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3141por Tanaka, Kosuke, Yamanaga, Shigeyoshi, Hidaka, Yuji, Nishida, Sho, Kinoshita, Kohei, Kaba, Akari, Ishizuka, Toshinori, Hamanoue, Satoshi, Okumura, Kenji, Kawabata, Chiaki, Toyoda, Mariko, Miyata, Akira, Kashima, Masayuki, Yokomizo, Hiroshi“…We analyzed the relationship between preoperative UA levels and postoperative estimated glomerular filtration rate (eGFR), as well as adverse events (cardiovascular events and additional prescriptions for hypertension, gout, dyslipidemia, and diabetes mellitus), over 5 years after donation. …”
Publicado 2021
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3142“…OBJECTIVES: Hyperuricaemia is a risk factor for gout attacks, kidney damage and cardiovascular events. …”
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3143por Kuo, Yi-Wei, Hsieh, Shih-Hung, Chen, Jui-Fen, Liu, Cheng-Ruei, Chen, Ching-Wei, Huang, Yu-Fen, Ho, Hsieh-Hsun“…When purine metabolism is impaired, the serum UA level will be elevated (hyperuricemia) and eventually lead to gout. During evolution, humans and some primates have lost the gene encoding uricase, which is vital in UA metabolism. …”
Publicado 2021
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3144por George, Michael D., Baker, Joshua F., Banerjee, Shubhasree, Busch, Howard, Curtis, David, Danila, Maria I., Gavigan, Kelly, Kirby, Daniel, Merkel, Peter A., Munoz, George, Nowell, William Benjamin, Stewart, Patrick, Sunshine, William, Venkatachalam, Shilpa, Xie, Fenglong, Curtis, Jeffrey R.“…Adults with common ARD (rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus) or non‐ARD (gout, osteoarthritis, osteoporosis) were evaluated. …”
Publicado 2021
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3145por Leander, Jacob, Sunnåker, Mikael, Rekić, Dinko, Aksenov, Sergey, Eriksson, Ulf G., Johansson, Susanne, Parkinson, Joanna“…For verinurad, symptomatic hyperuricemic (gout) subjects showed a higher EC50 compared with healthy volunteers (37 ng/mL versus 29 ng/mL); while no significant difference was found for asymptomatic hyperuricemic patients. …”
Publicado 2021
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3146por Botelho, João, Machado, Vanessa, Proença, Luís, Alves, Ricardo, Cavacas, Maria Alzira, Mendes, José João“…Individual RD prevalence distribution in the study group were as follows: rheumatoid arthritis (RA) 23.3% (n = 7), fibromyalgia (FM) 36.7% (n = 11), systemic lupus erythematosus (SLE) 10.0% (n = 3), arthritis (ART) 13.3% (n = 4), gout 3.3% (n = 1), systemic scleroderma 3.3% (n = 1), FM + osteoarthritis (OA) 3.3% (n = 1), FM + SLE 3.3% (n = 1), FME + OA + ART 3.3% (n = 1). …”
Publicado 2021
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3147por Ogura, Masatsune, Toyoda, Yu, Sakiyama, Masayuki, Kawamura, Yusuke, Nakayama, Akiyoshi, Yamanashi, Yoshihide, Takada, Tappei, Shimizu, Seiko, Higashino, Toshihide, Nakajima, Mayuko, Naito, Mariko, Hishida, Asahi, Kawai, Sayo, Okada, Rieko, Sasaki, Makoto, Ayaori, Makoto, Suzuki, Hiroshi, Takata, Koki, Ikewaki, Katsunori, Harada-Shiba, Mariko, Shinomiya, Nariyoshi, Matsuo, Hirotaka“…This disease, which is increasing in prevalence worldwide, is associated with both gout and metabolic diseases. Several studies have reported relationships between apolipoprotein E (APOE) haplotypes and SUA levels in humans; however, their results remain inconsistent. …”
Publicado 2021
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3148“…Case 2: A 61-year-old man with alcohol use disorder and gout, presented with altered mental status. He had leukocytosis and acute kidney injury and was treated with vancomycin and cefepime with clinical improvement. …”
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3149por Martin, Susan, Tyrrell, Jessica, Thomas, E Louise, Bown, Matthew J, Wood, Andrew R, Beaumont, Robin N, Tsoi, Lam C, Stuart, Philip E, Elder, James T, Law, Philip, Houlston, Richard, Kabrhel, Christopher, Papadimitriou, Nikos, Gunter, Marc J, Bull, Caroline J, Bell, Joshua A, Vincent, Emma E, Sattar, Naveed, Dunlop, Malcolm G, Tomlinson, Ian PM, Lindström, Sara, Bell, Jimmy D, Frayling, Timothy M, Yaghootkar, Hanieh“…Here, MR with the FA and UFA genetics showed opposing effects on risk of disease: coronary artery disease, peripheral artery disease, hypertension, stroke, type 2 diabetes, polycystic ovary syndrome, heart failure, atrial fibrillation, chronic kidney disease, renal cancer, and gout. Second, 9 conditions where the non-metabolic effects of excess weight (e.g. mechanical effect) are likely a cause. …”
Publicado 2022
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3150por Yang, Huang-Yu, Hsu, Yun-Shiuan Olivia, Lee, Tao Han, Wu, Chao-Yi, Tsai, Chung-Ying, Chou, Li-Fang, Tu, Hui-Tzu, Huang, Yu-Tung, Chang, Shang-Hung, Yen, Chieh-Li, Hsieh, Meng-Hsuan, Lee, Cheng-Chia, Kuo, George, Hsiao, Chih-Yen, Lin, Hsing-Lin, Chen, Jia-Jin, Yen, Tzung-Hai, Chen, Yung-Chang, Tian, Ya-Chong, Yang, Chih-Wei, Anderson, Gerard F.“…METHODS: Pre-dialysis stage 5 CKD patients with gout were identified through the National Health Insurance Research Database (NHIRD) in Taiwan from 2012 to 2016. …”
Publicado 2022
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3151por Loosen, Sven H., Roderburg, Christoph, Curth, Ole, Gaensbacher, Julia, Joerdens, Markus, Luedde, Tom, Konrad, Marcel, Kostev, Karel, Luedde, Mark“…Non-cardiovascular diagnoses strongly associated with HF were obesity (HR = 1.46), chronic bronchitis and COPD (HR = 1.41), gout (HR: 1.41), and chronic kidney disease (HR = 1.27). …”
Publicado 2022
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3152por Zhou, Mi, Hua, Liang, Wang, Yi-Fei, Chen, Si-Ting, Yang, Chun-mei, Zhang, Ming, Li, Xin, Li, Bin“…BACKGROUND: Acute gouty arthritis (GA) is the main clinical manifestation and the most common initial symptom of gout. The treatment of acute GA involves the use of colchicine, non-steroidal anti-inflammatory drugs, and corticosteroids. …”
Publicado 2022
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3153por McDonald, Christopher L., Cohen, Brian H., Medina Pérez, Giancarlo, Modest, Jacob M., Kuris, Eren O., Born, Christopher“…Cardiovascular (P = .003), pulmonary (P = .001), gout (P = .002), or diabetes (P = .042) medications were associated with a higher likelihood for experiencing a complication. …”
Publicado 2022
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3154por Singh, Shailendra Kumar, Singh, Rina, Singh, Santosh Kumar, Iquebal, Mir Asif, Jaiswal, Sarika, Singh, Archana“…OBJECTIVE: Prevalence of hyperuricemia (HU) is increasing and it is associated with hypertension, metabolic syndrome, diabetes mellitus (DM), obesity, chronic kidney disease, gout and cardiovascular disease. Elevated level of serum uric acid (SUA) has been shown to be associated with hypertension and diabetes in many countries but there is lack of evidence from India. …”
Publicado 2022
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3155por Rao, Jiahuan, Ye, Peiyu, Lu, Jie, Chen, Bi, Li, Nan, Zhang, Huiying, Bo, Hui, Chen, Xinchun, Liu, Huiting, Zhang, Chunhong, Wei, Hua, Wu, Qin, Yan, Yinkun, Li, Changgui, Mi, Jie“…BACKGROUND AND AIMS: Hyperuricaemia can lead to gout and is associated with an increased risk of cardiometabolic disease. …”
Publicado 2022
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3156“…A total of 4152 Korean adults aged 45–76 years without T2DM, cancer, or gout at baseline in 2007–2008 from the Korean Genome and Epidemiology Study were followed up until 2016. …”
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3157por Weisshaar, Stefan, Litschauer, Brigitte, Reichardt, Berthold, Gruber, Felix, Leitner, Stefan, Sibinovic, Sasa, Kossmeier, Michael, Wolzt, Michael“…Patients with hyperuricemia and gout are at an increased risk for cardiovascular (CV) disease. …”
Publicado 2022
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3158“…RESULTS: Non-fixation treatment, male sex, older age (≥ 50 years old), diabetes mellitus, and gout were associated with a significantly higher risk of lower extremity PAOD compare to each comparison group, respectively. …”
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3159“…OBJECTIVES: Pegloticase rapidly lowers serum urate in uncontrolled/refractory gout patients, with ≥1 tophus resolution in 70% of pegloticase responders and 28% of non-responders. …”
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3160“…[Image: see text] Recombinant urate oxidase (UOX, E.C.1.7.3.3) is an important therapeutic enzyme used in preventing and treating chemotherapy-induced hyperuricemia and severe gout. However, UOX use is limited due to the poor stability and short plasma half-life. …”
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