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  1. 10241
    “…METHODS: We downloaded the GEO dataset to perform a functional analysis of SMAD family activity and TGF-ß receptor protein expression in the monocyte expression profiles of patients with familial hyperlipidaemia (FH). …”
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    Negative correlation between endoglin levels and coronary atherosclerosis
  2. 10242
    por Liu, Jing, Zhu, Xingwu, Yan, Meinan, Li, Hui
    Publicado 2021
    “…We also performed circRNA-miRNA-mRNA network prediction and functional analysis for hsa_circ_0005092 and hsa_circ_0002647. …”
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    Development of a two-circular RNA panel as potential prognostic biomarker for gastric cancer
  3. 10243
    “…RNA was isolated from PBMCs and single-end 75 bp RNA sequencing was performed using Illumina NextSeq 550 instrument followed by gene-level differential expression analysis. Functional analysis was carried out on information related to the role of genes, such as signaling pathways and biological processes. …”
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    Identification of disease- and headache-specific mediators and pathways in migraine using blood transcriptomic and metabolomic analysis
  4. 10244
    “…We investigated the regulation pattern of miRNAs-mRNAs and observed a total of 12 miRNA-mRNA pairs involved in negative regulation. Functional analysis concentrated on insulin resistance, the T cell receptor signaling pathway, and other inflammation-related pathways. …”
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    Aberrant miRNA-mRNA regulatory network in polycystic ovary syndrome is associated with markers of insulin sensitivity and inflammation
  5. 10245
    “…KEY MESSAGE: Identification and functional analysis of the male sterile gene MS6 in Glycine max. …”
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    A single nucleotide polymorphism in an R2R3 MYB transcription factor gene triggers the male sterility in soybean ms6 (Ames1)
  6. 10246
    “…The changes in the phosphoproteome affected a diverse range of cellular processes and functional analysis suggested that this response induced an immediate reactive state and prepared cells for subsequent transcriptional responses. …”
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    A novel phosphoproteomic landscape evoked in response to type I interferon in the brain and in glial cells
  7. 10247
    “…Furthermore, bacterial communities formed at 6 or 12 weeks differed significantly among different CH(2)O levels. Functional analysis of bacterial communities showed that inferred genes related to chemical degradation and diseases were the highest in the 0.25 mg·m(−3) CH(2)O group at 12 weeks. …”
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    Effect of formaldehyde exposure on bacterial communities in simulating indoor environments
  8. 10248
    por Fang, Xisheng, Liu, Xia, Lu, Lin, Liu, Guolong
    Publicado 2021
    “…RESULTS: A total of 45 GInLncRNAs were screened out. Functional analysis showed that the functional genes of these GInLncRNAs were mainly enriched in chromosome and nucleoplasmic components, DNA binding in molecular function, transcription and complex anabolism in biological processes. …”
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    Identification of a Somatic Mutation-Derived Long Non-Coding RNA Signatures of Genomic Instability in Renal Cell Carcinoma
  9. 10249
    “…RESULTS: Untargeted proteomic and functional analysis using the KEGG showed that differentially expressed urinary proteins were primarily associated with the complement and coagulation cascades. …”
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    Urinary complement proteins and risk of end-stage renal disease: quantitative urinary proteomics in patients with type 2 diabetes and biopsy-proven diabetic nephropathy
  10. 10250
    “…We performed target gene prediction and functional analysis for candidate exosomal miRNAs. RESULTS: Compared with that in the MildA or SevereA group, an increase in exosomal miR-122-5p was found in the MildB or SevereB group, and the expression level was lower in the SevereB group than in the MildB group. …”
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    Exosomal miR-122-5p is Related to the Degree of Myelosuppression Caused by Chemotherapy in Patients with Colorectal Cancer
  11. 10251
    “…RESULTS: A total of 295 overlapping DEGs (ODEGs) (157 upregulated and 138 downregulated) and 9 hub genes were identified between primary melanoma and normal skin tissues. Functional analysis of these 9 hub genes indicated that the genes were primarily enriched in cell chemotaxis, the chemokine-mediated signaling pathway, the extracellular region, the extracellular space, chemokine activity and CXCR3 chemokine receptor binding. …”
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    Identification of Genes Potentially Associated with Melanoma Tumorigenesis Through Co-Expression Network Analysis
  12. 10252
    “…RESULTS: Fifty-seven circRNAs with differentially expressed m(6)A peaks were identified by m(6)A-modified RNA immunoprecipitation sequencing, of which 32 were upregulated and 25 downregulated. Functional analysis of these m(6)A circRNAs in SAP found some important pathways involved in the pathogenesis of SAP, such as regulation of autophagy and protein digestion. …”
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    Genome-wide map of N(6)-methyladenosine circular RNAs identified in mice model of severe acute pancreatitis
  13. 10253
    “…DEGs were functionally annotated using Gene Ontology (GO) functional analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. …”
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    Identification of a Novel Gene Correlated With Vascular Smooth Muscle Cells Proliferation and Migration in Chronic Thromboembolic Pulmonary Hypertension
  14. 10254
    “…Also, we conducted univariate and multivariate Cox regression analyses, and results indicated that the six-gene signature was an independent prognostic factor of cancer-specific survival of patients with BCa. Functional analysis was performed based on the differentially expressed genes of low- and high-risk patients, and we found that they were enriched in lipid metabolic and cell division-related biological processes. …”
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    Development and Validation of a Six-Gene Prognostic Signature for Bladder Cancer
  15. 10255
    “…Biophysical characterization of the cell-free synthetized IpaB and IpaH-CTD using SEC-MALS analysis showed well-defined oligomeric states of the proteins in solution. Functional analysis revealed similar immunoreactivity as compared to antigens purified from E. coli. …”
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    Efficient production of immunologically active Shigella invasion plasmid antigens IpaB and IpaH using a cell-free expression system
  16. 10256
    “…The other network contained 33 downregulated lncRNAs, 73 downregulated mRNAs, and 5 upregulated miRNAs. Functional analysis revealed that 38 GO terms and 8 pathways related with osteogenesis were enriched. …”
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    Comprehensive analysis of the long noncoding RNA-associated competitive endogenous RNA network in the osteogenic differentiation of periodontal ligament stem cells
  17. 10257
    “…Subcellular localization analysis revealed that downregulated DEPs of macrophages/monocytes were mostly located in the nucleus, whereas upregulated DEPs of foam cells/macrophages were mostly extracellular or located in the plasma membrane. Functional analysis of DEPs demonstrated that cholesterol metabolism-related proteins were upregulated in foam cells, whereas immune response-related proteins were downregulated in foam cells. …”
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    TMT-based quantitative proteomic profiling of human monocyte-derived macrophages and foam cells
  18. 10258
    “…Receiver operating characteristic (ROC) curve analysis and decision curve analysis (DCA) confirmed the signature's predictive value in the three cohorts. According to functional analysis, inflammation- and immune-related pathways and biological process could participate in the progression of IPF. …”
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    An 8-ferroptosis-related genes signature from Bronchoalveolar Lavage Fluid for prognosis in patients with idiopathic pulmonary fibrosis
  19. 10259
    “…Moreover, IRFs were positively correlated with the abundance of tumor infiltrating immune cells in PC, including B cells, CD8+ T cells, CD4+ T cells, macrophages, Neutrophil, and Dendritic cells. Functional analysis indicated that IRFs were involved in T cell receptor signaling pathway, immune response, and Toll-like receptor signaling pathway. …”
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    Comprehensive analysis of expression profile and prognostic significance of interferon regulatory factors in pancreatic cancer
  20. 10260
    “…It is advisable to conduct further functional analysis for a comprehensive knowledge on the contribution of this variant to the development of RA.…”
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    SLAMF6 is associated with the susceptibility and severity of rheumatoid arthritis in the Chinese population
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