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  1. 10341
    “…We not only successfully validated its feasibility, but also found that the 11 CR-based model was an independent prognostic factor. Functional analysis showed that CRs were mainly enriched in cancer development-related signalling pathways. …”
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    Establishing a prognostic model of chromatin modulators and identifying potential drug candidates in renal clear cell patients
  2. 10342
    “…Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis were used to conduct significantly functional analysis and crucial pathways. The resulting co-expression genes modules and hub genes were generated based on the weighted gene co-expression network analysis and visualization by Cytoscape. …”
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    Glutathione peroxidase 3 is a novel clinical diagnostic biomarker and potential therapeutic target for neutrophils in rheumatoid arthritis
  3. 10343
    “…After calculating CDR of active components in key functional network, the first 82 components covered 90.25% of the network information, which were defined as KFC. 82 KFC were subjected to functional analysis and experimental validation. 5–40 μM protocatechuic acid, 100–400 μM paeonol or caffeic acid exerted significant inhibitory activity on the proliferation of A549 cells. …”
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    Decoding the key compounds and mechanism of Shashen Maidong decoction in the treatment of lung cancer
  4. 10344
    “…METHODS: Differentially expressed genes (DEGs) were intersected with 484 ferroptosis markers to identify differentially expressed ferroptosis-related genes (DE-FRGs). Functional analysis and protein−protein interaction (PPI) networks were constructed to reveal the functions of DE-FRGs. …”
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    Identification and characterization of the ferroptosis-related ceRNA network in irreversible pulpitis
  5. 10345
    “…CONCLUSIONS: In addition to the key role of TMPSRSS2, we reported for the first time that higher expression levels of AR are related with a decreased risk of severe COVID-19 disease in females. Moreover, functional analysis demonstrates that ACE2, MX1 and TMPRSS2 are relevant markers in this disease. …”
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    Analyzing the role of ACE2, AR, MX1 and TMPRSS2 genetic markers for COVID-19 severity
  6. 10346
    “…RESULTS: We screened the top 15 hub genes and 3 core modules. Functional analysis showed that in the upregulated circRNA network, 15 hub genes were correlated with extracellular matrix organization and interaction. …”
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    Identification of novel prognostic circRNA biomarkers in circRNA-miRNA-mRNA regulatory network in gastric cancer and immune infiltration analysis
  7. 10347
    “…These lncRNA-miRNA pairs were regulating 87, 214, 499 and 435 differentially expressed mRNAs (DE mRNAs) in 2, 4, 6 and 8ppt treatments respectively. Functional analysis of these genes showed enrichment in pathways related to ion transportation and osmolyte production to cope with induced osmotic pressure due to high salt concentration. …”
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    Interplay of gene expression and regulators under salinity stress in gill of Labeo rohita
  8. 10348
    “…Further research could focus on the functional analysis of these genes, and their potential use in breeding programs to improve the salinity, drought, and disease resistance of this important crop.…”
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    Identification, characterization, and validation of NBS-encoding genes in grass pea
  9. 10349
    “…About 70% of these genes were unique to the two groups. Functional analysis of DEGs showed that neutrophil-mediated inflammation and mitochondrial dysfunction are the main features of ARDS induced by sepsis. …”
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    Network analysis identifies a gene biomarker panel for sepsis-induced acute respiratory distress syndrome
  10. 10350
    “…We performed gene annotation and gene functional analysis on the selected significant SNPs to determine the biological role of gene function and pathogenesis. …”
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    Exploring the novel SNPs in neuroticism and birth weight based on GWAS datasets
  11. 10351
    “…The aim of the study was to characterize functional and genetic mutations in X-linked CGD. METHODS: Functional analysis was conducted on the whole blood of seventeen male individuals who were suspected to have X-linked chronic granulomatous disease (CGD). …”
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    Novel mutations in CYBB Gene Cause X-linked chronic Granulomatous Disease in Pakistani patients
  12. 10352
    “…CONCLUSION: These results provide valuable information for characterizing the evolution, expansion, expression patterns and functional analysis, which help to understand the molecular mechanisms of the FvePLs in the development of strawberries. …”
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    Genome-wide identification and expression analyses of the pectate lyase (PL) gene family in Fragaria vesca
  13. 10353
    “…Conventional metaproteomics approaches largely rely on accurate identification of the MS/MS spectra to their corresponding short peptides in the digested samples, followed by protein inference and subsequent taxonomic and functional analysis of the detected proteins. These approaches are dependent on the availability of protein sequence databases derived either from sample-specific metagenomic data or from public repositories. …”
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    metaSpectraST: an unsupervised and database-independent analysis workflow for metaproteomic MS/MS data using spectrum clustering
  14. 10354
    “…A total of 37 DE-FRGs and 6 key CD-FRGs (CAV1, CD44, HIF1A, IFNG, TIMP1 and TLR4) were identified. GO and KEGG functional analysis indicated these genes enrichment in programmed cell death and apoptotic process, HIF-1 signaling pathway and IBD. …”
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    Exploration of key ferroptosis-related genes and immune infiltration in Crohn’s disease using bioinformatics
  15. 10355
    “…Another two external cohorts were used to confirm the prognostic effect of the above subtypes and risk score and meta-analysis was further conducted. Additionally, functional analysis, tumor stemness and heterogeneity and tumor microenvironment were also evaluated. …”
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    Senescence-associated secretory phenotype constructed detrimental and beneficial subtypes and prognostic index for prostate cancer patients undergoing radical prostatectomy
  16. 10356
    “…The inconsistency between genotype and phenotype of resistant genes indicated that the combination of resistance gene detection and functional analysis could better provide precision medicine for clinical use.…”
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    Characterization and Molecular Mechanism of Aminoglycoside-6-Adenyl Transferase Associated with Aminoglycoside Resistance from Elizabethkingia meningoseptica
  17. 10357
    “…RESULTS: Through sequence structure analysis, a total of 36 RWP-RK members were identified in elephant grass. Functional analysis revealed their close association with heat stress. …”
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    The evolution and expansion of RWP-RK gene family improve the heat adaptability of elephant grass (Pennisetum purpureum Schum.)
  18. 10358
    “…Herein, this study is aimed at constructing a ferroptosis-related prognostic signature for LUAD and conducting functional analysis based on the signature, highlighting the importance of ferroptosis in LUAD. …”
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    Construction and validation of a novel ferroptosis-related prognostic signature for lung adenocarcinoma
  19. 10359
    por Yuan, Qian, Zhang, Haiqiao
    Publicado 2023
    “…In addition, DEGs analysis was performed by Gene Ontology (GO) functional analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. …”
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    Identification of differentially expressed genes and pathways in BEAS-2B cells upon long-term exposure to particulate matter (PM(2.5)) from biomass combustion using bioinformatics analysis
  20. 10360
    “…Bioinformatic and functional analysis showed that ACSCs suppressed osteoarthritic osteoclasts formation, and inflammatory joint microenvironment augmented the inhibitory effects. …”
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    Human osteoarthritic articular cartilage stem cells suppress osteoclasts and improve subchondral bone remodeling in experimental knee osteoarthritis partially by releasing TNFAIP3
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