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  1. 427981
    “…Our data indicate a novel link between cathepsin activity and metabolic reprogramming in macrophages, demonstrated by a profound impact on autophagy and fatty acid metabolism, which facilitates a pro-inflammatory micromilieu generally associated with enhanced tumor elimination. …”
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    Cathepsin Inhibition Modulates Metabolism and Polarization of Tumor-Associated Macrophages
  2. 427982
    “…The binding sites of common transcription factors such as MYB, WRKY, and ABRE that control target genes in abiotic and biotic stresses were generally distributed in promoter sites of ethylene biosynthesis genes of A. thaliana. …”
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    Insights into the genes involved in the ethylene biosynthesis pathway in Arabidopsis thaliana and Oryza sativa
  3. 427983
    “…Therefore, in this study, we discriminated different ambient PM(2.5) and estimated the effects on a global scale. Using the generalized linear mixed-effects model (GLMM) with a random-effects model, we found that biomass PM(2.5) was associated with an 8.9% (95% confidence interval [CI] 4.1–13.9%) increased risk of under-five deaths, while dust PM(2.5) was marginally associated with 9.5% of under-five deaths. …”
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    Impacts of discriminated PM(2.5) on global under-five and maternal mortality
  4. 427984
    “…The phase II algorithm trained on images labeled by the phase I algorithm achieved an AUC of 0.91 testing against a TB dataset obtained from Shenzhen, China and Montgomery County, USA. The algorithm generalized well to radiographs obtained from a tertiary care hospital, achieving an AUC of 0.87; TBNet’s sensitivity, specificity, positive predictive value, and negative predictive value were 85%, 76%, 0.64, and 0.9, respectively. …”
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    Refining dataset curation methods for deep learning-based automated tuberculosis screening
  5. 427985
    “…However, for some traits genomic prediction was only feasible in across-ecotype analysis. Our results generally underpin the potential of genomic selection to enhance health and productivity across-ecotypes. …”
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    Integrating Genetic and Genomic Analyses of Combined Health Data Across Ecotypes to Improve Disease Resistance in Indigenous African Chickens
  6. 427986
    “…Blood samples were collected from two bulls nearest to the median BW on arrival in each pen (n = 96) and fecal samples were collected from cattle in block 3 (n = 96). The generalized complete block design consisted of 12 pen replications per treatment with pen as the experimental unit. …”
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    Effects of Bacillus subtilis PB6 and/or chromium propionate supplementation on serum chemistry, complete blood count, and fecal Salmonella spp. count in high-risk cattle during the feedlot receiving and finishing periods(,)
  7. 427987
    “…Small companies, which account for 68% (2888/4249) of all firms in the present study, generally have fewer resources to remain current with the continuously evolving health and safety at work regulations; moreover, these firms tend to be less compliant with health and safety at work regulations since they are less likely to be inspected by occupational vigilance services. …”
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    The Italian National Surveillance System for Occupational Injuries: Conceptual Framework and Fatal Outcomes, 2002–2016
  8. 427988
    “…CONCLUSIONS: Both treatments were generally well tolerated, although serious AE rates were higher with the combination. …”
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    A randomized phase 2 trial of pembrolizumab versus pembrolizumab and acalabrutinib in patients with platinum‐resistant metastatic urothelial cancer
  9. 427989
    “…Together, these data identify a novel mechanism for viral antagonism of innate immune signaling which relies on sequestration of the NF-κB subunit p65 to a biomolecular condensate—a mechanism conserved across the Orthopneumovirus genus and not host-cell specific. More generally, they provide additional evidence that RNA virus IBs are important immunomodulatory complexes within infected cells. …”
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    Respiratory Syncytial Virus Sequesters NF-κB Subunit p65 to Cytoplasmic Inclusion Bodies To Inhibit Innate Immune Signaling
  10. 427990
    “…Various anti-PMOP drugs have been developed to reduce the burden of PMOP; generally, these drugs are efficacious, but with some adverse side effects. …”
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    The Interventional Effects of Tubson-2 Decoction on Ovariectomized Rats as Determined by a Combination of Network Pharmacology and Metabolomics
  11. 427991
    por Xu, Tao, Zhu, Guangjin, Han, Shaomei
    Publicado 2020
    “…The aim of this study was to determine the prevalence of MetS and associated lifestyle factors in Chinese adults 18 to 80 years of age, using multi-level generalized estimation equation (GEE). The participants came from a large-scale cross-sectional population survey. …”
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    Prevalence of and lifestyle factors associated with metabolic syndrome determined using multi-level models in Chinese adults from a cross-sectional survey
  12. 427992
    “…Mammalian protein production platforms that incorporate protein packaging eukaryotic cell lines are superior to prokaryotic bacterial expression systems and are likely to have a significant impact on the development of new humanized biological growth factor therapies for treating focal cartilage defects and more generally for the treatment of degenerative joint diseases such as OA, especially when injected directly into the joint.…”
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    Over-Production of Therapeutic Growth Factors for Articular Cartilage Regeneration by Protein Production Platforms and Protein Packaging Cell Lines
  13. 427993
    “…Typically, TNTs exhibit increased formation under conditions of cellular stress and are more prominent in cancer cells, where they are generally thought to be pro-metastatic and to provide growth and survival advantages. …”
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    Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells
  14. 427994
    “…The risk of implant failure was analyzed with a simple binary logistic regression model with generalized equation equations (GEE) models, obtaining unadjusted odds ratios (OR). …”
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    Factors Affecting Implant Failure and Marginal Bone Loss of Implants Placed by Post-Graduate Students: A 1-Year Prospective Cohort Study
  15. 427995
    por Nath, Abhigyan, Leier, André
    Publicado 2020
    “…Models trained on K-means sampled datasets generally show a significantly improved performance compared to those trained on random selections—with RF seemingly benefiting most in our particular setting. …”
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    Improved cytokine–receptor interaction prediction by exploiting the negative sample space
  16. 427996
    por Wang, Xianzong, Yan, Junli
    Publicado 2020
    “…The results showed that both duplicates were subject to strong positive selection; however, for an extant species, generally at most one copy was under positive selection. …”
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    Directional divergence of Ep300 duplicates in teleosts and its implications
  17. 427997
    “…Some medical schools have incorporated art into their curricula to increase empathy generally, yet few programs use art to address racial disparities in medicine specifically. …”
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    Toward an Anti-Racist Curriculum: Incorporating Art into Medical Education to Improve Empathy and Structural Competency
  18. 427998
    “…CAT and mMRC scores were analyzed with generalized linear regression models using IPTW propensity scores. …”
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    Symptom Burden and GOLD Classification in Medicare Advantage Patients with COPD Initiating Umeclidinium/Vilanterol or Fluticasone Propionate/Salmeterol Therapy
  19. 427999
    “…Diets that included Leucaena forage legumes had generally higher crude protein contents and higher DMI. …”
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    Nutritional Quality, Voluntary Intake and Enteric Methane Emissions of Diets Based on Novel Cayman Grass and Its Associations With Two Leucaena Shrub Legumes
  20. 428000
    por Baek, Bin, Lee, Hyunju
    Publicado 2020
    “…When support vector machines, random forest, logistic regression, and L2 regularized logistic regression were used as prediction models, logistic regression analysis generally revealed the best performance for both disease-free survival (DFS) and overall survival (OS) (accuracy [ACC] = 0.762 and area under the curve [AUC] = 0.795 for DFS; ACC = 0.776 and AUC = 0.769 for OS). …”
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    Prediction of survival and recurrence in patients with pancreatic cancer by integrating multi-omics data
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