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  1. 2681
    “…CASE PRESENTATION: A 62-year-old Caucasian man with a generalized macular-vesicular rash involving 90% of his body surface area and mucous membranes, as well as impaired renal and hepatic functions following ingestion of allopurinol for treatment of gout, was admitted to our hospital. Skin biopsies were taken and he was started on a steroid infusion. …”
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    Acute compartment syndrome of the forearm as a rare complication of toxic epidermal necrolysis: a case report
  2. 2682
    “…(Globulariaceae) is a shrub growing in the Mediterranean basin and known to be used as a popular medicine for its several pharmacological properties against rheumatism, gout, typhoid, intermittent fever, and diabetes. …”
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    Active spermatogenesis induced by a reiterated administration of Globularia alypum L. aqueous leaf extract
  3. 2683
    “…None of the participants had atherosclerotic cardiovascular disease, chronic renal failure, systemic inflammatory disease, gout, or were under treatment which would affect serum UA level. …”
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    Serum Uric Acid Level and Diverse Impacts on Regional Arterial Stiffness and Wave Reflection
  4. 2684
    “…(Asteraceae), burdock, is a medicinal plant that is popularly used for treating hypertension, gout, hepatitis, and other inflammatory disorders. …”
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    Arctium lappa ameliorates endothelial dysfunction in rats fed with high fat/cholesterol diets
  5. 2685
    “…Analyses of synovial fluids and of tissue sections of patients suffering from gout revealed that NETs are also formed in vivo, especially during acute gouty flares and/or granuloma formation. …”
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    Bonding the foe – NETting neutrophils immobilize the pro-inflammatory monosodium urate crystals
  6. 2686
    “…Patients with acute infections, rheumatoid arthritis, gout, asthma, chronic lung disease, myocardial infarction, or apoplexy and those who had taken nonsteroidal anti-inflammatory drugs were exempted from the research because these variables could have impacted CRP. …”
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    The Prostate Cancer Patient Had Higher C-Reactive Protein Than BPH Patient
  7. 2687
    “…From episodic, longitudinal sequences of serum uric acid measurements in 4368 individuals we produced continuous phenotypic features that suggest multiple population subtypes, and that accurately distinguished (0.97 AUC) the uric-acid signatures of gout vs. acute leukemia despite not being optimized for the task. …”
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    Computational Phenotype Discovery Using Unsupervised Feature Learning over Noisy, Sparse, and Irregular Clinical Data
  8. 2688
    “…Here we report another Korean family with FJHN, in which three male members. a father and 2 sons.developed gout and progressive renal insufficiency. The clinical, laboratory, and radiological findings were consistent with FJHN, and renal biopsy showed chronic parenchymal damage, which can be found in FJHN but is not specific to this disease. …”
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    A Novel UMOD Mutation (c.187T>C) in a Korean Family with Juvenile Hyperuricemic Nephropathy
  9. 2689
    “…MATERIALS AND METHODS: A cross-sectional analytical study was conducted in 60 patients with T2D without a history of gout. None was treated with allopurinol. Venous blood samples were obtained in fasting state for determinations of serum creatinine, uric acid, and hemoglobin A(1c) (HbA(1c)) (reference range 3.8-5.5%); 24-h urine proteinuria was also measured. …”
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    Association of serum uric acid with proteinuria in type 2 diabetic patients
  10. 2690
    “…It is often characterized by hyperuricemia, gout, alteration of urine concentrating ability, as well as a variable rate of disease progression inconstantly leading to renal failure and histological alterations of the kidneys. …”
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    Standardized, Systemic Phenotypic Analysis of Umod (C93F) and Umod (A227T) Mutant Mice
  11. 2691
    “…Multiple logistic regression analysis showed that old age, a history of diabetes, gout and betel nut chewing, less exercise and albuminuria (odds ratio [OR], 2.75; p = 0.01) were risk factors for MetS, while a history of renal disease, diabetes and hypertension, and MetS (OR, 2.28; p = 0.01) were risk factors for albuminuria in occupational drivers; CONCLUSIONS: Our study demonstrated that MetS and albuminuria were public health problems in occupational drivers. …”
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    Association of Metabolic Syndrome and Albuminuria with Cardiovascular Risk in Occupational Drivers
  12. 2692
    “…Serum urate, the final breakdown product of purine metabolism, is causally involved in the pathogenesis of gout, and implicated in cardiovascular disease and type 2 diabetes. …”
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    Metabolite profiling reveals new insights into the regulation of serum urate in humans
  13. 2693
    “…Colchicine, a natural product of Colchicum autumnae currently used for gout treatment, is a tubulin targeting compound which inhibits microtubule formation by targeting fast dividing cells. …”
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    Novel Analogue of Colchicine Induces Selective Pro-Death Autophagy and Necrosis in Human Cancer Cells
  14. 2694
    “…BACKGROUND: Pegloticase is approved in the US for treatment of refractory chronic gout. Since chronic kidney disease (CKD) is common in these patients, we conducted a post-hoc analysis of 2 replicate phase 3 trials and the subsequent open-label extension study to determine the effects of pegloticase on renal function in patients with CKD stages 3 and 4, as well as the effects of renal dysfunction on pegloticase efficacy and safety. …”
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    Effect of pegloticase on renal function in patients with chronic kidney disease: a post hoc subgroup analysis of 2 randomized, placebo-controlled, phase 3 clinical trials
  15. 2695
    “…BACKGROUND: Elevated uric acid (UA) is commonly associated with gout and it is also a known cardiovascular disease risk factor. …”
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    Ependymal cells of the mouse brain express urate transporter 1 (URAT1)
  16. 2696
    “…OBJECTIVE: Uric acid is the end product of purine metabolism in humans, and increased serum uric acid concentrations lead to gout. The objective of the current study was to identify factors that are independently associated with serum uric acid concentrations in a cohort of Czech control individuals. …”
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    Metabolic Syndrome, Alcohol Consumption and Genetic Factors Are Associated with Serum Uric Acid Concentration
  17. 2697
    “…BACKGROUND: Maintenance of low serum urate levels is important for the management of gout. Achieving the recommended serum urate levels of less than 6.0 mg/dL is difficult in elderly (65 years of age or older) patients with renal impairment. …”
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    Efficacy and safety of febuxostat in elderly female patients
  18. 2698
    “…BACKGROUND: The genus Ajuga is used for the treatment of joint pain, gout, and jaundice in traditional Iranian medicine (TIM). …”
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    Antinociceptive effect of some extracts from Ajuga chamaecistus Ging. ssp. tomentella (Boiss.) Rech. f. aerial parts
  19. 2699
    por Dursun, Adile Berna, Sahin, Osman Z
    Publicado 2014
    “…CASE PRESENTATION: 75 year old male patient with gout, renal insufficiency, history of metastatic colorectal carcinoma status post-resection was referred to Allergy clinic for a maculopapular eruption that developed 1 week after initiating therapy with allopurinol. …”
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    Allopurinol desensitization with A 2 weeks modified protocol in an elderly patients with multiple comorbidities: a case report
  20. 2700
    “…PATIENTS AND METHODS: Patients with documented CAD were consecutively (nonrandomized) included in the study, and those with heart failure (ejection fraction < 50%), renal failure, gout, and insulin-treated diabetes were excluded. …”
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    Ramadan Fast in Patients With Coronary Artery Disease
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