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  1. 2141
    “…We recently demonstrated significant involvement of uric acid and activation of the innate immune response in osteoarthritis (OA) pathology and progression, suggesting that traditional gout therapy may be beneficial for OA. We therefore assess colchicine, an existing commercially available agent for gout, for a new therapeutic application in KOA. …”
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    Colchicine effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): study protocol for a randomized controlled trial
  2. 2142
    “…OBJECTIVE: In this systematic review, we estimate the prevalence of six types of arthritis in Africa; namely rheumatoid arthritis, osteoarthritis, juvenile arthritis, psoriatic arthritis, gout, and ankylosing spondylitis. METHODS: We comprehensively searched literature on 31 August 2014 in MEDLINE, EMBASE, Web of Science and the Cochrane Library to identify eligible studies from 1975 up to 31 July 2014. …”
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    Prevalence of Arthritis in Africa: A Systematic Review and Meta-Analysis
  3. 2143
    “…The prevalence of RA and AS remained stable, whereas that of KOA, gout, and fibromyalgia has increased significantly in Shantou, China, during the past 3 decades. …”
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    Changes in the Prevalence of Rheumatic Diseases in Shantou, China, in the Past Three Decades: A COPCORD Study
  4. 2144
    “…Consumption of foods and beverages with high purine content increases the risk of hyperuricemia, which causes gout and can lead to cardiovascular, renal, and other metabolic disorders. …”
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    Functional and Structural Characterization of Purine Nucleoside Phosphorylase from Kluyveromyces lactis and Its Potential Applications in Reducing Purine Content in Food
  5. 2145
    “…INTRODUCTION: Lesinurad is a selective uric acid reabsorption inhibitor approved for the treatment of gout in combination with a xanthine oxidase inhibitor (XOI) in patients who have not achieved target serum uric acid (sUA) levels with an XOI alone. …”
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    Effects of renal function on pharmacokinetics and pharmacodynamics of lesinurad in adult volunteers
  6. 2146
    “…Gout/hyperuricemia is a common multifactorial disease having typical environmental risks. …”
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    Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors
  7. 2147
    “…These data support further clinical evaluation of once-daily verinurad as a treatment for gout.…”
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    Pharmacokinetics, pharmacodynamics, and tolerability of verinurad, a selective uric acid reabsorption inhibitor, in healthy adult male subjects
  8. 2148
    “…OBJECTIVES: Genetic variation in the renal urate transporters SLC2A9 (GLUT9) and SLC22A11 (OAT4) has been reported to interact with diuretics to increase the risk of developing gout. The aim of this study was to determine whether variation in SLC2A9 or SLC22A11 influences acute renal handling of uric acid in response to frusemide. …”
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    Influence of genetic variants on renal uric acid handling in response to frusemide: an acute intervention study
  9. 2149
    “…Continued investigation of verinurad is warranted in patients with gout and renal impairment. CLINICALTRIALS.GOV IDENTIFIER: NCT02219516.…”
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    Effect of Renal Impairment on the Pharmacokinetics and Pharmacodynamics of Verinurad, a Selective Uric Acid Reabsorption Inhibitor
  10. 2150
    por Martin, Keith R, Coles, Katie M
    Publicado 2019
    “…BACKGROUND: Gout is a frequently occurring, complex rheumatologic form of inflammatory arthritis caused by the accumulation of serum uric acid (sUA) and deposition of uric acid crystals in the joints and tissues of the body. …”
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    Consumption of 100% Tart Cherry Juice Reduces Serum Urate in Overweight and Obese Adults
  11. 2151
    “…CONCLUSION: We firstly reported skeletal deformity (fourth metatarsal microsomia), ovarian teratoma, and congenital ventricular septal defect as new phenotypes of PAX2‐related disorder which enlarged the phenotypic spectrum. Gout was firstly reported as the onset symptom of PAX2‐related disorder. …”
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    Diverse phenotypes in children with PAX2‐related disorder
  12. 2152
    “…The second set appeared unique to women: thyroid disease, osteoporosis, and gout/high uric acid. Identification of shared and unique gender-related associations between CHD and other conditions provides potential to tailor screening, preventive, and therapeutic options.…”
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    Gender-specific associations between coronary heart disease and other chronic diseases: cross-sectional evaluation of national survey data from adult residents of Germany
  13. 2153
    “…Nod-like receptor protein 3 (NLRP3)-mediated pyroptosis has a causal role in the pathogenesis of gout. P2Y(14) receptor (P2Y(14)R) distributed in immune cells including macrophages is a Gi-coupled receptor that inhibits the synthesis of cAMP, which has been regarded as a potential regulator of inflammatory response. …”
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    P2Y(14) receptor has a critical role in acute gouty arthritis by regulating pyroptosis of macrophages
  14. 2154
    “…Background The principal manifestation of hyperuricemia is gout. Many drugs are in use nowadays to treat gout, but they are linked with multiple side effects. …”
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    The Effect of Berberine, a Drug From Chinese Folk Medicine, on Serum and Urinary Uric Acid Levels in Rats With Hyperuricemia
  15. 2155
    “…The study has identified several risk factors, both specific (eg, knee injury and training dose) and nonspecific (eg, age and gout) to footballers. This may be used to develop prevention strategies to reduce the risk of KOA in professional footballers after retirement.…”
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    Risk Factors for Knee Osteoarthritis in Retired Professional Footballers: A Cross-Sectional Study
  16. 2156
    “…Conclusions: In this randomized trial of cancer survivors without gout, reductions in BMI either increased or did not change SU, potentially due to effects on eGFR. …”
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    Effects of a Behavioral Weight Loss Intervention and Metformin Treatment on Serum Urate: Results from a Randomized Clinical Trial
  17. 2157
    “…Subjects who already had diabetes mellitus, gout-related diseases, and any cancer prior to the index date were excluded. …”
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    A Head-To-Head Comparison of Benzbromarone and Allopurinol on the Risk of Type 2 Diabetes Mellitus in People With Asymptomatic Hyperuricemia
  18. 2158
    “…Women, age, rural, gout, painkillers were significant risk factors for both CKDu and elderly subjects. …”
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    Women and other risk factors for chronic kidney disease of unknown etiology in Thailand: National Health Examination V Survey
  19. 2159
    “…METHODS: In this randomized, double-blind, parallel-controlled phase II study, patients whose fasting serum uric acid (sUA) levels were ⩾ 480 μmol/L at screening with gout or sUA levels were ⩾ 420 μmol/L lasting for at least 3 months without gout, either with sUA levels ⩾ 540 μmol/L at screening or sUA levels ⩾ 480 μmol/L with comorbidities at screening, were enrolled. …”
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    Safety and efficacy of SHR4640 combined with febuxostat for primary hyperuricemia: a multicenter, randomized, double-blind, phase II study
  20. 2160
    “…Systematic review of 25 MR studies provided supporting evidence on five out of the eight disease outcomes, while the increased risk of gout, hyperparathyroidism and disorder of parathyroid gland were novel findings. …”
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    Health effects of high serum calcium levels: Updated phenome-wide Mendelian randomisation investigation and review of Mendelian randomisation studies
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