“…Our findings provide valuable insights into the genetic basis of meat quality traits and greatly expand the number of candidate genes that may be valuable for future functional analysis and genetic improvement of meat quality.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Blood loss, hemoglobin levels, occurrence of any adverse events,functional analysis, quality of life, and pain assessmentswere compared among the three groups. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…After initial prioritization, we performed an in-depth interrogation of all noncoding and structural variants in genes when one candidate variant was detected. In addition, functional analysis of putative splice-altering variants was performed using in vitro splice assays. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In order to reveal the potential microbial mechanisms involved in OBD, we performed a functional analysis using the Geochip5 advanced microarray technology. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In a validation cohort, it was confirmed that hsa-miR-204-5p, hsa-miR-1269a, and hsa-miR-941 were downregulation, while hsa-miR-4286, hsa-miR-31-5p and hsa-miR-125b-5p were upregulation in IVF-ET placentas. Functional analysis suggested that these differentially expressed genes were significantly enriched in angiogenesis, pregnancy, PI3K-Akt and Ras signaling pathways. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We predicted 3373 lncRNAs to be regulating their target genes in cis regulating manner and 80 unique lncRNAs were observed as interacting with 136 different miRNAs, as eTMs (endogenous target mimic) targets of miRNAs and implicated them in the regulatory network of salt stress response. Functional analysis of these lncRNA revealed their association in targeting salt stress response-related genes like potassium transporter, transporter family genes, serine/threonine-protein kinase, aquaporins like TIP1-2, PIP2-5 and transcription factors like, AP2, NAC, bZIP, ERF, MYB and WRKY. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Venn diagram software was applied to screen differentially expressed genes, and gene ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The nomogram was constructed and the calibration curves demonstrated the reliability of this model. Functional analysis of risk score-associated DEmRNAs indicated that immune-related pathways and functions were significantly enriched. ssGSEA revealed that 14 immune cells and 11 immune functions were significantly dysregulated. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We identified 125 differentially expressed membrane proteins, and functional analysis indicated structural molecule activity and protein export as key biological functions of the two omics studies. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: The NEL included microglia progenitors that proliferate and ramify over time with neuroepithelial cells as feeder. In functional analysis, NEL-MG exhibited microglial functions, such as phagocytosis (microbeads, amyloid β, synaptosome), migration, and inflammatory response following lipopolysaccharide (LPS) stimulation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Background: Congenital nephrogenic diabetes insipidus (CNDI) is a rare inherited disease that is caused by mutations in arginine vasopressin receptor 2 (AVPR2) or aquaporin 2 (AQP2). Functional analysis of the mutated receptor is necessary to verify the impact of the mutation on receptor function and suggest some possible therapeutic strategies for specific functional defects. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our findings provide some insights into the molecular mechanisms of IB formation, as well as clues for further functional analysis of the identified genes to better understand the development of IBs.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Deeper structural and functional analysis will be helpful to enrich the regulatory network of cardiac remodeling and to identify potential therapeutic targets.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…As result, we identified three upregulated miRNAs (mmu‐miR‐1936, mmu‐miR‐338‐5p, and mmu‐miR‐673‐3p) significantly associated with myopia in the two microarray data sets (p < 0.05 and |Log (Fold Change) |>1). GO functional analysis suggested these three miRNAs were targeted in genes mostly enriched in morphogenesis and developmental growth of retinal tissues. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The results of functional analysis, including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Set Enrichment Analysis (GSEA), indicate that ZCCHC17 is mainly involved in immune regulation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…As a result, 200 mRNAs, 358 lncRNAs, and 4 miRNAs were differentially expressed between the two groups. Functional analysis of these differential mRNAs indicated dysregulated inflammatory response to be the primary pathological change. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the present study, a mouse model of AKI induced by cisplatin and ischemia-reperfusion (IR) was established and genome-wide profiling analysis and identification of differentially expressed genes (DEGs) in kidney tissue was conducted by Gene Ontology (GO) functional analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, protein-protein interaction (PPI) network analysis and RT-qPCR. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mechanistically, pathway enrichment and functional analysis demonstrated that BGN was positively correlated with immune and stromal scores in the TME and primarily involved in the regulation of immune response. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: We obtained 650 AD-associated genes, 447 MDD-associated genes, and 77 shared genes between AD and MDD. The functional analysis revealed that biological processes involved in cognition, neural development, synaptic transmission, and immune-related processes were enriched in the common genes, indicating a complex mechanism underlying the comorbidity of the two diseases. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These expression results of DDPs are primary functional analysis and present basic information for other economically important crops.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso