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Análisis funcional
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Climatic variables influence annual P. montezumae growth
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12561“…METHODS: qRT‐PCR was used for circWHSC1 level evaluation; Kaplan‐Meier was used for survival analysis; bioinformatics, dual‐luciferase activity, and RNA pull‐down were used for evaluating competing endogenous RNA (ceRNA) network; cell viability, colony formation, apoptosis, migration, and invasion were used for cell function analysis; function gain and loss with rescue experiments were used for exploring mechanism of circWHSC1 in NSCLC development. …”
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12562“…Insulin-peak-time during the OGTT was recorded to reflect β-cell function. Analysis of covariance with baseline values as covariates was used to examine the effects of the intervention. …”
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12563por An, Yang, Wang, Yuanlin, Xu, Guoyong, Liao, Yinan, Huang, Ge, Jin, Xin, Xie, Chengxin, Li, Qinglong, Yin, Dong“…In addition, in molecular function analysis, DEGs are mainly enriched in the process of protein binding. …”
Publicado 2021
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12564por Abudhaise, Hamid, Taanman, Jan-Willem, DeMuylder, Peter, Fuller, Barry, Davidson, Brian R.“…This study aimed to examine the feasibility of mitochondrial function analysis during end-ischaemic HMP, assess potential mitochondrial viability biomarkers, and record oxygenation kinetics. …”
Publicado 2021
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12565por Wu, Fan, Sun, Guoqiang, Zheng, Wubin, Tang, Weiwei, Cheng, Ye, Wu, LiangLiang, Li, Xiao, Tao, Jing, Ma, Shijie, Cao, Hongyong“…Cell viability, migration, invasion, and other indicators were used for cell function analysis. Knockdown and overexpression techniques were used to explore the mechanism of circCORO1C in the occurrence and development of HCC by RNA sequencing, qRT‐PCR, western blot, and other methods. …”
Publicado 2021
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12566por Huang, Kuan-Ying A., Zhou, Daming, Tan, Tiong Kit, Chen, Charles, Duyvesteyn, Helen M. E., Zhao, Yuguang, Ginn, Helen M., Qin, Ling, Rijal, Pramila, Schimanski, Lisa, Donat, Robert, Harding, Adam, Gilbert-Jaramillo, Javier, James, William, Tree, Julia A., Buttigieg, Karen, Carroll, Miles, Charlton, Sue, Lien, Chia-En, Lin, Meei-Yun, Chen, Cheng-Pin, Cheng, Shu-Hsing, Chen, Xiaorui, Lin, Tzou-Yien, Fry, Elizabeth E., Ren, Jingshan, Ma, Che, Townsend, Alain R., Stuart, David I.“…However, the structure-function analysis of potent human anti-RBD monoclonal antibodies and its links to the formulation of antibody cocktails remains largely elusive. …”
Publicado 2022
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12567“…They were fed ad libitum before mating, throughout gestation and lactation, and next generations were weaned to the maternal diet. Reproductive function analysis (which include; gestation and pubertal hormonal profiling, onset of puberty, oestrus cyclicity, sexual response) and morphometric analysis of the ovarian structure were carried out to assess associated consequences. …”
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12568por Fang, Xiao, Duan, Shu-Fang, Hu, Zhi-Yuan, Wang, Jun-Jie, Qiu, Le, Wang, Fei, Chen, Xu-Lin“…RESULTS: Four hundred and twenty-nine differentially expressed genes (DEGs) and seven hub genes between sepsis patients and healthy controls were identified. GO function analysis of DEGs and hub genes indicated that the DEGs and hub genes were mainly enriched in neutrophil activation. …”
Publicado 2022
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12569“…Echo-based left ventricle fluid-structure interaction models were constructed to perform ventricle function analysis and investigate impact of pacemaker location on cardiac outcome. …”
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12570“…Pearson’s correlation analysis was used to evaluate the correlation between FRGs and the tumor mutational burden, microsatellite instability, tumor-infiltrating immunity, cellular checkpoint control, and drug sensitivity in LUAD. A loss-of-function analysis was performed to verify the function of CISD1 in LUAD progression. …”
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12571por Chen, Yong, Wang, Zi-Long, Yeo, Michele, Zhang, Qiao-Juan, López-Romero, Ana E., Ding, Hui-Ping, Zhang, Xin, Zeng, Qian, Morales-Lázaro, Sara L., Moore, Carlene, Jin, Ying-Ai, Yang, Huang-He, Morstein, Johannes, Bortsov, Andrey, Krawczyk, Marcin, Lammert, Frank, Abdelmalek, Manal, Diehl, Anna Mae, Milkiewicz, Piotr, Kremer, Andreas E., Zhang, Jennifer Y., Nackley, Andrea, Reeves, Tony E., Ko, Mei-Chuan, Ji, Ru-Rong, Rosenbaum, Tamara, Liedtke, Wolfgang“…Three-dimensional structural modeling, site-directed mutagenesis, and channel function analysis suggested a TRPV4 C-terminal motif for LPC binding and channel activation. …”
Publicado 2021
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12572“…Importantly, through loss-of-function analysis, we found that endogenous miR-10 and miR-958 target fu and smo, respectively, whereas deletion of the other five miRNAs leads to altered expression of Hh signaling components, suggesting that these seven newly discovered miRNAs regulate Hh signaling in vivo. …”
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12573por Tao, Dan, Wang, Ying, Zhang, Xin, Wang, Can, Yang, Dingyi, Chen, Jing, Long, Yanyan, Jiang, Yong, Zhou, Xian, Zhang, Ningning“…ROC curves and nomogram indicated that the risk score had good accuracy for determining BC patient survival. Biological function analysis showed that DEGs in high- and low-risk groups had a high enrichment in immune-related biological processes and signaling pathways. …”
Publicado 2022
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12574“…Bioinformatic analysis showed that these two genes and their interacting genes are enriched in the regulation of multiple immune pathways associated with SLE, including cytokine signaling and immune cell activation or function. Analysis of the synergistic regulation of these two genes suggests that abnormalities in the type I interferon pathway caused by genetic variants may contribute to the pathogenesis of SLE. …”
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12575por Milenkovic, Dragan, Kang, Jiye, Wang, Ziwei, Cremonini, Eleonora, Vauzour, David, Oteiza, Patricia“…The PCA and heatmap analysis revealed opposite expression of genes obtained following EC supplementation when compared to the gene expression profile obtained after consumption of the HFD. Functionality analysis revealed that the differentially expressed gene regulate processes involved in neurofunction, inflammation, cell-cell adhesion, and cell signaling. …”
Publicado 2022
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12576por Krgovic, Danijela, Gorenjak, Mario, Rihar, Nika, Opalic, Iva, Stangler Herodez, Spela, Gregoric Kumperscak, Hojka, Dovc, Peter, Kokalj Vokac, Nadja“…The diagnostic yield was further increased by 2.7% by the analysis of ultrarare or “single event” variants in all NDD-associated genes. Protein function analysis established that genes in which variants of unknown significance (VUS) were detected were predominantly the cause of intellectual disability (ID), and in most cases, features of ASD as well. …”
Publicado 2022
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12577por Abbariki, Faezeh, Roy, Marc‐Antoine, Labrecque, Lawrence, Drapeau, Audrey, Imhoff, Sarah, Smirl, Jonathan D., Brassard, Patrice“…We previously reported subtle dynamic cerebral autoregulation (dCA) alterations following 6 weeks of high‐intensity interval training (HIIT) to exhaustion using transfer function analysis (TFA) on forced mean arterial pressure (MAP) oscillations in young endurance‐trained men. …”
Publicado 2022
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12578por Wu, Donglin, Wang, Chunjie, Simujide, Huasai, Liu, Bo, Chen, Zhimeng, Zhao, Pengfei, Huangfu, Mingke, Liu, Jiale, Gao, Xin, Wu, Yi, Li, Xiaorui, Chen, Hao, Chen, Aorigele“…The microbiota was characterized using 16S rRNA sequencing of the V3–V4 hypervariable region, alpha diversity and beta diversity analyses (principal coordinate analysis, PCoA), cladogram of the linear discriminant analysis effect size (LEfSe) analysis, and microbiota function analysis. Levels of the reproductive hormones, except gonadotropin-releasing hormone (p > 0.05), shifted among D0, D9, and D12 (p < 0.05). …”
Publicado 2022
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12579por Yi, Xin, Chen, Yunong, Cai, Hongyan, Wang, Jiajia, Zhang, Youyu, Zhu, ZhiQin, Lin, Mao, Qin, Yingxue, Jiang, XingLong, Xu, Xiaojin“…Also, sequence alignment analysis, homology analysis and protein secondary structure function analysis showed that tatA, tatB, and tatC were highly conservative, indicating their biological significance. …”
Publicado 2022
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12580por Semelka, Charles T., DeWitt, Michael E., Blevins, Maria W., Holbrook, Beth C., Sanders, John W., Alexander-Miller, Martha A.“…Statistical analysis used antibody titers in linear mixed-effects linear regression with clinical predictors including, age, sex, prior infection status, and clinical frailty scale (CFS) score. T cell function analysis used clinical predictors and cellular phenotype variables in linear regression models. …”
Publicado 2022
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