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  1. 11941
    “…Functional measurements of Ca(2+) influx through mutant TRPV4 channels in HEK293 cells and patient-derived dermal fibroblasts identified a TRPV4 gain of function. Analysis of channel open times, determined indirectly from measurement of TRPV4 activity within a cluster of TRPV4 channels, revealed that the TRPV4 gain of function was caused by longer channel openings. …”
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    Gain-of-function mutation in TRPV4 identified in patients with osteonecrosis of the femoral head
  2. 11942
    “…In line with the observed pro-migratory effect of exosomes isolated from irradiated cells protein function analysis assigned the deregulated exosomal proteins to cell motility and AKT-signalling. …”
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    Radiation alters the cargo of exosomes released from squamous head and neck cancer cells to promote migration of recipient cells
  3. 11943
    “…However, OG presented an increased body mass, inguinal, retroperitoneal and epididymal adipose tissues, as well as body adiposity index at the end of experimental protocol. In erectile function analysis, there was a decrease in the number and the latency of penile erections in OG. …”
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    Hypercaloric Diet Establishes Erectile Dysfunction in Rat: Mechanisms Underlying the Endothelial Damage
  4. 11944
    “…Additionally, in vitro experiments with loss-of function analysis using human gingival epithelial cells confirmed the important role of α6(IV) chain in epithelial keratinization. …”
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    Type IV collagen α6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium
  5. 11945
    por Prins, Bram P., Mead, Timothy J., Brody, Jennifer A., Sveinbjornsson, Gardar, Ntalla, Ioanna, Bihlmeyer, Nathan A., van den Berg, Marten, Bork-Jensen, Jette, Cappellani, Stefania, Van Duijvenboden, Stefan, Klena, Nikolai T., Gabriel, George C., Liu, Xiaoqin, Gulec, Cagri, Grarup, Niels, Haessler, Jeffrey, Hall, Leanne M., Iorio, Annamaria, Isaacs, Aaron, Li-Gao, Ruifang, Lin, Honghuang, Liu, Ching-Ti, Lyytikäinen, Leo-Pekka, Marten, Jonathan, Mei, Hao, Müller-Nurasyid, Martina, Orini, Michele, Padmanabhan, Sandosh, Radmanesh, Farid, Ramirez, Julia, Robino, Antonietta, Schwartz, Molly, van Setten, Jessica, Smith, Albert V., Verweij, Niek, Warren, Helen R., Weiss, Stefan, Alonso, Alvaro, Arnar, David O., Bots, Michiel L., de Boer, Rudolf A., Dominiczak, Anna F., Eijgelsheim, Mark, Ellinor, Patrick T., Guo, Xiuqing, Felix, Stephan B., Harris, Tamara B., Hayward, Caroline, Heckbert, Susan R., Huang, Paul L., Jukema, J. W., Kähönen, Mika, Kors, Jan A., Lambiase, Pier D., Launer, Lenore J., Li, Man, Linneberg, Allan, Nelson, Christopher P., Pedersen, Oluf, Perez, Marco, Peters, Annette, Polasek, Ozren, Psaty, Bruce M., Raitakari, Olli T., Rice, Kenneth M., Rotter, Jerome I., Sinner, Moritz F., Soliman, Elsayed Z., Spector, Tim D., Strauch, Konstantin, Thorsteinsdottir, Unnur, Tinker, Andrew, Trompet, Stella, Uitterlinden, André, Vaartjes, Ilonca, van der Meer, Peter, Völker, Uwe, Völzke, Henry, Waldenberger, Melanie, Wilson, James G., Xie, Zhijun, Asselbergs, Folkert W., Dörr, Marcus, van Duijn, Cornelia M., Gasparini, Paolo, Gudbjartsson, Daniel F., Gudnason, Vilmundur, Hansen, Torben, Kääb, Stefan, Kanters, Jørgen K., Kooperberg, Charles, Lehtimäki, Terho, Lin, Henry J., Lubitz, Steven A., Mook-Kanamori, Dennis O., Conti, Francesco J., Newton-Cheh, Christopher H., Rosand, Jonathan, Rudan, Igor, Samani, Nilesh J., Sinagra, Gianfranco, Smith, Blair H., Holm, Hilma, Stricker, Bruno H., Ulivi, Sheila, Sotoodehnia, Nona, Apte, Suneel S., van der Harst, Pim, Stefansson, Kari, Munroe, Patricia B., Arking, Dan E., Lo, Cecilia W., Jamshidi, Yalda
    Publicado 2018
    “…In vitro validation analysis shows that the QRS-associated variants lead to impaired ADAMTS6 secretion and loss-of function analysis in mice demonstrates a previously unappreciated role for ADAMTS6 in connexin 43 gap junction expression, which is essential for myocardial conduction. …”
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    Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6
  6. 11946
    “…Based on the enriched pathways and molecular function analysis, 12 DEGs related to eggshell mineralization were further analyzed in the uteri of layers (3 h and 15–20 h post-ovulation), non-layers and molters using qPCR. …”
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    RNA sequencing-based analysis of the laying hen uterus revealed the novel genes and biological pathways involved in the eggshell biomineralization
  7. 11947
    “…These results suggest that both desialylation and apoptosis may be relevant mechanisms leading to platelet destruction although, they do not interfere with MK function. Analysis of these thrombocytopenic factors in individual patients showed no specific distribution pattern. …”
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    Multiple concomitant mechanisms contribute to low platelet count in patients with immune thrombocytopenia
  8. 11948
    “…Loss- or gain-of-function analysis showed that CDH2 significantly promoted in vitro and in vivo angiogenesis and sensitivity to the antagonist exherin. …”
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    Tumor endothelial cell-derived cadherin-2 promotes angiogenesis and has prognostic significance for lung adenocarcinoma
  9. 11949
    “…CA was evaluated by transfer function analysis and by the autoregulatory index (Mxa) in order to determine the relationship between mean cerebral blood flow velocity and mean arterial blood pressure. …”
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    Effects of Resistance Exercise and Nutritional Supplementation on Dynamic Cerebral Autoregulation in Head-Down Bed Rest
  10. 11950
    “…CCK-8, colony formation, flow cytometry and transwell assays were performed for the function analysis of HLA complex group 11 (HCG11). The mechanism study for HCG11 was conducted using RIP, RNA pull down and luciferase reporter assays. …”
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    LncRNA HCG11 promotes proliferation and migration in gastric cancer via targeting miR-1276/CTNNB1 and activating Wnt signaling pathway
  11. 11951
    “…Autoregulation index (ARI) was calculated from the CBFV response to a step change in BP derived by transfer function analysis. RESULTS: In 67 patients, mean age 64.3 ± 9.5 years, CA was depressed at T2 as shown by values of ARI (3.9 ± 1.7), compared to T1 (5.6 ± 1.7) and T3 (5.5 ± 1.8) (p < 0.001). …”
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    Dynamic cerebral autoregulation: A marker of post-operative delirium?()
  12. 11952
    “…We perform structure/function analysis of Tbx2 to elucidate the roles of both Tbx2-Smad interaction and Tbx2 DNA-binding in germ layer suppression. …”
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    Tbx2 mediates dorsal patterning and germ layer suppression through inhibition of BMP/GDF and Activin/Nodal signaling
  13. 11953
    “…The remaining trials were a mixture of biological agents, radiation optimisation, diagnostic imaging, surgical intervention, and a social function analysis. CONCLUSION: OPG is a complex multifaceted disease, and advances in care require ongoing research efforts across a spectrum of different research fields. …”
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    A systematic review of ongoing clinical trials in optic pathway gliomas
  14. 11954
    “…Then immune-related genes were identified, followed by function analysis, transcription factor (TF)-miRNA–mRNA co-regulatory network analysis, and survival analysis of metastatic recurrence. …”
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    Genomic landscape of the immune microenvironments of brain metastases in breast cancer
  15. 11955
    “…Student T test and discriminate function analysis have been used in statistical analysis. …”
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    Identification of motives and barriers to physical activity of polish young mothers
  16. 11956
    “…Version 3 or 4 of Wechsler Intelligent Scale for Children (WISC) was used by neurocognitive function analysis. Ventricular size, white matter volume and other parameters were also was estimated based on MRI. …”
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    QOL-44. ASSESSMENT OF NEUROCOGNITIVE FUNCTION AND MRI PARAMETERS IN LONG-TERM SURVIVORS WITH POSTERIOR FOSSA TUMORS: A COMPARISON BETWEEN MEDULLOBLASTOMAS TREATED BY REDUCED-DOSE CRANIOSPINAL IRRADIATION AND OTHER TUMORS
  17. 11957
    “…We discuss roles for geriatricians in ten stages of the vaccine development process, covering vaccine design, trial design, trial recruitment, establishment and interpretation of illness definitions, safety monitoring, consideration of relevant health measures such as frailty and function, analysis methods to account for frailty and differential vulnerability, contributions in regulatory and advisory roles, post-marketing surveillance, and program implementation and public health messaging. …”
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    Considering Frailty in SARS-CoV-2 Vaccine Development: How Geriatricians Can Assist
  18. 11958
    “…Higher METTL1 expression was associated with high-grade tumors and poor disease prognosis. Loss-of-function analysis in tumor cell lines indicated the biological importance of METTL1, an m(7)G methyltransferase, in cancer cell growth and survival. …”
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    Multi-omics integration of methyltransferase-like protein family reveals clinical outcomes and functional signatures in human cancer
  19. 11959
    “…CONCLUSIONS: We present methods and resources, generated using REMI-seq, for high throughput gene function analysis in a key model system. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12915-021-01108-y.…”
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    Mutant resources for functional genomics in Dictyostelium discoideum using REMI-seq technology
  20. 11960
    “…CONCLUSIONS: A comprehensive lung function analysis and in case of restrictive lung disorders additional CT scans are needed in RCF exposed workers in accordance to the guidelines for medical occupational examinations comparable to asbestos exposed workers.…”
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    Rounded atelectasis after exposure to refractory ceramic fibres (RCF)
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