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  1. 11581
    “…Generation of liver-specific ATGL knockouts has implicated hepatic lipolysis as a critical component of normal liver function. Analysis of β-cell ATGL knockouts implicates the necessity of pancreatic ATGL in insulin secretion. …”
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    The role of adipose triglyceride lipase in lipid and glucose homeostasis: lessons from transgenic mice
  2. 11582
    “…CA function was evaluated by transfer function analysis based on spontaneous oscillation of cerebral blood flow and arterial blood pressure. …”
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    Compromised Dynamic Cerebral Autoregulation in Patients With Idiopathic Rapid Eye Movement Behavior Disorder: A Case-Control Study Using Transcranial Doppler
  3. 11583
    por Wollenberg Valero, Katharina C.
    Publicado 2020
    “…RESULTS: A discriminant function analysis lent statistical support to classifying the yeast interactome into hub, intermediate and peripheral nodes based on network neighborhood connectivity, betweenness centrality, and average shortest path length. …”
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    Aligning functional network constraint to evolutionary outcomes
  4. 11584
    “…Genome editing technology represented by CRISPR-Cas9 had been widely used in many biological fields such as gene function analysis, gene therapy, and crop improvement. …”
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    The Improvement of CRISPR-Cas9 System With Ubiquitin-Associated Domain Fusion for Efficient Plant Genome Editing
  5. 11585
    “…Additionally, the altered glutathione metabolism and purine metabolism pathways were identified by both metagenomic function analysis and metabolite pathway enrichment analysis. …”
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    Integrated Metagenomic and Metabolomic Analyses of the Effect of Astragalus Polysaccharides on Alleviating High-Fat Diet–Induced Metabolic Disorders
  6. 11586
    “…Variant analysis of whole-genome sequence data identified two SNPs in the 3′UTR of the LY49B gene that may result in loss of function. Analysis of transcriptomic data from equine embryonic tissue revealed that LY49B is expressed in the trophoblast during placentation stage of development. …”
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    A genome-wide scan for candidate lethal variants in Thoroughbred horses
  7. 11587
    “…Functionally, gain- and loss-of-function analysis showed that PGAM1 promoted proliferation and invasion in vitro, and facilitated tumor growth in vivo. …”
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    PGAM1, regulated by miR-3614-5p, functions as an oncogene by activating transforming growth factor-β (TGF-β) signaling in the progression of non-small cell lung carcinoma
  8. 11588
    “…We performed pulmonary inflammation evaluation, morphometric measurements, and lung function analysis in rat lung at three different times points during exposure. …”
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    Chronic exposure to ambient particulate matter induces gut microbial dysbiosis in a rat COPD model
  9. 11589
    “…OCA revealed that the invasive melanoma has a higher vessel density and thicker blood vessels than melanoma in situ and benign lesions. Discriminant functions analysis of MPM and OCA data allowed to differentiate correctly between all equivocal melanocytic lesions. …”
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    In vivo multimodal optical imaging of dermoscopic equivocal melanocytic skin lesions
  10. 11590
    “…We performed gain-and loss-of-function analysis and found that TMPRSS4 promotes cellular proliferation and inhibits apoptosis of PDAC cells both in vitro and in vivo. …”
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    TMPRSS4 Promotes Cell Proliferation and Inhibits Apoptosis in Pancreatic Ductal Adenocarcinoma by Activating ERK1/2 Signaling Pathway
  11. 11591
    “…To identify the molecular effectors that govern IFN control of SARS-CoV-2 infection, we conducted a large-scale gain-of-function analysis that evaluated the impact of human IFN-stimulated genes (ISGs) on viral replication. …”
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    Functional landscape of SARS-CoV-2 cellular restriction
  12. 11592
    “…We used three methods to compare the level of individual distinctiveness across call types, namely discriminant function analysis (DFA), potential for individual identity coding (PIC), and the information criterion (H(s)). …”
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    Individual distinctiveness across call types of the southern white rhinoceros (Ceratotherium simum simum)
  13. 11593
    “…To understand the mechanism of mouse CLC-2 opening we used homology modelling-guided structure–function analysis. Structural modelling suggests that glutamate E213 interacts with tyrosine Y561 to close a pore. …”
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    Electro-steric opening of the clc-2 chloride channel gate
  14. 11594
    “…These results demonstrate that hairpin detection is a promising avenue for global and rapid structure-function analysis, furthering our understanding of RNA biology and the principal features which drive biological insights from SP data.…”
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    Rapid structure-function insights via hairpin-centric analysis of big RNA structure probing datasets
  15. 11595
    “…The dynamic cerebral autoregulation (CA) index (ARI) was extracted with transfer function analysis from the CBFV step response to the BP input and step responses were also obtained for the BP-CrCP and BP-RAP relationships. …”
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    Cerebral critical closing pressure and resistance-area product: the influence of dynamic cerebral autoregulation, age and sex
  16. 11596
    “…Overall, our systematic analysis of GhFBA genes would not only provide a basis for the understanding of the evolution of GhFBAs, but also found a foundation for the further function analysis of GhFBAs to improve cotton yield and environmental adaptability.…”
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    Genome-Wide Characterization and Expression Analysis Provide Basis to the Biological Function of Cotton FBA Genes
  17. 11597
    “…To understand this, we generated 674 mAbs from Beta-infected individuals and performed a detailed structure-function analysis of the 27 most potent mAbs: one binding the spike N-terminal domain (NTD), the rest the receptor-binding domain (RBD). …”
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    The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants
  18. 11598
    “…Selected indicators showed good diagnostic performance for identifying the extent of the wound and wound age in a Fisher discriminant analysis. A function analysis showed that the candidate genes were mainly related to cell proliferation and the inflammatory response, primarily IL-17 and the Hematopoietic cell lineage signalling pathway. …”
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    Identifying biomarkers for evaluating wound extent and age in the contused muscle of rats using microarray analysis: a pilot study
  19. 11599
    “…Additionally, this efficient, fast, and stable transformation system could be a potential tool for gene function analysis and forest tree genetic improvement.…”
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    Efficient Transformation of Catalpa bungei Shows Crystal Genes Conferring Resistance to the Shoot Borer Omphisa plagialis
  20. 11600
    “…We then performed Gene Ontology (GO) and KEGG analysis to systematically characterize the ten significantly differentially methylated genes: PTPRN2, MAD1L1, TNXB, PRDM16, GNAS, KCNQ1, TSNARE1, HDAC4, TBCD, and DIP2C. Meanwhile, function analysis of genes with differentially methylated sites located in promoter regions of overlap group was also performed. …”
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    Pancreatic cancer differential methylation atlas in blood, peri-carcinomatous and diseased tissue
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