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  1. 9481
    “…Finally, we performed functional analysis to elucidate the molecular mechanisms underlying diabetic skin ulcers. …”
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    XB130 inhibits healing of diabetic skin ulcers through the PI3K/Akt signalling pathway
  2. 9482
    “…Univariable and multivariable Cox regression analyses revealed that these signature genes are independent predictors of OS. Functional analysis revealed differential immune status between the two risk groups. …”
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    Development and Validation of a Novel Prognosis Model Based on a Panel of Three Immunogenic Cell Death-Related Genes for Non-Cirrhotic Hepatocellular Carcinoma
  3. 9483
    “…The two frameshift variants have been described in patients with Birt-Hogg-Dubé (BHD) syndrome while the pathogenicity of the missense variant c.124G>C (p.G42R) has not been definitively established. Functional analysis of the missense variant showed a potential impact on post-translational modification. …”
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    SAT179 Germline And Somatic Inactivating FLCN Variants In Parathyroid Cancer and Atypical Parathyroid Tumors
  4. 9484
    “…In addition, biomarkers of HCC were identified, and a prognostic model was developed. Using functional analysis and tumor microenvironment analysis, new insights were obtained into HCC. …”
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    Development and Validation of a Propionate Metabolism-Related Gene Signature for Prognostic Prediction of Hepatocellular Carcinoma
  5. 9485
    “…Our single-cell RNA sequencing analysis of hub genes across diverse immune cell types furnished insights into disease pathogenesis. Functional analysis underscored the interconnection between sepsis/sepsis-ARDS and COVID-19, enabling us to pinpoint potential therapeutic targets, transcription factor-gene interactions, DEG-microRNA co-regulatory networks, and prospective drug and chemical compound interactions involving hub genes. …”
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    A hub gene signature as a therapeutic target and biomarker for sepsis and geriatric sepsis-induced ARDS concomitant with COVID-19 infection
  6. 9486
    “…Using wildtype and IDE-KO primary microglial cultures, we performed a functional analysis at the cellular level. IDE absence alters microglial responses to environmental signals, resulting in impaired modulation of phenotypic states, with only transitory effects on amyloid-β management. …”
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    Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer’s disease and brain aging
  7. 9487
    “…Furthermore, protein–protein interaction analysis showed that hub genes were implicated in neuropeptide signaling pathways. Functional analysis of DE ncRNA-targeting genes was mostly enriched with nociception-related signaling pathways underpinning TNP. …”
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    Transcriptome-wide analysis of trigeminal ganglion and subnucleus caudalis in a mouse model of chronic constriction injury-induced trigeminal neuralgia
  8. 9488
    “…Dietary FBN significantly increased the abundance of the probiotic bacterium Roseburia inulinivorans (p < 0.05). Functional analysis of the cecal microbiota showed that ABC transporter levels and glycolysis/gluconeogenesis-associated functions were diminished in FBN-fed pigs. …”
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    Metagenomic characterization of the cecal microbiota community and functions in finishing pigs fed fermented Boehmeria nivea
  9. 9489
    “…Gene cloning and physiological and biochemical experiments reveal that sts is a novel mutant allele of Mitogen-activated protein Kinase Kinase 4 (OsMKK4), which controls the grain size, and has recently been found to be related to salt tolerance in rice. Functional analysis showed that OsSTS is constitutively expressed throughout the tissue, and its proteins are localized to the nucleus, cell membrane, and cytoplasm. …”
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    OsSTS, a Novel Allele of Mitogen-Activated Protein Kinase Kinase 4 (OsMKK4), Controls Grain Size and Salt Tolerance in Rice
  10. 9490
    “…Following this, based on the complete genome sequence od B. velezensis VJH504, specific functional analysis, Carbohydrate-Active Enzymes (CAZymes) analysis, and secondary metabolite analysis were carried out, predicting organism’s abilities for biofilm formation, production of antifungal CAZymes, and synthesis of antagonistic secondary metabolites against pathogens. …”
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    Genome sequencing and analysis of Bacillus velezensis VJH504 reveal biocontrol mechanism against cucumber Fusarium wilt
  11. 9491
    “…Moreover, 131 additional functional pathways distributed across more and even uniquely identified taxa were profiled as revealed by a peptide-centric taxonomic-functional analysis. We tested our workflow on a validated preclinical mouse model of neuropathic pain to assess longitudinal changes in host-gut microbiome interactions associated with pain - an unexplored topic for metaproteomics. …”
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    Increasing taxonomic and functional characterization of host-microbiome interactions by DIA-PASEF metaproteomics
  12. 9492
    “…Immunofluorescent staining and ex vivo functional analysis of sinus EpCs were used to validate our findings. …”
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    Increased epithelial mTORC1 activity in chronic rhinosinusitis with nasal polyps
  13. 9493
    “…Additionally, CRRS possessed distinctly superior accuracy than traditional clinical variables and molecular features. Functional analysis indicated that the differentially high expressed genes in the low‐risk group significantly enriched in T cell and B cell receptor signaling pathways. …”
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    Identification of a coagulation‐related signature correlated with immune infiltration and their prognostic implications in lung adenocarcinoma
  14. 9494
    “…Understanding these changes by functional analysis of such genes may lead to a better understanding of the infective process, thus providing new targets and strategies to control PCM.…”
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    Cell organisation, sulphur metabolism and ion transport-related genes are differentially expressed in Paracoccidioides brasiliensis mycelium and yeast cells
  15. 9495
    “…The fact that both genes overlap at their 5' ends suggests interdependencies in their regulation and may have important implications for the functional analysis of the disease gene ABCA3. Moreover, this is the first demonstration of the expression of a pseudogene and its parent gene from a common overlapping DNA region in the human genome.…”
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    The human ortholog of the rodent testis-specific ABC transporter Abca17 is a ubiquitously expressed pseudogene (ABCA17P) and shares a common 5' end with ABCA3
  16. 9496
    “…We have carried out a functional analysis, measuring repair capability in uvrA, uvrB and uvrC deletion mutants. …”
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    The uvrA, uvrB and uvrC genes are required for repair of ultraviolet light induced DNA photoproducts in Halobacterium sp. NRC-1
  17. 9497
    “…CONCLUSION: Our findings show that Hsf and Hsp family member genes represent an interaction point between multiple stress response pathways, and therefore warrant functional analysis under conditions apart from heat shock treatment. …”
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    Transcriptional profiling of Arabidopsis heat shock proteins and transcription factors reveals extensive overlap between heat and non-heat stress response pathways
  18. 9498
    “…Further specific functional analysis will provide insights into the exact role of these transcripts in oocyte competence and early embryonic development.…”
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    Alterations in transcript abundance of bovine oocytes recovered at growth and dominance phases of the first follicular wave
  19. 9499
    “…As an inroad to understanding this complexity we initiated a structural and functional analysis of the globin family in C. elegans. …”
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    Wide diversity in structure and expression profiles among members of the Caenorhabditis elegans globin protein family
  20. 9500
    “…Scatter data was analyzed both for whole lenses and regionally, to facilitate correlation with morphometric data. After functional analysis, lenses were fixed and processed for scanning electron microcopy (SEM; right eyes) and light microscopy (LM; left eyes). …”
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    Age-related compaction of lens fibers affects the structure and optical properties of rabbit lenses
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