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  1. 11981
    “…Statistical analysis was evaluated based on the features extracted from the whole brain, as determined using discriminant function analysis and support vector machine. 20% of the participants were used as an independent blind dataset with 5 times cross-verification. …”
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    Diffusion tensor imaging for the differential diagnosis of Parkinsonism by machine learning
  2. 11982
    “…METHODS: Survival function analysis on a retrospective cohort of patients with advanced HF followed at the outpatient clinic of Hospital Universitario San Ignacio (Bogotá, Colombia) between 2017 and 2021. …”
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    Evaluation of diuretic efficiency of intravenous furosemide in patients with advanced heart failure in a heart failure clinic
  3. 11983
    “…Anti-pulmonary fibrosis effect of hucMSCs therapy by reducing mechanical stiffness was evaluated by lung function analysis and MicroCT imaging system and atomic force microscope in vivo and in vitro. …”
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    hucMSCs treatment prevents pulmonary fibrosis by reducing circANKRD42-YAP1-mediated mechanical stiffness
  4. 11984
    “…Furthermore, metagenomics function analysis and metabolic pathway enrichment analysis revealed that ASH might influence unsaturated fatty acid synthesis and purine metabolism pathways. …”
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    Acanthopanax senticosus Harms improves Parkinson's disease by regulating gut microbial structure and metabolic disorders
  5. 11985
    “…In 33 healthy adults and 17 acute ischemic stroke patients, resting-state hemodynamic were monitored simultaneously with high-speed (20 Hz) DCS and TCD. dCA parameters were calcaulated by a transfer function analysis using a Fourier decomposition of ABP and CBF (or CBF-velocity). …”
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    Dynamic cerebral autoregulation measured by diffuse correlation spectroscopy
  6. 11986
    “…Cell counting kit‐8, 5‐ethynyl‐2′‐deoxyuridine (EdU), and flow cytometry were applied for function analysis. The interaction between miR‐150‐5p and circ_0008285 or brain acid‐soluble protein 1 (BASP1) was also evaluated by dual‐luciferase reporter assay and RNA immunoprecipitation assay. …”
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    Circ_0008285 silencing suppresses angiotensin II‐induced vascular smooth muscle cell apoptosis in thoracic aortic aneurysm via miR‐150‐5p/BASP1 axis
  7. 11987
    “…It also suppressed the expression of IL‐1β (LPS 132.6 ± 14.6, EGCG 10.67 ± 3.65), IL‐6 (LPS 2994.44 ± 178.5, EGCG 408.33 ± 52.34), TNF‐α (LPS 27.11 ± 2.84, EGCG 1.22 ± 0.03), and iNOS (LPS 40.45 ± 11.17, EGCG 10.24 ± 0.89). The GO function analysis identified that these differential genes involved 24 biological processes, 18 molecular functions, and 19 cellular component‐related processes. …”
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    Epigallocatechin gallate (EGCG) inhibits lipopolysaccharide‐induced inflammation in RAW 264.7 macrophage cells via modulating nuclear factor kappa‐light‐chain enhancer of activated B cells (NF‐κB) signaling pathway
  8. 11988
    “…Methods: We performed cardiac gene expression, whole genome sequencing (WGS), and cardiac function analysis in 40 strains of BXD recombinant inbred mice derived from C57BL/6J (B6) and DBA/2J (D2) strains. …”
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    Expression Levels of the Tnni3k Gene in the Heart Are Highly Associated with Cardiac and Glucose Metabolism-Related Phenotypes and Functional Pathways
  9. 11989
    “…Conserved motif and gene structure analyses showed that members of the same subfamily shared identical conserved motifs and gene structures, and probably have similar biological functions. Analysis of cis-acting elements revealed that CmACL promoter sequences contained regulatory elements related to light, stress, phytohormones, and growth and development, indicating that CmACL genes may be involved in melon growth and stress responses. …”
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    Identification of CmACL genes in melon and analysis of their potential functions in fruit sugar and acid accumulation
  10. 11990
    “…Through a previous structure-function analysis, it was determined that nucleolar stress induction is highly sensitive to modifications at the 4-position of the 1,2-diaminocyclohexane (DACH) ring of oxaliplatin. …”
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    Comparison of click-capable oxaliplatin and cisplatin derivatives to better understand Pt(ii)-induced nucleolar stress
  11. 11991
    “…RESULTS: In this study, we presented a comprehensive biological function analysis of SARS-CoV-2 infection in a clonal human lung epithelial A549 cell, revealing dramatic changes in protein phosphorylation pathways in host cells. …”
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    Adaptive learning embedding features to improve the predictive performance of SARS-CoV-2 phosphorylation sites
  12. 11992
    “…Finally, structure–function analysis of SM‐102 revealed that small changes in the number of carbons can improve upon mRNA delivery in ALI human lung cells. …”
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    Optimization of ionizable lipids for aerosolizable mRNA lipid nanoparticles
  13. 11993
    “…RESULT: The discriminant function analysis (DFA) of the three biofluids was used to find significant metabolites between the cases and the control group collectively. …”
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    1H NMR Using Metabolic Study in Body Fluids for Diagnosis of Cryptococcal Meningitis in Adults
  14. 11994
    “…The aim of the current study was in silico design of a novel ASNase with predicted improved enzymatic properties using strategies encompassing sequence-function analysis of known ASNase mutants. Additionally, current study aimed to show that the new enzyme is active. …”
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    Expression and Biological Evaluation of an Engineered Recombinant L-asparaginase Designed by In Silico Method Based on Sequence of the Enzyme from Escherichia coli
  15. 11995
    “…With several Na(V) subtypes emerging as potential therapeutic targets, structure-function analysis of Na(V)-inhibiting spider toxins at such subtypes is warranted. …”
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    Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes
  16. 11996
    “…CONCLUSION: We have shown by site-directed mutagenesis and structure/function analysis that 17β-HSDcl dimerization involves the αE and αF helices of both subunits. …”
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    Dimerization and enzymatic activity of fungal 17β-hydroxysteroid dehydrogenase from the short-chain dehydrogenase/reductase superfamily
  17. 11997
    “…CONCLUSION: With structural genomics initiatives determining structures with little, if any, functional characterization, development of protein structure and function analysis tools are a necessary endeavor. We have developed a useful application towards a solution to this problem using common structural and sequence based analysis tools. …”
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    Identification of similar regions of protein structures using integrated sequence and structure analysis tools
  18. 11998
    “…We present a structure-function analysis of the different DmKal-1 domains, including a predicted heparan-sulfate binding site. …”
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    Functional dissection of the Drosophila Kallmann's syndrome protein DmKal-1
  19. 11999
    “…The neurocognitive phenotype was measured as a quantitative trait, the Turner Syndrome Cognitive Summary (TSCS) score, derived from discriminant function analysis. Genetic analysis included karyotyping, X inactivation studies, fluorescent in situ hybridization, microsatellite marker genotyping, and array comparative genomic hybridization. …”
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    A Turner syndrome neurocognitive phenotype maps to Xp22.3
  20. 12000
    “…In particular, we identify 15 consecutive positions in the middle of the S5-P linker (583–597) where side chain modification has marked impact on channel function. Analysis of the degrees of mutation-induced perturbation in channel function along 583–597 reveals an α-helical periodicity. …”
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    Structural and Functional Role of the Extracellular S5-P Linker in the HERG Potassium Channel
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