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  1. 2261
    “…His only other medical problem has been chronic recurrent gout requiring Allopurinol 300 mg daily, Probenecid 500mg twice daily and Colchicine 0.6mg twice daily to prevent gout attacks. …”
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    SUN-207 Hot Flashes, Flushing, and Sweating in a Middle-Aged Man with Pituitary Macroadenoma
  2. 2262
    “…METHODS: A cohort of 40 SF samples from 10 AS and 10 each of rheumatoid arthritis (RA), gout, and osteoarthritis (OA) patients were analyzed by liquid chromatography tandem mass spectrometry (LC–MS/MS) to identify differentially expressed proteins specific to AS. …”
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    Proteomic analysis of human synovial fluid reveals potential diagnostic biomarkers for ankylosing spondylitis
  3. 2263
    “…OBJECTIVES: Hyperuricemia is a metabolic condition central to gout pathogenesis. Urate exposure primes human monocytes towards a higher capacity to produce and release IL-1β. …”
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    Urate-induced epigenetic modifications in myeloid cells
  4. 2264
    “…Higher frequencies of association of hypertension, hyperlipidemia, coronary artery disease, cerebrovascular accidents, congestive heart failure, carotid artery stenosis, aortic aneurysm, peripheral artery disease, gout, and osteoarthritis were also seen in patients with DKD.…”
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    Risk Factors and Comorbidities Associated with Diabetic Kidney Disease
  5. 2265
    “…BACKGROUND: Gout is usually found in patients with atrial fibrillation (AF). …”
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    Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes
  6. 2266
    “…Empagliflozin reduced events of clinically relevant hyperuricaemia (acute gout, gouty arthritis or initiation of anti-gout therapy) by 32% [HR 0.68 (95% CI 0.52–0.89), P = 0.004]. …”
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    Uric acid and sodium-glucose cotransporter-2 inhibition with empagliflozin in heart failure with reduced ejection fraction: the EMPEROR-reduced trial( )
  7. 2267
    “…We present a case of a 78-year-old immunosuppressed renal transplant patient who was suspected of having gout but eventually was diagnosed with an unusual presentation of septic arthritis of the ankle secondary to blastomycosis.…”
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    Blastomyces dermatitidis Septic Arthritis in a Renal Transplant Patient
  8. 2268
    por Bovy, Valentin, Bogaert, Anne-Marie
    Publicado 2023
    “…Metabolic adverse events, especially hyperuricemia and gout, following the use of bempedoic acid are well documented. …”
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    Severe Hypertriglyceridemia After Use of Bempedoic Acid
  9. 2269
    “…Hence, this review discusses the anti-inflammatory effects of C-dots in in vivo and in vitro models of LPS-induced inflammation, gout, cartilage tissue engineering, drug-induced inflammation, spinal cord injury, wound healing, liver diseases, stomach cancer, gastric ulcers, acute kidney and lung injury, psoriasis, fever or hypothermia, and bone tissue regeneration. …”
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    Carbon Dots for the Treatment of Inflammatory Diseases: An Appraisal of In Vitro and In Vivo Studies
  10. 2270
    por Roman, Youssef M.
    Publicado 2023
    “…While high urate levels may contribute to developing gout and cardiometabolic disorders such as hypertension and insulin resistance, low urate levels may increase the risk for neurodegenerative diseases. …”
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    The Role of Uric Acid in Human Health: Insights from the Uricase Gene
  11. 2271
    “…Urate transporter 1 (URAT1) is a clinically validated target for the treatment of hyperuricemia and gout. Due to the absence of protein structures, the molecular design of new URAT1 inhibitors generally resorts to ligand-based approaches. …”
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    Discovery of Novel Biphenyl Carboxylic Acid Derivatives as Potent URAT1 Inhibitors
  12. 2272
    por Gabriel, Sherine E, Michaud, Kaleb
    Publicado 2009
    “…This progress is reviewed for the following major rheumatic diseases: rheumatoid arthritis (RA), juvenile rheumatoid arthritis, psoriatic arthritis, osteoarthritis, systemic lupus erythematosus, giant cell arteritis, polymyalgia rheumatica, gout, Sjögren's syndrome, and ankylosing spondylitis. …”
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    Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases
  13. 2273
    “…Febuxostat, a drug recently approved in the US, European Union and Japan for treatment of gout, inhibits xanthine oxidoreductase (XOR)-mediated generation of uric acid during purine catabolism. …”
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    Different inhibitory potency of febuxostat towards mammalian and bacterial xanthine oxidoreductases: insight from molecular dynamics
  14. 2274
    “…Given the important role of IL-1 in inflammatory diseases, from gout to rheumatoid arthritis, the importance of understanding the regulation of such a cytokine cannot be underestimated. …”
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    Innate instruction of adaptive immunity revisited: the inflammasome
  15. 2275
    “…Many conditions have similar radiographic appearances, including the calcinosis of chronic renal failure, calcific tendinitis, synovial osteochondromatosis, synovial sarcoma, myositis ossificans, tophaceous gout, and calcific myonecrosis. The radiologist plays a critical role in guiding the appropriate tests that can result in a conclusive diagnosis of tumoral calcinosis.…”
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    Tumoral Calcinosis Causing Bilateral Thigh Pain
  16. 2276
    “…In folk medicine, S. officinalis has been used for the treatment of different kinds of disorders including seizure, ulcers, gout, rheumatism, inflammation, dizziness, tremor, paralysis, diarrhea, and hyperglycemia. …”
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    Pharmacological properties of Salvia officinalis and its components
  17. 2277
    “…Over the years, allopurinol has been widely used as the preferred choice of urate lowering therapy in patients with gout. However, its role in patients with renal impairment is limited; and adverse reactions are well documented. …”
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    Successful febuxostat desensitization in a patient with febuxostat hypersensitivity: A Malaysian experience
  18. 2278
    “…A large number of enzyme inhibitors are used as drugs to treat several diseases such as gout, diabetes, AIDS, depression, Parkinson’s and Alzheimer’s diseases. …”
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    Recent Advances in Electrochemical Biosensors Based on Enzyme Inhibition for Clinical and Pharmaceutical Applications
  19. 2279
    “…Other systemic conditions that may mimic infectious crystalline keratopathy, such as multiple myeloma, gout or cystinosis were ruled out on each patient by laboratory testing. …”
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    Infectious crystalline keratopathy: Management of three cases with different risk factors
  20. 2280
    “…This inflammasome is involved in multiple neurodegenerative and metabolic disorders including Alzheimer’s disease, multiple sclerosis, type 2 diabetes mellitus, and gout. Therefore, therapeutic targeting to the NLRP3 inflammasome complex is a promising way to treat these diseases. …”
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    The Roles of the NLRP3 Inflammasome in Neurodegenerative and Metabolic Diseases and in Relevant Advanced Therapeutic Interventions
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