, cytokine receptor interaction, chemokine signal pathway, cell adhesion molecules cams, ECM-receptor interaction, and focal adhesion. …”
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    Construction of a DDR-related signature for predicting of prognosis in metastatic colorectal carcinoma
  10. 9430
    “…Furthermore, an in-depth functional analysis, along with a comparative genomic analysis, was performed in order to correlate the taxonomic information with the organoleptic properties of the final product. …”
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    Multifactorial Microvariability of the Italian Raw Milk Cheese Microbiota and Implication for Current Regulatory Scheme
  11. 9431
    “…A total of 85 alkaloids in Gelsemium associated with 214 excitotoxicity-related targets were predicted by network pharmacology. Functional analysis showed that the toxicity of Gelsemium was mainly related to the protein phosphorylation reaction and plasma membrane function. …”
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    Network Pharmacology and Experimental Verification to Unveil the Mechanism of N-Methyl-D-Aspartic Acid Rescue Humantenirine-Induced Excitotoxicity
  12. 9432
    “…Considering the critical role of lncRNAs in cancer biology, further functional analysis of MCM3AP-AS1 in PTC may provide novel insights into PTC management. …”
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    LncRNA MCM3AP-AS1 serves as a competing endogenous RNA of miR-218 to upregulate GLUT1 in papillary thyroid carcinoma
  13. 9433
    por Zorich, Vladimir A
    Publicado 2016
    “…It shows how analysis interacts with other modern fields of mathematics such as algebra, differential geometry, differential equations, complex analysis, and functional analysis. This book provides a firm foundation for advanced work in any of these directions. …”
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    Mathematical analysis II
  14. 9434
    “…RESULTS: The subsequent analyses included 339 common DEGs, and the importance of immunity, hormone, cytokines, neurotransmitters, and insulin in these diseases was underscored by functional analysis. In addition, serotonergic synapse, ovarian steroidogenesis, estrogen signaling pathway, and regulation of lipolysis are closely related to both. …”
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    Exploring the common pathogenesis of Alzheimer’s disease and type 2 diabetes mellitus via microarray data analysis
  15. 9435
    por Ling, Ya, Li, Jindong, Zhou, Lijuan
    Publicado 2023
    “…The Gene Set Enrichment Analysis (GSEA) was used for functional analysis. The “oncoPredict” package was applied for drug sensitivity analysis. …”
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    Smoking-related epigenetic modifications are associated with the prognosis and chemotherapeutics of patients with bladder cancer
  16. 9436
    “…Latexin (LXN), an endogenous carboxypeptidase inhibitor, resulted the most-upregulated protein at T120, and this result was confirmed by ELISA. In addition, functional analysis revealed that the most strongly upregulated proteins were involved in the oxidative phosphorylation system and ATP synthesis, whereas the downregulated proteins represented the complement system and coagulation cascade. …”
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    Proteomics reveals specific biological changes induced by the normothermic machine perfusion of donor kidneys with a significant up-regulation of Latexin
  17. 9437
    “…Furthermore, the structure, along with our functional analysis, reveals how the compact TnpB recognizes the ωRNA and cleaves target DNA complementary to the guide. …”
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    Cryo-EM structure of the transposon-associated TnpB enzyme
  18. 9438
    “…Our approach is designed to facilitate in silico validation of associations beyond traditional candidate gene and literature-search approaches and to facilitate the identification of putative variants for functional analysis and reduce the incidence of false-positive candidates in current functional validation methods. …”
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    Functional genomic effects of indels using Bayesian genome-phenome wide association studies in sorghum
  19. 9439
    “…In the protein functional analysis, the significantly expressed proteins were involved in the immune response. …”
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    Proteomic profiling of protein expression changes after 3 months-exercise in ESRD patients on hemodialysis
  20. 9440
    “…We identified arginine as a key amino acid in the modulation of the C:N ratios of core genes for bacteria, archaea, and viruses. Functional analysis reveals that particle-associated bacterial metagenomes are enriched for genes that are involved in arginine metabolism and organic nitrogen compound catabolism. …”
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    Microbial and Viral Genome and Proteome Nitrogen Demand Varies across Multiple Spatial Scales within a Marine Oxygen Minimum Zone
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