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  1. 2021
    “…The disease manifests severely, causing intellectual deficits and other neural abnormalities, hypercoagulability, uncontrolled self-injury, and gout. While allopurinol is used to alleviate gout, other symptoms are less understood, impeding treatment. …”
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    Red Blood Cells from Individuals with Lesch–Nyhan Syndrome: Multi-Omics Insights into a Novel S162N Mutation Causing Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency
  2. 2022
    “…CONCLUSION: The results indicate that diclofenac sodium has hepatotoxic, nephrotoxic, and visceral gout inducing potentials in White Leghorn birds, especially at higher dose.…”
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    Diclofenac-induced biochemical and histopathological changes in white leghorn birds (Gallus domesticus)
  3. 2023
    “…ABCG2, also known as BCRP, is a high-capacity urate exporter, the dysfunction of which raises gout/hyperuricemia risk. Generally, hyperuricemia has been classified into urate 'overproduction type' and/or 'underexcretion type' based solely on renal urate excretion, without considering an extra-renal pathway. …”
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    Decreased extra-renal urate excretion is a common cause of hyperuricemia
  4. 2024
    “…Discussion: In the first century, Pliny the Elder described in Natural Histories that a decoction of the root in water could be used to relieve stiffness in the joints, gout, and related conditions. By the 17th century, various herbalists were recommending cannabis root to treat inflammation, joint pain, gout, and other conditions. …”
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    Cannabis Roots: A Traditional Therapy with Future Potential for Treating Inflammation and Pain
  5. 2025
    “…INTRODUCTION: Colchicine is used for the treatment of gout, pseudo-gout, familial Mediterranean fever, and many other illnesses. …”
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    Transethosomal gels as carriers for the transdermal delivery of colchicine: statistical optimization, characterization, and ex vivo evaluation
  6. 2026
    “…A 48-year-old male with a history of medically treated tophaceous gout presented with left foot neuropathic pain and paresthesia, in the setting of a well-circumscribed soft tissue lesion of the second intermetatarsal space, suspected to be a Morton’s neuroma. …”
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    A Case of a Second Intermetatarsal Space Gouty Tophus with a Presentation Similar to a Morton’s Neuroma
  7. 2027
    “…Gout is a kind of joint disease characterized by the accumulation of monosodium urate (MSU) crystals in the joint and its surrounding tissue, causing persistent hyperuricemia. …”
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    Design, characterization and comparison of transdermal delivery of colchicine via borneol-chemically-modified and borneol-physically-modified ethosome
  8. 2028
    “…We applied Mendelian randomization analyses to investigate the potential causality between blood minerals (calcium, magnesium, iron, copper, and zinc) and osteoporosis (OP), gout, rheumatoid arthritis (RA), type 2 diabetes (T2D), Alzheimer’s disease (AD), bipolar disorder (BD), schizophrenia, Parkinson’s disease and major depressive disorder. …”
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    Mineral Nutrition and the Risk of Chronic Diseases: A Mendelian Randomization Study
  9. 2029
    “…It has been reported that Lactobacillus gasseri PA3 has an ability to absorb exogenous purines in the intestine to reduce a risk of gout and hyperuricemia. However, influences of this strain on gut microbiota and their metabolisms remain unclear. …”
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    Effect of Lactobacillus gasseri PA3 on gut microbiota in an in vitro colonic simulation
  10. 2030
    “…Evidence from clinical studies show that fire needle exerts therapeutic effects on gout arthritis, but no evidence-based medicine is available. …”
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    Efficacy and safety of fire-needle in the treatment of gouty arthritis: A protocol for systematic review and meta analysis
  11. 2031
    “…More attention should be paid to gout, proteinuria, CVD, serum phosphorus levels, and renal function in T2DM patients with SRCs.…”
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    The Relationship Between Simple Renal Cysts and Renal Function in Patients With Type 2 Diabetes
  12. 2032
    “…Hyperuricemia is the main cause of gout and involved in the occurrence of many other diseases such as hyperlipidemia and hypertension correlated with metabolic disorders. …”
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    Anti-Inflammatory and Anti-Hyperuricemic Effects of Chrysin on a High Fructose Corn Syrup-Induced Hyperuricemia Rat Model via the Amelioration of Urate Transporters and Inhibition of NLRP3 Inflammasome Signaling Pathway
  13. 2033
    “…Symptoms include hyperuricemia, gout, interstitial nephritis, renal cysts, and progressive renal damage that can lead to end-stage renal disease. …”
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    Autosomal dominant tubulointerstitial kidney disease with a novel heterozygous missense mutation in the uromodulin gene: A case report
  14. 2034
    “…BACKGROUND: In adults, gut dysbiosis may contribute to the pathogenesis of gout. However, the characteristics of gut microbiota in children with hyperuricemia (HUA) in the absence of clinical gout have not been explored. …”
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    Altered Gut Microbiota in Children With Hyperuricemia
  15. 2035
    “…This article reviews the synthesis and metabolism of UA, etiology of HUA, the relationship between HUA and kidney disease, the treatment of gout and gouty nephropathy (GN).…”
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    Excess Uric Acid Induces Gouty Nephropathy Through Crystal Formation: A Review of Recent Insights
  16. 2036
    “…The results of this study can serve as a reference for the prevention of preclinical gout as well as for functional food research.…”
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    Protective effects of corni fructus extract in mice with potassium oxonate–induced hyperuricemia
  17. 2037
    “…Case presentation: A 54-year-old man with a history of gout presented with a change in character and cognitive dysfunction. …”
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    Successful Treatment of Acute Uric Acid Nephropathy with Rasburicase in a Primary Central Nervous System Lymphoma Patient Showing a Dramatic Response to Methotrexate—Case Report
  18. 2038
    “…SIMPLE SUMMARY: Hyperuricemia is a major risk factor for gout. Inhibition of liver xanthine oxidase has been shown to reduce the uric acid level in blood. …”
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    Alleviation of Hyperuricemia by Strictinin in AML12 Mouse Hepatocytes Treated with Xanthine and in Mice Treated with Potassium Oxonate
  19. 2039
    “…The incidences of frozen shoulder (P < 0.001) and gout (P = 0.043) were higher during the COVID-19 pandemic than during the pre-COVID-19 period. …”
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    Changes in the mean incidence and variance of orthopedic diseases before and during the COVID-19 pandemic in Korea: a retrospective study
  20. 2040
    “…Synovial fluid (SF) was obtained from patients with PsA (n = 40), osteoarthritis (OA; n = 14), gout (n = 8), and rheumatoid arthritis (RA; n = 11) during clinical care. …”
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    Differential gene and protein expression of chemokines and cytokines in synovial fluid of patients with arthritis
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