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  1. 12661
    “…We found m(6)A methyltransferase METTL3 was significantly down-regulated in the RSA group. Through gene function analysis, RT-qPCR, MeRIP–qPCR validation experiment, knockdown, and overexpression of METTL3 in the HTR-8 cell line, ZBTB4 was selected as one target of METTL3. …”
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    METTL3-Mediated m(6)A RNA Methylation of ZBTB4 Interferes With Trophoblast Invasion and Maybe Involved in RSA
  2. 12662
    “…RESULTS: Biological function analysis showed that methylation of ARL4C and changes in immune cell infiltration and targeted drug sensitivity caused by altered ARL4C expression affected the prognosis of ccRCC. …”
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    ARL4C Regulates the Progression of Clear Cell Renal Cell Carcinoma by Affecting the Wnt/β-Catenin Signaling Pathway
  3. 12663
    “…The present study identified the antibacterial domain of omCK11. Structure-function analysis of various fish CCL27/28 proteins identified a novel antibacterial peptide (lcCCL28-25) from Larimichthys crocea CCL28 that exhibited broad-spectrum and the most acceptable bactericidal activity in vitro, as well as a protective effect in a Staphylococcus aureus infection mouse model. …”
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    LcCCL28-25, Derived from Piscine Chemokine, Exhibits Antimicrobial Activity against Gram-Negative and Gram-Positive Bacteria In Vitro and In Vivo
  4. 12664
    “…Cytosscape 3.7.2 software was used to construct CEP-common targets-signaling pathways-COVID-19 network, module function analysis, gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG). …”
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    The common regulatory pathway of COVID-19 and multiple inflammatory diseases and the molecular mechanism of cepharanthine in the treatment of COVID-19
  5. 12665
    “…Genetic and Epigenetic Alterations analysis were further conducted to explore the potential effect of AMIGO2 in PCa and examined by biological function analysis and in vitro experiments. RESULTS: AMIGO2 was associated with poor RFS (P<0.05) and differentially expressed (P<0.05) in multiple cancer type, especially in PCa. …”
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    Integrated analysis reveals prognostic value and progression-related role of AMIGO2 in prostate cancer
  6. 12666
    “…Then CIBERSORT algorithm was used to conduct Spearman correlation analysis, immune regulatory factor analysis and TIDE immune system function analysis for gene expression level and immune cell content. …”
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    Selective poly adenylation predicts the efficacy of immunotherapy in patients with lung adenocarcinoma by multiple omics research
  7. 12667
    “…GO, KEGG, and GSEA function analysis identified immune- and autophagy-related pathways. …”
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    Combining autophagy and immune characterizations to predict prognosis and therapeutic response in lung adenocarcinoma
  8. 12668
    “…There are 245 lncRNAs, 126 miRNAs, and 1980 mRNAs that are expressed differently in liver tumour tissues than in noncancerous cells. Function analysis showed that mRNAs in ceRNA network were significantly enriched in G1/S transition of mototiv cell cycle, positive regulation of cell cycle process, hepatocellular carcinoma, and cancer related pathways. …”
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    Comprehensive analysis of lncRNA-mediated ceRNA networkfor hepatocellular carcinoma
  9. 12669
    “…The expression profiles and function analysis of these DEGs were provided to expand our understanding of the complex molecular mechanism in pollen and sterility development in B. napus.…”
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    Global transcriptome analysis reveals potential genes associated with genic male sterility of rapeseed (Brassica napus L.)
  10. 12670
    “…In addition, 16S rRNA gene sequencing analysis combined with intestinal barrier function analysis revealed that the DHXSD significantly ameliorated ANIT-induced gut microbiota dysbiosis. …”
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    Transcriptome and Gut Microbiota Profiling Analysis of ANIT-Induced Cholestasis and the Effects of Da-Huang-Xiao-Shi Decoction Intervention
  11. 12671
    “…CA was assessed using transfer function analysis to calculate coherence, gain, and phase in the very-low-frequency (VLF; 0.020–0.070 Hz) and low-frequency bands (LF; 0.07–0.20 Hz). cBRS was calculated using the sequence method. …”
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    Acute beetroot juice consumption does not alter cerebral autoregulation or cardiovagal baroreflex sensitivity during lower-body negative pressure in healthy adults
  12. 12672
    “…The 4 calls significantly differed in both frequency and temporal parameters and can be clearly distinguished by discriminant function analysis. Minimum frequency of fundamental frequency (F(0min)) and duration of syllable (T) contributed the most to acoustic divergence between calls. …”
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    A small vocal repertoire during the breeding season expresses complex behavioral motivations and individual signature in the common coot
  13. 12673
    “…KEGG and GO based function analysis to differential lncRNA also shown the enrichment of immune response. …”
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    (5R)-5-Hydroxytriptolide (LLDT-8) induces substantial epigenetic mediated immune response network changes in fibroblast-like synoviocytes from rheumatoid arthritis patients
  14. 12674
    “…Patients were dichotomised into good adherers and poor adherers, categories that were then used as the variable in a predictive function analysis of the CQR5 in order to determine the accuracy of the classification at the end of the study period in comparison with the MPR. …”
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    Predictive validity of the 5-item Compliance Questionnaire for Rheumatology (CQR5) in detecting poor adherence of patients with rheumatoid arthritis to biological medication
  15. 12675
    “…We conducted gain-of-function analysis of microRNAs and their effects on cisplatin resistance, and we searched target genes comprehensively using Next Generation mRNA sequences. …”
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    EHHADH contributes to cisplatin resistance through regulation by tumor-suppressive microRNAs in bladder cancer
  16. 12676
    “…Differential test function analysis, however, supported that the 16 underfitting items did not represent a threat to the measurement system. …”
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    Measuring self-reported ability to perform activities of daily living: a Rasch analysis
  17. 12677
    “…RNA-seq analysis of the corresponding samples indicated that most of the genes in the above terms were upregulated in TYO fish. Moreover, gene function analysis revealed that the two genes involved in energy metabolism displayed antiviral effects. …”
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    Genome-wide DNA methylation reveals potential epigenetic mechanism of age-dependent viral susceptibility in grass carp
  18. 12678
    “…METHODS: The mitochondrial function analysis was performed using an extracellular flux assay, which simultaneously monitored both oxygen consumption rate (OCR) and extracellular acidification rate (ECAR). …”
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    Mitochondrial toxicants in Xian-Ling-Gu-Bao induce liver injury by regulating the PI3K/mTOR signaling pathway: an in vitro study
  19. 12679
    “…The density of vents within the limits of the volcanic field (estimated by using spatial point density analysis) and found to vary from 0 to a maximum of 2 volcanoes per square ki­lometer. Kernel density function analysis re­vealed that the highest concentrations of vol­canoes occur NW of Xalapa between Acajete and Las Vigas de Ramirez (La Joya group), and N of Coacoatzintla, while lesser concentra­tions occur around Pacho Viejo and to the N of Ayahualulco. …”
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    El Campo Volcánico Xalapa: una revisión y análisis
  20. 12680
    “…RNA interference (RNAi) has been used in gene function analysis and the development of insect control methods. …”
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    Simultaneous silencing of juvenile hormone metabolism genes through RNAi interrupts metamorphosis in the cotton boll weevil
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