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  1. 11301
    “…None of the dogs showed evidence of tumors or altered liver function. Analysis of integration sites in liver samples from six treated dogs identified 1,741 unique AAV integration events in genomic DNA and expanded cell clones in five dogs, with 44% of these integrations near genes involved in cell growth. …”
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    A long-term study of AAV gene therapy in hemophilia A dogs identifies clonal expansions of transduced liver cells
  2. 11302
    “…These proteins may comprise a network that regulates male sterility in wheat. Based on the function analysis of DEPs involved in the complex network, we concluded that the P-type CMS line may be due to cellular dysfunction caused by disturbed carbohydrate metabolism, inadequate energy supply, and disturbed protein synthesis. …”
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    Comparative Proteomic Analysis of Developmental Changes in P-Type Cytoplasmic Male Sterile and Maintainer Anthers in Wheat
  3. 11303
    por Wu, Di, Pan, Yun, Zheng, Xueyong
    Publicado 2021
    “…Prognostic value of risk model has been verified in TCGA-HCC and GSE76240 datasets. Biological function analysis revealed these hub genes were closely associated with tumorigenesis processes. …”
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    Identification of hub genes-based predictive model in hepatocellular carcinoma by robust rank aggregation and regression analysis
  4. 11304
    “…Methods: In forty healthy adults, flow velocity was monitored in the anterior, middle, and posterior cerebral arteries, and synchronized with arterial blood pressure. A transfer function analysis provided characteristics of autoregulation by quantifying the relationship between blood pressure and cerebral blood flow velocity. …”
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    Differentiating Dynamic Cerebral Autoregulation Across Vascular Territories
  5. 11305
    “…We analysed 269 whistle alarms produced by 13 individuals and 591 wideband alarms from 25 individuals at the western part of Lake Baikal. A discriminant function analysis (DFA) assigned 93.5% (88.9%, cross-validated result) of whistle alarms to the correct individual and 91.4% (84%) of wideband alarms. …”
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    Individual-based acoustic variation of the alarm calls in the long-tailed ground squirrel
  6. 11306
    “…The study aimed to highlight the profitability and production function analysis of Penaeus monodon and Litopenaeus vannamei in intensified shrimp farms in Gujarat (India). …”
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    Comparative analysis of profitability and resource use efficiency between Penaeus monodon and Litopenaeus vannamei in India
  7. 11307
    “…To examine RLP function in growth and development, we performed loss-of-function analysis using a virus-induced gene silencing system. …”
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    Tissue-Specific RNA-Seq Analysis and Identification of Receptor-Like Proteins Related to Plant Growth in Capsicum annuum
  8. 11308
    “…In this study, we verified the detailed characteristics of transgene expression and plasmid DNA (pDNA) in mice to develop therapeutic strategies and application to gene function analysis in the kidney. After naked pDNA was administered intravenously, the right kidney was immediately suctioned by a tissue suction device. …”
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    Characterization of transgene expression and pDNA distribution of the suctioned kidney in mice
  9. 11309
    “…By using a Master Stability Function analysis combined with numerical simulations, we find that delays (1) may actually stabilize brain dynamics by temporarily preventing the onset to oscillatory and pathologically synchronized dynamics and (2) may enhance or diminish synchronization depending on the underlying eigenvalue spectrum of the connectivity matrix. …”
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    The Impact of Small Time Delays on the Onset of Oscillations and Synchrony in Brain Networks
  10. 11310
    “…Predicting the quaternary structure of protein complexes is useful for protein function analysis, protein engineering, and drug design. …”
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    DeepComplex: A Web Server of Predicting Protein Complex Structures by Deep Learning Inter-chain Contact Prediction and Distance-Based Modelling
  11. 11311
    “…However, probiotic supplementation did not affect most factors except pH. In functionality analysis, the yogurt co-fermented with probiotics and ginseng showed the highest antioxidant activity and gene expression levels of the immune-related factors TNF-α and iNOS in RAW 264.7 cells. …”
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    Co-Fermentation by Lactobacillus brevis B7 Improves the Antioxidant and Immunomodulatory Activities of Hydroponic Ginseng-Fortified Yogurt
  12. 11312
    “…Stepwise discriminant function analysis was performed for all measurements and specified separately to the proximal and distal radius. …”
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    Sex estimation using radius in a Thai population
  13. 11313
    “…Such stability is achieved through the in situ conversion reaction, which was herein unambiguously confirmed by pair distribution function analysis of cycled SiN(x) nanoparticles revealing that active silicon domains and a stabilizing Li(2)SiN(2) phase are formed in situ during the initial lithiation.…”
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    Stoichiometry-Controlled Reversible Lithiation Capacity in Nanostructured Silicon Nitrides Enabled by in Situ Conversion Reaction
  14. 11314
    por Tian, Xiaolin
    Publicado 2021
    “…The Mask‐induced lifespan extension appears to depend on the function of Mask to regulate microtubule (MT) stability. A structure–function analysis demonstrated that the ankyrin repeats domain in the Mask protein is both necessary for regulating MT stability (when expressed in muscles and motor neurons) and sufficient to prolong longevity (when expressed in the two groups of DANs). …”
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    Enhancing mask activity in dopaminergic neurons extends lifespan in flies
  15. 11315
    “…Thus, our method complements current in vivo techniques by enabling optogenetic-assisted structure–function analysis of single neurons recorded during natural, unrestrained behavior.…”
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    Juxtacellular opto-tagging of hippocampal CA1 neurons in freely moving mice
  16. 11316
    “…Additionally, gene function analysis aspect of the function annotation, effector, and virulence were concluded that total of 3367 cluster of orthologous groups of proteins genes and classified into 24 categories, while the most outstanding class was metabolic process (1533) and catalytic activity (1498). …”
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    Complete genome sequence of the Clostridium difficile LCL126
  17. 11317
    “…When entered into a full-model discriminant function analysis, elbow angle, elbow height, and release angle variables correctly classified PRO from N-PRO 2-point shooters in 62.1% of cases and hip angle, heel height, and elbow angle variables correctly classified PRO from N-PRO 3-point shooters in 81.6% of cases.…”
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    Kinetic and Kinematic Characteristics of Proficient and Non-Proficient 2-Point and 3-Point Basketball Shooters
  18. 11318
    por Dai, Weijun, Shi, Yi, Hu, Weiqi, Xu, Chenjie
    Publicado 2022
    “…Interestingly, loss-of-function analysis revealed that FAM225B knockdown significantly inhibited tumor growth in vitro and in vivo, and decreased the migratory and invasive capacity of NPC cells. …”
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    Long noncoding RNA FAM225B facilitates proliferation and metastasis of nasopharyngeal carcinoma cells by regulating miR-613/CCND2 axis
  19. 11319
    “…Through additional genetic loss of function analysis, we show that within each pharyngeal neuron class, ceh-34 cooperates with different homeodomain transcription factors to individuate distinct pharyngeal neuron classes. …”
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    The enteric nervous system of the C. elegans pharynx is specified by the Sine oculis-like homeobox gene ceh-34
  20. 11320
    “…Gain-of-function and loss-of-function analysis confirmed that age-related downregulation of CCN2 is regulated by YAP/TAZ in response to reduced cell size. …”
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    Age-Related Downregulation of CCN2 Is Regulated by Cell Size in a YAP/TAZ-Dependent Manner in Human Dermal Fibroblasts: Impact on Dermal Aging
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