“…BACKGROUND: Although melanoma is generally regarded as an immunogenic cancer that will respond to immune checkpoint inhibitors (ICIs), melanomas with CCND1 amplification respond poorly to these therapies. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The compound P(5)W(30) showed the highest activity against the majority of the tested bacterial strains in comparison with the other tested POTs (P(2)W(15), P(2)W(17) and P(2)W(18)) that did not show inhibition zones for the Gram-negative bacteria, A. baumanii I73775, E. coli DSM 1077, E. coli I73194, K. pneumoniae I7092374, and P. aeruginosa C46281). Generally, the results evidenced that Gram-positive bacteria are more susceptible to the POTs tested. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In China, Chinese medicine injections (CMIs) have been generally combined with Western medicine (WM) to treat IPF, which are safe and effective. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The outcome was regressed against county-level measures for racial/ethnic composition, urbanicity, income, social vulnerability index, COVID-19 mortality, 2020 election results, and availability of nontraditional vaccination locations using generalized estimating equations. Across the US, 61.4% of eligible healthcare facilities and 76.0% of eligible pharmacies provided COVID-19 vaccinations as of May 2021. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…On a utilisé la définition de la COVID longue de l'Organisation mondiale de la santé (Octobre 2021) : « la survenue de symptômes généralement trois mois après une infection confirmée ou probable au SARS-CoV2, qui persistent au moins deux mois. » Le recueil des données socioéconomiques et cliniques a été fait à partir des dossiers des malades et celui des données sur la COVID longue par appel téléphonique. …”
Enlace del recurso
Enlace del recurso

“…Nous avons évalué le risque d'acquisition du SARS-CoV-2 selon l’âge et les liens familiaux, à partir des données de la cohorte française en population générale EPICOV. MÉTHODES: En novembre 2020, un échantillon aléatoire de 20 % des participants à EPICOV se sont vus proposer un auto-prélèvement sanguin pour tous les membres de leur foyer > 5 ans, en vue d'une sérologie (ELISA Euroimmun Anti-SARS-CoV-2 IgG). …”
Enlace del recurso
Enlace del recurso

“…This kind of poly-drug use, and more generally the growing importance of synthetic substances, highlights the urgent need to further develop forensic and toxicological resources if we are to better understand and respond rapidly to the increasingly complex drug problems.…”
Enlace del recurso
Enlace del recurso

“…Hazard quotient (HQ) values were < 1 except for Mn through dermal contact at all sites during partial and complete lockdown, similar to hazard index (HI), while Cr further showed high non-carcinogenic risks to children. Generally, children HI values were about 5–6 times higher than those of adults, suggesting a greater vulnerability of children to the health concerns caused by toxic elements in street dust. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…An initial evaluation suggests users generally view the Toolkit favorably in terms of adoption and implementation; however, they described cost and stakeholder buy-in as remaining challenges. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS AND RELEVANCE: Results of this randomized clinical trial demonstrate that both EP and IP remain the standard first-line chemotherapy options. Although AEs were generally manageable, grade 3 and 4 AEs were more common in the EP arm. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Combined with fragment ion intensity prediction, retention time prediction is used to generate spectral libraries for data-independent acquisition (DIA)-based mass spectrometry analysis. Generally, DIA methods identify peptides using specific spectrum libraries obtained from data-dependent acquisition (DDA) experiments. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Significant progress has been made in the study of toxicity mechanisms and detection methods of type Ⅱ RIPs, which primarily involve qualitative and quantitative analysis methods including immunological assays, mass spectrometry analysis methods, and toxin activity detection methods based on depurination and cytotoxicity. Immunoassays generally involve the specific recognition of antigens and antibodies, which is based on oligonucleotide molecular recognition elements called aptamers. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The extraction effect of water sample under neutral conditions was the best and the most stable, and under alkaline condition, the recovery of each substance was generally low. Finally, extraction time (7, 10, 15 min) was studied. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The strength of the existing chip substrate materials is generally below 60 MPa, and the material properties limit further advances in the miniaturization and integration of chromatographic chips. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Evidence for whether this results in poorer outcomes is conflicting and generally based on administrative or voluntary registry data. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…MAIN OUTCOMES AND MEASURES: The main outcome was the distribution of terminal digits and mean systolic BP (SBP) values obtained during 4 years of manual measurement vs 3 years of automated measurement, assessed using a generalized linear mixed regression model with a random intercept for clinic and adjusted for seasonal fluctuations and patient demographic and clinical characteristics. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Pooled FGM/C prevalence was estimated by random-effects meta-analysis using generalized linear mixed models (GLMMs). FGM/C prevalence with 95% confidence intervals (CIs), prediction intervals (PIs), and FGM/C type were presented separately by women aged 15 to 49 years and girls aged 0 to 14 years. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Due to eligibility criteria and procedures in our cohort, we can only generalize our model to athletes without major concomitant injuries who follow a similar treatment algorithm. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: In this cross-sectional study, demographic information, COVID-19-related questions, anxiety (Generalized Anxiety Disorder-7, GAD-7), depression (Patient Health Questionnaire-9, PHQ-9), insomnia (Insomnia Severity Index, ISI), stress (Perceived Stress Scale-10, PSS-10), and QOL (World Health Organization Quality of Life-brief version, WHOQOL-BREF) were collected. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Multivariate regression models adjusted by potential confounding factors, the violin plots, the generalized additive model and smooth curve fittings, receiver operating characteristic (ROC) curve, and Kaplan–Meier (K-M) curve analysis were applied to the research. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso