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  1. 2041
    “…The expression of miR-146a is upregulated in the peripheral blood mononuclear cells of patients with inter-critical gout when compared to normouricemic and hyperuricemic controls and those patients with acute gout flares. …”
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    Mice with miR-146a deficiency develop severe gouty arthritis via dysregulation of TRAF 6, IRAK 1 and NALP3 inflammasome
  2. 2042
    Publicado 2020
    “…A comparative risk assessment approach was used to estimate the proportion of cardiovascular diseases and gout burden attributable to impaired kidney function. …”
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    Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
  3. 2043
    por Verschuur, Gerrit L
    Publicado 1993
    “…Magnets were thought useful to thieves, effective as a love potion or as a cure for gout or spasms. They could remove sorcery from women and put demons to flight and even reconcile married couples. …”
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    Hidden attraction: the history and mystery of magnetism
  4. 2044
    “…This paper describes the standardization of Somarajee taila, an important ayurvedic formulation indicated in scabies, pruritus, acne, fistula, gout, leprosy and ring worm.…”
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    STANDARDISATION OF SOMARAJEE TAILA
  5. 2045
    “…METHODS: Chemical constituents in the essential oil from leaves of Piper lolot were determined using GC/MS analysis. The anti-gout and anti-diabetic activities of the essential oil were determined through the inhibitory assays against xanthine oxidase, α-glucosidase and α-amylase enzymes. …”
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    Xanthine oxidase, α-glucosidase and α-amylase inhibitory activities of the essential oil from Piper lolot: In vitro and in silico studies
  6. 2046
    “…High serum uric acid levels, known as hyperuricemia (HUA), are associated with an increased risk of developing gout, chronic kidney disease, cardiovascular disease, diabetes, and other metabolic syndromes. …”
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    Biodegradation of Uric Acid by Bacillus paramycoides-YC02
  7. 2047
    por Lu, Na, Liu, Jing, Cai, Pan
    Publicado 2023
    “…The proportion of patients in the experimental group who developed gout was significantly lower than that in the control group(p=0.03). …”
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    Analysis of clinical efficacy of comprehensive nursing intervention on elderly patients with hypertension combined with hyperuricemia
  8. 2048
    “…OBJECTIVE: The aim of the study was to investigate the risk of prostate cancer among people with gout and/or hyperuricemia who used allopurinol and who did not use allopurinol. …”
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    A meta-analysis of allopurinol therapy and the risk of prostate cancer
  9. 2049
    Publicado 1995
    “…These results are in accordance with the pathological state of gout and pseudogout, where the predominant inflammatory cell is the neutrophil.…”
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    Inflammatory microcrystals differentially regulate the secretion of macrophage inflammatory protein 1 and interleukin 8 by human neutrophils: a possible mechanism of neutrophil recruitment to sites of inflammation in synovitis
  10. 2050
    “…OBJECTIVE—High serum uric acid levels lead to gout and have been reported to be associated with an increased risk of hypertension, obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. …”
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    Sex-Specific Association of the Putative Fructose Transporter SLC2A9 Variants With Uric Acid Levels Is Modified by BMI
  11. 2051
    “…Patients included in the Austrian Dialysis and Transplantation Registry (OEDTR) with unclear diagnoses or genetic diseases were asked whether they had (1) a family history of kidney disease or (2) had suffered from gout. Patients with gout and autosomal dominant renal disease underwent mutational analysis. …”
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    Epidemiology of Uromodulin-Associated Kidney Disease – Results from a Nation-Wide Survey
  12. 2052
    “…Allopurinol, the xanthine oxidase inhibitor, is the only drug available for the treatment of gout. We examined the xanthine oxidase inhibitory activity of some commercially available flavonoids such asepigallocatechin, acacatechin, myricetin, naringenin, daidzein and glycitein by virtual screening and in-vitro studies. …”
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    Virtual Screening Analysis and In-vitro Xanthine Oxidase Inhibitory Activity of Some Commercially Available Flavonoids
  13. 2053
    “…INTRODUCTION: Monosodium urate crystals (MSU), the etiological agent of gout, are one of the most potent proinflammatory stimuli for neutrophils. …”
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    Modulation of monosodium urate crystal-induced responses in neutrophils by the myeloid inhibitory C-type lectin-like receptor: potential therapeutic implications
  14. 2054
    “…Results. Data from 5,592 gout patients (72.6% male, mean age 63.7 years) were collected. …”
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    Urate Lowering Therapy with Febuxostat in Daily Practice—A Multicentre, Open-Label, Prospective Observational Study
  15. 2055
    “…INTRODUCTION: LC350189 is a novel selective xanthine oxidase inhibitor under clinical development for the management of hyperuricemia in gout patients. The aim of this study was to evaluate the pharmacokinetics, pharmacodynamics, and tolerability of the drug in healthy subjects. …”
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    Pharmacokinetics, pharmacodynamics, and tolerability of LC350189, a novel xanthine oxidase inhibitor, in healthy subjects
  16. 2056
    “…BACKGROUND: Gout gives rise to increased risk of cardiovascular events. …”
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    Impact of Urate Level on Cardiovascular Risk in Allopurinol Treated Patients. A Nested Case-Control Study
  17. 2057
    “…Pharmacogenetic studies implicated the role of ABCG2 in response to widely used medicines and anticancer agents, as well as in gout. Its Q141K variant exhibits decreased functional expression thus increased drug accumulation and decreased urate secretion. …”
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    Jump into a New Fold—A Homology Based Model for the ABCG2/BCRP Multidrug Transporter
  18. 2058
    por Singh, Jasvinder A., Yu, Shaohua
    Publicado 2017
    “…Age >50 years, Medicaid and self-pay as primary payer, Northeast U.S. hospital location, teaching hospital status, heart failure and diabetes were associated with longer hospitalization; hyperlipidemia, hypertension or gout were associated with a shorter hospital stay. …”
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    The burden of septic arthritis on the U.S. inpatient care: A national study
  19. 2059
    “…However, no clinical differences were observed in gout flares or tophi, although these were not the primary endpoints.…”
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    Lesinurad: what the nephrologist should know
  20. 2060
    “…In this study, 27 patients with acute gouty arthritis, 22 patients with intercritical gout (IG), and 20 healthy controls were recruited, and peripheral blood cells and plasma were collected for the detection of Th22, Th17, and Th1 cells, and plasma interleukin (IL)-22. …”
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    Increased circulating Th22 cells in patients with acute gouty arthritis: A CONSORT-compliant article
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