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  1. 434181
    “…In orthogonal sequencing, we found high concordance between targeted panel and whole exome sequencing in both variant detection and variant allele frequency estimation (specificity = 95.5%, VAF correlation, r = 0.949), Copy number remained generally stable, despite resolution limitations posed by low tumor fraction. …”
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    Modeling clonal structure over narrow time frames via circulating tumor DNA in metastatic breast cancer
  2. 434182
    por Hoover, Coeli M., Smith, James E.
    Publicado 2021
    “…RESULTS: Regional average aboveground live tree carbon stocks (represented on a per area basis) are generally between 40 and 75 tC/ha but range from 12.8 tC/ha in the Great Plains to 130 tC/ha in the Pacific Northwest West (west-side of Cascades). …”
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    Current aboveground live tree carbon stocks and annual net change in forests of conterminous United States
  3. 434183
    “…The control group was selected among women, aged 20–40 years, who participated in Tehran Lipid and Glucose cohort Study (TLGS). Generalized additive models (GAMs) were used to identify the optimal cut-off points for various age categories. …”
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    Age-specific cut-off levels of anti-Müllerian hormone can be used as diagnostic markers for polycystic ovary syndrome
  4. 434184
    “…Several studies report that the L1 retrotransposon is highly active in many cancers. L1 activity is generally determined by assaying L1ORF1p because of its high expression and availability of the antibody. …”
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    Robust expression of LINE-1 retrotransposon encoded proteins in oral squamous cell carcinoma
  5. 434185
    “…A blood sample was collected by finger prick and malaria was diagnosed using rapid diagnostic test (RDT). Generalized estimating equation (GEE) Poisson model that accounts for repeated measure of malaria episodes was applied to assess the risk factors of P. vivax episode. …”
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    Older children are at increased risk of Plasmodium vivax in south-central Ethiopia: a cohort study
  6. 434186
    “…CONCLUSIONS: Neoadjuvant nivolumab was generally safe and induced pathologic regressions in HPV-positive (23.5%) and HPV-negative (5.9%) tumors. …”
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    Neoadjuvant nivolumab for patients with resectable HPV-positive and HPV-negative squamous cell carcinomas of the head and neck in the CheckMate 358 trial
  7. 434187
    “…Limited daily activities included any difficulties with mobility (e.g., going outside), self-care (e.g., eating), and household activities (e.g., laundering). Generalized estimation equation models were used to examine whether previous falls and fear of falling independently predicted development of limited daily activities adjusting covariates. …”
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    Fear of falling is as important as multiple previous falls in terms of limiting daily activities: a longitudinal study
  8. 434188
    “…A total of 76,853 children born five years preceding the survey were included in the final analysis. A Generalized Linear Mixed Models (GLMM) were fitted and an adjusted odds ratio (AOR) with a 95% Confidence Interval (CI) was computed to declare statistically significant determinants of adverse birth outcomes. …”
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    Determinants of adverse birth outcome in Sub-Saharan Africa: analysis of recent demographic and health surveys
  9. 434189
    “…Probabilistic sensitivity analyses (PSA) evaluated the uncertainty around the cost estimates. Generalized regression models were fitted to assess the effect of potential predictive factors on the time lost and the DW during illness. …”
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    Care-seeking behaviour and socio-economic burden associated with uncomplicated malaria in the Democratic Republic of Congo
  10. 434190
    “…METHODS: Using cost weights attributed to diagnostic codes in the NT Department of Health’s hospital admission data set (2008–2014), we calculated the mean (SD) total annual health service costs by dialysis model for 995 dialysis patients. Generalized linear modeling with bootstrapping tested the marginal cost differences between different explanatory variables to estimate ‘best casemix’/‘worst casemix’ cost scenarios. …”
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    Do remote dialysis services really cost more? An economic analysis of hospital and dialysis modality costs associated with dialysis services in urban, rural and remote settings
  11. 434191
    “…Total HIV-1 DNA in blood at baseline, 12, 24, 48, 96, 144 and 288 weeks after combined antiretroviral therapy (cART) initiation were quantified. Generalized estimating equations and logistic regression methods were used to derive and validate a predictive model of total HIV-1 DNA after 96 weeks of cART. …”
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    Therapeutic prediction of HIV-1 DNA decay: a multicenter longitudinal cohort study
  12. 434192
    “…CONCLUSIONS: Treatment with relugolix for 24 weeks was generally well tolerated and demonstrated similar pain reduction to leuprorelin in women with endometriosis. …”
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    Relugolix, an oral gonadotropin-releasing hormone (GnRH) receptor antagonist, in women with endometriosis-associated pain: phase 2 safety and efficacy 24-week results
  13. 434193
    “…Investigation in diverse contexts is necessary to confirm and generalize our results and to understand how to adapt the intervention for different settings. …”
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    Outcomes of a multicomponent safe surgery intervention in Tanzania’s Lake Zone: a prospective, longitudinal study
  14. 434194
    “…Because the electron beam characteristics of any single accelerator are unique and generally unknown, an appropriate model of an electron beam must be assumed before MC simulations can be run. …”
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    DeepBeam: a machine learning framework for tuning the primary electron beam of the PRIMO Monte Carlo software
  15. 434195
    por Zhu, Jingmin, Yan, Wenxin, zhu, Lin, Liu, Jue
    Publicado 2021
    “…We compared COVID-19 epidemic in BRICS countries and analyzed related factors by log-linear Generalized Additive Model (GAM) models. RESULTS: In BRICS countries, India had the highest totally of confirmed cases with 18.76 million, followed by Brazil (14.45 million), Russia (4.81 million), and South Africa (1.58 million), while China (0.10 million) had the lowest figure. …”
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    COVID-19 pandemic in BRICS countries and its association with socio-economic and demographic characteristics, health vulnerability, resources, and policy response
  16. 434196
    “…The implementation will be described using generalized estimating equation models. The persistence of PKI use will be represented using a Kaplan-Meier survival curve. …”
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    Optimizing Oral Targeted Anticancer Therapies Study for Patients With Solid Cancer: Protocol for a Randomized Controlled Medication Adherence Program Along With Systematic Collection and Modeling of Pharmacokinetic and Pharmacodynamic Data
  17. 434197
    “…However, the difference in mortality between 100 and 200 µg AI/bottle was minimal and large-scale testing using 100 µg AI/bottle with wild An. gambiae s.l. in 16 countries showed that this concentration was generally suitable, with a median mortality rate of 100% at 72 h. …”
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    Determination of the discriminating concentration of chlorfenapyr (pyrrole) and Anopheles gambiae sensu lato susceptibility testing in preparation for distribution of Interceptor® G2 insecticide-treated nets
  18. 434198
    “…CONCLUSIONS: Our findings from two complementary competing risk time-to-event models indicate that short rLTL may be a valuable predictor of the AD incidence in non-APOE ε4-carriers, on average 8 years before AD onset. More generally, the findings highlight the importance of accounting for competing risks, as well as the APOE status of participants in AD biomarker research. …”
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    Short leukocyte telomeres predict 25-year Alzheimer's disease incidence in non-APOE ε4-carriers
  19. 434199
    “…Studies of AChEIs suggested that patients with significant functional impairments had slight but significant improvements in cognition and that AChEIs were generally well tolerated. Studies of antidepressants did not show significant improvements in depressive symptoms. …”
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    Efficacy and safety of pharmacotherapy for Alzheimer’s disease and for behavioural and psychological symptoms of dementia in older patients with moderate and severe functional impairments: a systematic review of controlled trials
  20. 434200
    “…LIMITATIONS: Analyses were generally based on low-certainty evidence. Few studies reported outcomes in people with CKD without COVID-19 to calculate the excess risk attributable to COVID-19, and potential confounders were not adjusted for in most studies. …”
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    Incidence and Outcomes of COVID-19 in People With CKD: A Systematic Review and Meta-analysis
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