“…By contrast, the IRE1α/XBP1 axis upregulates the expression of Ufbp1 and ufmylation pathway genes in plasma cells, while Ufbp1 deficiency impairs ER expansion in plasma cells and retards immunoglobulin production. Structure and function analysis suggests that lysine 267 of Ufbp1, the main lysine in Ufbp1 that undergoes ufmylation, is dispensable for the development of plasmablasts, but is required for immunoglobulin production and stimulation of ER expansion in IRE1α-deficient plasmablasts. …”
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“…This genetic tool increases the ease, efficiency, and reliability of conditional mutagenesis and gene function analysis.…”
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“…Here, we conduct a structure–function analysis of the Drosophila Citron kinase, Sticky, in Schneider’s S2 cells. …”
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“…The nanostructure of the composites was probed using pair distribution function analysis and scanning transmission electron microscopy. …”
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“…Furthermore, structure-function analysis illustrates how destabilization of the melted DNA region correlates with contraction of the polymerase cleft upon transcription activation, thereby combining promoter recruitment with DNA-melting. …”
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“…Differential item functioning analysis was adopted to check possible item bias caused by responses from different subgroups based on sex and ethnicity. …”
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“…Gain- and loss-of-function analysis indicates that upregulation of Abi1 mediates PTEN loss-induced EMT and CSC activity. …”
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“…Here, we use in operando X-ray pair distribution function analysis combining with our recently developed analytical approach employing Metropolis Monte Carlo simulations and non-negative matrix factorisation to study the charge reaction thermodynamics of a series of Fe- and Mn-oxides. …”
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“…We validate this new implementation on a series of FFS analyses: spot-variation fluorescence correlation spectroscopy, pair-correlation function analysis, and image-derived mean squared displacement analysis. …”
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“…Second, we applied a cyclostationary empirical orthogonal function analysis (CSEOF). Although the CSEOF technique is distinct from the least-squares regression in that it does not consider proxies, each method produces two modes (decadal and interannual), showing consistency with each technique in spatial pattern and its evolution amplitudes. …”
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“…The Cre/LoxP-based conditional knockout technology is a powerful tool for gene function analysis that allows region- and time-specific gene manipulation. …”
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“…Moreover, somatic expression of TEX12 is aberrantly activated via retinoic acid signalling, which is commonly disregulated in cancer. Structure-function analysis reveals that phosphorylation of TEX12 on tyrosine 48 is important for centrosome amplification but not for recruitment of TEX12 to centrosomes. …”
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“…Here we describe a comparative structure-function analysis of C10 bound to the envelope (E) protein dimers of the five viruses it neutralizes. …”
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“…In the present study, we attempted a loss-of-function analysis of zebrafish Klf11a and Klf11b, which constitute human KLF10 homologs. …”
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“…The second part deals with the description and function analysis of all car subsystems, such as: ·         vehicle body, ·         chassis, including wheels, suspensions, brakes and steering mechanisms, ·         diesel and gasoline engines, ·         electric motors, batteries, fuel cells, hybrid propulsion systems, ·         driveline, including manual and automatic gearboxes. …”
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“…For example, various applications in function analysis concerning Abelian and Tauberian theorems can be studied as well as those in studies of the asymptotic behavior of solutions of stochastic differential equations. …”
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“…The following manuscript describes the evaluation of this library against HSV-1, as well as a subset against HSV-2. The structure–function analysis obtained from these studies demonstrates the importance of lipophilicity and rigidity to αHT-based anti-HSV potency, consistent with our prior work on smaller libraries. …”
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“…Effective spatial resolution was determined via modulation transfer function analysis. Dispersion vs. absorption (DISPA) analysis and full width at half maximum (FWHM) quantified spectral lineshape changes. …”
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“…A significant MANOVA was followed up using Discriminant Function Analysis (DFA). A significant main effect was found for information source. …”
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“…Gain- and loss-of- function analysis further confirmed that GSDMD regulated the pyroptosis of murine aortic vascular smooth muscle cells (MOVAS) in an in vitro model of tumor necrosis factor (TNF)-α treatment, which was achieved by transfecting expressing plasmid or siRNA, respectively. …”
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