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  1. 432061
    “…CONCLUSIONS: Avelumab generally was found to be well tolerated and to have a manageable safety profile. …”
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    Safety profile of avelumab in patients with advanced solid tumors: A pooled analysis of data from the phase 1 JAVELIN solid tumor and phase 2 JAVELIN Merkel 200 clinical trials
  2. 432062
    “…Herein we demonstrate the generality of zerovalent, group 10 m-terphenyl isocyanide complexes to form reverse-dative σ-interactions to Tl(i) and Ag(i) centers. …”
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    Metal-only Lewis pairs between group 10 metals and Tl(i) or Ag(i): insights into the electronic consequences of Z-type ligand binding
  3. 432063
    “…Moreover, there was no significant difference (P<0.05) in the percentage conformity of the package inserts collected from each of the three Partner States as compared to the average from studied medicines. A generally good conformity was observed among medicines manufactured by European based manufacturers as compared to those based in Asia and EAC Partner States. …”
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    Conformity of package inserts information to regulatory requirements among selected branded and generic medicinal products circulating on the East African market
  4. 432064
    “…This study assessed adoption and adherence to healthy lifestyle behaviours and health outcomes 3 years after a lifestyle modification intervention, using generalized estimating equation models to account for within-participant correlation over time. …”
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    Health outcomes and adherence to a healthy lifestyle after a multimodal intervention in people with multiple sclerosis: Three year follow-up
  5. 432065
    “…Lipid-lowering drugs, although generally efficacious, may sometimes cause adverse events. …”
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    LDL-cholesterol lowering effect of a new dietary supplement: an open label, controlled, randomized, cross-over clinical trial in patients with mild-to-moderate hypercholesterolemia
  6. 432066
    “…RESULTS: Overall, participants had a mean age of 55 years (SD 8) and completed 16 years of school (SD 2). Participants generally agreed that learning to use Life in a Day was easy (83%, 33/40) and would prefer to log activities using Life in a Day over paper-and-pencil diary (73%, 29/40). …”
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    Acceptability of a Mobile Phone App for Measuring Time Use in Breast Cancer Survivors (Life in a Day): Mixed-Methods Study
  7. 432067
    Publicado 2018
    “…BACKGROUND AND OBJECTIVE: Malignant pleural effusion (PE) was generally defined as pleural effusion containing tumors with poor prognosis. …”
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    局限期小细胞肺癌合并胸水临床特点及预后因素分析
  8. 432068
    “…We next tested if these brain properties could be generalized to predict time to clinical progression in a subgroup of 26 individuals from the Alzheimer’s Disease Neuroimaging Initiative, who eventually converted either to mild cognitive impairment or to Alzheimer’s dementia. …”
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    Brain properties predict proximity to symptom onset in sporadic Alzheimer’s disease
  9. 432069
    “…Maximum viral loads achieved in macaques by subcutaneous inoculation of DENV are generally much lower than those observed in naturally dengue virus-infected humans. …”
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    Improvement of the Dengue Virus (DENV) Nonhuman Primate Model via a Reverse Translational Approach Based on Dengue Vaccine Clinical Efficacy Data against DENV-2 and -4
  10. 432070
    “…Associations of age group and gender with ART initiation, loss to follow‐up and all‐cause death, were analysed using Cox proportional hazards regression and with adherence, using generalized estimating equations (GEE) with the Poisson distribution. …”
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    Equity of child and adolescent treatment, continuity of care and mortality, according to age and gender among enrollees in a large HIV programme in Tanzania
  11. 432071
    “…Cumulative incidences of all‐cause mortality and loss to follow‐up (LTFU), adherence measured using medication possession ratios (MPRs), CD4 count slope, and virological suppression were analysed using multivariable Cox, competing‐risks regression, generalized estimating equations and mixed‐effects models over five years of ART. …”
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    The effectiveness and cost‐effectiveness of community‐based support for adolescents receiving antiretroviral treatment: an operational research study in South Africa
  12. 432072
    “…Thus, we have no evidence that 3-OHB generally influences the biology of breast cancer cells in vitro. …”
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    Beta-hydroxybutyrate (3-OHB) can influence the energetic phenotype of breast cancer cells, but does not impact their proliferation and the response to chemotherapy or radiation
  13. 432073
    “…The risk of bias of these trials was generally unclear or high. Meta-analysis indicated that Biqi capsule had better effects on C-reactive protein [standardized mean difference (SMD), −7.05; 95% CI -(10.77–3.33)] and tender joint count [SMD, −3.02; 95% CI, -(3.81–2.22)] and fewer adverse effects (AEs) than MTX [relative risk (RR), 0.19; 95% CI, 0.08–0.43]. …”
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    Systematic review and meta-analysis of the efficacy and safety of Biqi capsule in rheumatoid arthritis patients
  14. 432074
    “…Two-level hierarchical generalized linear models, with patients aggregated at the physician level, were used to assess the association between treatment intensification and achieving HbA1C quality performance measures. …”
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    Assessment of the relationship between diabetes treatment intensification and quality measure performance using electronic medical records
  15. 432075
    “…To improve delivery of the interventions, the experiments were repeated in Group 2 with limited suctioning/SCMV, which generally increased PAs in (BAL). In Group 2, tPA was ineffective, but scuPA (4 or 8 mg) improved physiologic outcomes (p < 0.01) and plateau pressures remained lower at 48 h. …”
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    Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator
  16. 432076
    “…A consistent sustained increase of expression for most genes in response to Scl-Ab was observed from day 8 through day 85 at the times of maximal bone formation on both Ct surfaces; however, at day 183, this increase was reversed, with expression of these genes generally returning to control values or decreasing compared to vehicle. …”
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    Differential time-dependent transcriptional changes in the osteoblast lineage in cortical bone associated with sclerostin antibody treatment in ovariectomized rats
  17. 432077
    “…Using Hierarchical Generalized Linear Models, we also evaluated provider-level and patient-level factors associated with lung cancer screening orders among 970 primary care providers and 12,801 eligible patients according to USPSTF guidelines between January 1st, 2014 and December 31st, 2016. …”
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    New recommendation and coverage of low-dose computed tomography for lung cancer screening: uptake has increased but is still low
  18. 432078
    “…The primary reasons for premature discontinuation of CPT were CD4 greater than 350 cells/mm(3), severe sulfa allergy and first trimester of pregnancy. Generally, the use of cotrimoxazole prophylaxis was consistent with the WHO guideline for indication to start (n = 519, 93.3%) and dose (n = 552, 99.28%), despite the presence of contraindication in 6.65% patients. …”
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    Appropriateness of Cotrimoxazole Prophylactic Therapy Among HIV/AIDS Patients in Public Hospitals in Eastern Ethiopia: A Retrospective Evaluation of Clinical Practice
  19. 432079
    “…BACKGROUND: Randomized clinical trials are the gold standard for evaluating healthcare interventions and, more generally, add to the medical knowledge related to the treatment, diagnosis and prevention of diseases and conditions. …”
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    An initiative using informatics to facilitate clinical research planning and recruitment in the VA health care system
  20. 432080
    “…A number of socioeconomic and medical data as well as SF-12-scores were entered into a generalized linear mixed model to identify variables associated with excessive polypharmacy (taking ≥10 substances daily). …”
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    Polypharmacy in older patients with chronic diseases: a cross-sectional analysis of factors associated with excessive polypharmacy
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