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  1. 2741
    “…The SFMCs were dominated by a population of monocytes/macrophages in acute CPP crystal arthritis similar to that in acute gout. Synovial monocytes/macrophages showed the phenotypes of infiltrated monocytes as shown by expression of CD88, C-C chemokine receptor type 2, myeloid-related protein (MRP)8 and MRP14 but not proto-oncogene tyrosine-protein kinase MER. …”
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    Prominent Inflammatory Features of Monocytes/Macrophages in Acute Calcium Pyrophosphate Crystal Arthritis: a Comparison with Acute Gouty Arthritis
  2. 2742
    por Wang, Feifei, Ma, Zhuo, Wu, Xinan, Liu, Lihong
    Publicado 2019
    “…The patient, being newly diagnosed with gout 10 days ago, received allopurinol at a dose of 250 mg by mouth daily. …”
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    Allopurinol-induced toxic epidermal necrolysis featuring almost 60% skin detachment
  3. 2743
    “…BACKGROUND: Hesperitin, a naturally occurring flavonoid was hybridized with phenolic acids to evaluate its potential to inhibit the activity of xanthine oxidase (XO), a key enzyme which catalyses xanthine to uric acid which is found to be associated with gout and many life style related disorders. OBJECTIVE: To develop new xanthine oxidase inhibitors from natural constituents along with antioxidant potential. …”
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    In silico design and synthesis of hesperitin derivatives as new xanthine oxidase inhibitors
  4. 2744
    “…BACKGROUND: Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome. …”
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    In silico design and synthesis of targeted rutin derivatives as xanthine oxidase inhibitors
  5. 2745
    “…BACKGROUND: Clinically applied as anti-gout drugs, xanthine oxidoreductase (XOR) inhibitors, especially the potent, selective, non-purine-analog XOR inhibitors febuxostat and topiroxostat, exert organ-protective effects. …”
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    Metabolomics analysis elucidates unique influences on purine / pyrimidine metabolism by xanthine oxidoreductase inhibitors in a rat model of renal ischemia-reperfusion injury
  6. 2746
    por Alhubaishi, Alaa A.
    Publicado 2019
    “…CASE REPORT: A 55-year-old female patient with a past medical history of gout, depression, back pain, and type 2 diabetes was recently diagnosed with ulcerative colitis and was discharged with a new prescription of mercaptopurine. …”
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    Pancytopenia and Septic Infection Caused by Concurrent Use of Allopurinol and Mercaptopurine: A Case Report Illustrating the Importance of Clinical Pharmacist Consultation
  7. 2747
    “…SRE had anti-hyperuricemia effect and lowered the excessive level of uric acid, a potential factor for gout and kidney failure.…”
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    Toxicological Evaluation of Saposhnikoviae Radix Water Extract and its Antihyperuricemic Potential
  8. 2748
    “…ALPK1 is associated with chronic kidney disease, gout and type 2 diabetes mellitus. Raised renal ALPK1 level in patients with diabetes was reported. …”
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    ALPK1 regulates streptozotocin‐induced nephropathy through CCL2 and CCL5 expressions
  9. 2749
    “…Hyperuricemia (HU) is a cause of gout. Clinical studies show a link between HU and cardiovascular disease. …”
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    Urate‐lowering therapy alleviates atherosclerosis inflammatory response factors and neointimal lesions in a mouse model of induced carotid atherosclerosis
  10. 2750
    por Svanberg, Ingvar, Berggren, Åsa
    Publicado 2019
    “…It was a widespread belief that the formic acid could be used to cure various diseases, especially gout and rheumatism. Both anthills and the ants themselves were used for that purpose. …”
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    Ant schnapps for health and pleasure: the use of Formica rufa L. (Hymenoptera: Formicidae) to flavour aquavit
  11. 2751
    “…Gout is a prevalent and incapacitating disease triggered by the deposition of monosodium urate (MSU) crystals in joints, which are also massively infiltrated by neutrophils. …”
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    Cytokine Production and NET Formation by Monosodium Urate-Activated Human Neutrophils Involves Early and Late Events, and Requires Upstream TAK1 and Syk
  12. 2752
    “…All three patients given allopurinol to treat gout were diagnosed with DRESS syndrome. Symptom onset commenced 7-24 days after drug exposure; the patients took allopurinol (100–200 mg/d) for 2-30 days. …”
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    Allopurinol-induced severe cutaneous adverse reactions: A report of three cases with the HLA-B(*)58:01 allele who underwent lymphocyte activation test
  13. 2753
    “…There were 49 (13.7%) cases of culture-positive septic arthritis, and 47 patients underwent surgical irrigation and debridement. Gout and pseudogout crystals were present in 163 aspirates (45.5%). …”
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    Synovial Cell Count Poorly Predicts Septic Arthritis in the Presence of Crystalline Arthropathy
  14. 2754
    “…As a classical nonspecific anti-inflammatory drug, colchicine has been widely used in the treatment of acute gout. However, whether colchicine could alleviate CC-induced endothelial cell injury and the related mechanisms remains to be addressed. …”
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    Colchicine Alleviates Cholesterol Crystal-Induced Endothelial Cell Pyroptosis through Activating AMPK/SIRT1 Pathway
  15. 2755
    “…Uric acid crystal is known to activate the NLRP3 inflammasome and to cause tissue damages, which can result in many diseases, such as gout, chronic renal injury and myocardial damage. …”
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    Soluble uric acid induces myocardial damage through activating the NLRP3 inflammasome
  16. 2756
    “…The study showed no significant correlation between the major stone composition and dyslipidemia (DLP), hypertension (HT), gout, and body mass index (BMI) in both genders. …”
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    The correlation between demographic factors and upper urinary tract stone composition in the Thai population
  17. 2757
    “…The clinical differential diagnosis of glomus tumor includes Raynaud’s phenomenon, neuroma, gout, infection, peripheral neuropathy and radiculopathy. …”
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    Extra digital glomus tumor: A very rare cause of chronic abdominal wall pain
  18. 2758
    “…In the present study, serum levels of MASP2 were evaluated in 61 lupus patients and 98 healthy controls by training cohort, and then a validation cohort including 100 lupus, 100 rheumatoid arthritis, 100 osteoarthritis, 100 gout, 44 Sjogren's syndrome, 41 ankylosing spondylitis patients confirmed the findings. …”
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    Association of MASP2 levels and MASP2 gene polymorphisms with systemic lupus erythematosus
  19. 2759
    “…INTERVENTIONS: This patient was transferred to the intensive care unit and treated by reducing HTG, suppressing gastric acid, inhibiting trypsin activity, and relieving hyperuricemia and gout. OUTCOMES: Fifteen days after hospital admission, the patient had no complaints about abdominal pain and distention. …”
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    A case report of acute pancreatitis with glycogen storage disease type IA in an adult patient and review of the literature
  20. 2760
    “…RECENT FINDINGS: It is now becoming increasingly clear that, in many clinical conditions, elevated levels of uric acid have a much greater role beyond just causing gout. The present review will summarize current knowledge on the relation between hyperuricemia, CKD, and existing comorbidities, as well as the mechanisms of uric acid–related renal damage. …”
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    Management of Hyperuricemia in Patients with Chronic Kidney Disease: a Focus on Renal Protection
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