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  1. 11361
    “…Additional structure-function analysis reveals that Q588 forms a regulatory site in UBE3A that is conserved among HECT domain ubiquitin ligases and perturbed in various neurodevelopmental disorders. …”
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    Identification of disease-linked hyperactivating mutations in UBE3A through large-scale functional variant analysis
  2. 11362
    “…Here we present a detailed structure-function analysis of TRIM2 and TRIM3, which despite high sequence identity, exhibit markedly different self-association and activity profiles. …”
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    Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity
  3. 11363
    “…This study uses import demand function analysis to look at how the major mineral importing countries’ mineral import demand changed in response to the clean energy transitions between 2000 and 2021 for selected 14 countries. …”
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    How do strategic mineral resources affect clean energy transition? Cross-sectional autoregressive distributed lag (CS-ARDL) approach
  4. 11364
    “…Inhibition of PfACS10 leads to a reduction in triacylglycerols and a buildup of its lipid precursors, providing key insights into its function. Analysis of the PfACS11 gene and its mutations point to a role in mediating resistance via decreased protein stability.…”
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    Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation
  5. 11365
    “…We conclude that CPET and lung function analysis should be used consistently to evaluate the cause of dyspnea and for long-term observation.…”
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    Primary mitochondrial disease as a rare cause of unclear breathlessness and distinctive performance degradation – a case report
  6. 11366
    “…Biochemical experiments showed that ISG20-mediated degradation of 2′O-methylated RNA pauses two nucleotides upstream of and at the methylated residue. Structure-function analysis indicated that this inhibition is due to steric clash between ISG20 R53 and D90 residues and the 2′O-methylated nucleotide. …”
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    Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect
  7. 11367
    “…Importantly, to date, there is a very limited structure–function analysis of these structures within whole bacteria. …”
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    Engineering nanowires in bacteria to elucidate electron transport structural–functional relationships
  8. 11368
    “…Currently, missing structural and related functional understanding limits patient mutation interpretation to homology-directed repair (HDR) function analysis. Here we report the RAD51C-XRCC3 (CX3) X-ray co-crystal structure with bound ATP analog and define separable RAD51C replication stability roles informed by its three-dimensional structure, assembly, and unappreciated polymerization motif. …”
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    RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles
  9. 11369
    “…Here we describe a detailed structure-function analysis of LYS-S8-19, a 1′,5′-anhydrohexitol nucleic acid (HNA) aptamer to hen egg-white lysozyme (HEL). …”
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    Characterization of an HNA aptamer suggests a non-canonical G-quadruplex motif
  10. 11370
    “…The phosphorylation status of the mature 170 kD P-glycoprotein and the surface localisation of this glycoprotein showed the strongest correlation with functionality. Analysis of cell lines for cross-resistance and chemosensitivity profiles against a battery of chemotherapeutic drugs suggests multiple mechanisms, in addition to Pgp, contribute to the overall resistance of colorectal cancer. …”
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    Constitutive expression of multidrug resistance in human colorectal tumours and cell lines.
  11. 11371
    “…We used 2-step cluster analysis to identify objective call types and discriminant function analysis to assess context specificity. Alarm calls given in response to leopards, eagles, and snakes could be well distinguished, while the inclusion of calls given in aggressive contexts yielded some overlap, specifically between female calls given to snakes, eagles and during aggression, as well as between male vervet barks (additionally recorded in South Africa) in leopard and aggressive contexts. …”
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    Vervets revisited: A quantitative analysis of alarm call structure and context specificity
  12. 11372
    “…‘Intermediate’ subtype that constitutes a very small percentage in circulation (under physiological conditions) appear to be transitional monocytes that display both phagocytic and inflammatory function. Analysis of blood from patients with Sepsis, a pathogen driven acute inflammatory disease and Systemic Lupus Erythmatosus (SLE), a chronic inflammatory disorder validated the broad conclusions drawn in the study.…”
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    Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous
  13. 11373
    “…Then, following a strict rational selection scheme including homology analysis, disturbance analysis, function analysis and transcript abundance analysis, 13 candidates were selected from the 1,471 genes. …”
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    Genome-wide identification and characterization of reference genes with different transcript abundances for Streptomyces coelicolor
  14. 11374
    “…METHODOLOGY/PRINCIPAL FINDINGS: We hypothesized that advanced numerical and biological function analysis methods would help elucidate the inflammatory response to skin and muscle wounds in rats, both with and without concomitant shock. …”
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    Cardiac Arrest Disrupts Caspase-1 and Patterns of Inflammatory Mediators Differently in Skin and Muscle Following Localized Tissue Injury in Rats: Insights from Data-Driven Modeling
  15. 11375
    “…The acoustic parameters showing PIC ≥ 1.1 were used to perform a stepwise cross-validated discriminant function analysis (DFA). The DFA correctly classified 66.1% of the contact calls and 62.5% of display songs to the correct individual. …”
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    Vocal individuality cues in the African penguin (Spheniscus demersus): a source-filter theory approach
  16. 11376
    “…Furthermore, we performed a structure-function analysis of Dlg5 and found that the C-terminal PDZ3 and PDZ4 domains are required for all Dlg5’s functions as well as its ability to localize to apical membrane. …”
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    Dlg5 maintains apical polarity by promoting membrane localization of Crumbs during Drosophila oogenesis
  17. 11377
    “…We used genome-wide transcriptome analysis to identify a subset of the type 2C protein phophatase (PP2C) genes that are specifically up-regulated in Rsv3-mediated ER. Gain-of-function analysis of the most significantly expressed soybean PP2C gene, GmPP2C3a, showed that ABA-induced GmPP2C3a functions as a key regulator of Rsv3-mediated ER. …”
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    Type 2C Protein Phosphatase Is a Key Regulator of Antiviral Extreme Resistance Limiting Virus Spread
  18. 11378
    “…In addition, Diseases and Functions analysis suggested that these cellular proteins are highly related with Organismal Injury and Abnormalities and Cell Death and Survival. …”
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    Generation and Comprehensive Analysis of Host Cell Interactome of the PA Protein of the Highly Pathogenic H5N1 Avian Influenza Virus in Mammalian Cells
  19. 11379
    por Choi, Woosuk, Kim, Kwang-Yul
    Publicado 2018
    “…Here we show the impact of boreal warming on the spring and early summer drought over North America using Cyclostationary Empirical Orthogonal Function analysis. Northern Hemispheric warming, the leading mode of the surface air temperature variability, has led to a decrease in precipitation, evaporation and moisture transport over the central plain of North America. …”
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    Physical mechanism of spring and early summer drought over North America associated with the boreal warming
  20. 11380
    “…In the current studies, we performed a structure–function analysis, which indicated that the fibronectin type III (FN) domain and the intracellular domain of Tril are required to trigger Smad7 degradation in Xenopus embryos. …”
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    Fibronectin type III and intracellular domains of Toll-like receptor 4 interactor with leucine-rich repeats (Tril) are required for developmental signaling
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