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  1. 1761
    “…This study was performed to investigate the therapeutic effects and possible mechanisms of sunflower (Helianthus annuus) head extract (SHE) on gout. First, the components of sunflower head powder and SHE were analyzed systematically. …”
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    Anti-Gouty Arthritis and Antihyperuricemia Effects of Sunflower (Helianthus annuus) Head Extract in Gouty and Hyperuricemia Animal Models
  2. 1762
    “…OBJECTIVES: To explore patient perception of the role of a nurse-led complex package of care in facilitating engagement with urate-lowering therapies (ULTs) in the management of gout. METHODS: Thirty people who had participated in a randomised controlled trial investigating the effect of a nurse-led complex package of care for gout, were purposively sampled and interviewed between 18–26 months after the end of the trial. …”
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    Implication of nurse intervention on engagement with urate-lowering drugs: A qualitative study of participants in a RCT of nurse led care
  3. 1763
    “…Acute gout is an inflammatory response induced by monosodium urate (MSU) crystals. …”
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    HSP60 Regulates Monosodium Urate Crystal-Induced Inflammation by Activating the TLR4-NF-κB-MyD88 Signaling Pathway and Disrupting Mitochondrial Function
  4. 1764
    “…Our aim was to identify potentially functional or marked eccDNAs in gout patients. Methods: The Circle-Seq approach was applied for eccDNA detection from plasma in acute gout patients and healthy controls. …”
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    Characterization of Plasma Extrachromosomal Circular DNA in Gouty Arthritis
  5. 1765
    “…Gout is sterile joint inflammation triggered by the damaging effects of monosodium urate (MSU) crystals accumulation. …”
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    Downregulation of Transcription Factor T-Bet as a Protective Strategy in Monosodium Urate-Induced Gouty Inflammation
  6. 1766
    “…BACKGROUND: Gout is an inflammatory disease that is caused by the increased production of Interleukin-1β (IL-1β) stimulated by monosodium urate (MSU) crystals. …”
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    Single nucleotide polymorphisms associated with P2X7R function regulate the onset of gouty arthritis
  7. 1767
    “…INTRODUCTION: Chronic tophaceous gout classically occurs after 10 years or more of recurrent polyarticular gout. …”
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    Tophus of the Pubis Bone: A Case Report
  8. 1768
    “…Gout is a chronic arthropathy caused due to the deposition of monosodium urate crystals. …”
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    Fine-needle aspiration cytology of periarticular nodule – Atypical presentation of gouty tophi: A report of two cases
  9. 1769
    “…Gout is caused by the overproduction of uric acid and the inefficient metabolism of dietary purines in humans. …”
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    Decrystallization of Crystals Using Gold “Nano-Bullets” and the Metal-Assisted and Microwave-Accelerated Decrystallization Technique
  10. 1770
    “…Effects of febuxostat on serum cytokines interleukin (IL)-1, IL-4, IL-6, IL-8, tumor necrosis factor-α (TNF-α) and cyclooxygenase-2 (COX-2) in patients with gout were investigated. A total of 80 patients with gout admitted and treated in the Affiliated Zhongshan Hospital of Dalian University from January 2015 to September 2017 were selected and divided into two groups by virtue of a random number table, with 40 patients in each group. …”
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    Effects of febuxostat on serum cytokines IL-1, IL-4, IL-6, IL-8, TNF-α and COX-2
  11. 1771
    “…To explore the effects and mechanisms of the increased IL-33 expression in the gout patients, the anti-ST2 antibody and exogenous recombinant IL-33 were used in MSU-induced peritonitis animal model that mimics human gout. …”
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    IL-33 Ameliorates the Development of MSU-Induced Inflammation Through Expanding MDSCs-Like Cells
  12. 1772
    “…And TCM has been proved to be an effective method to treat gout in modern China. Nevertheless, the pharmacological mechanism of TCM for gout is still unclear, which limits its spread. …”
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    Advances in Experimental and Clinical Research of the Gouty Arthritis Treatment with Traditional Chinese Medicine
  13. 1773
    “…INTRODUCTION: Gouty tophi generally develop around 10 years after the first attack of gout in untreated patients and are commonly found around feet, hands, and elbows. …”
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    Atypical Presentation of Gouty Tophus as Posterior Cruciate Ligament Cyst: A Case Report
  14. 1774
    “…Febuxostat, initially developed as a xanthine oxidase inhibitor to address hyperuricemia in gout patients, has evolved into a versatile therapeutic agent with multifaceted applications. …”
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    Celebrating Versatility: Febuxostat’s Multifaceted Therapeutic Application
  15. 1775
    “…Thirty-one patients (49%) had histories involving some of the metabolic diseases investigated: 20 patients (32%) reported kidney stones, six (9.5%) gallstones, four (6.3%) gout and one (2%) concurrent diagnoses of kidney stones and gout. …”
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    CALCIFYING TENDINOPATHY: A LOCAL OR A SYSTEMIC CONDITION?
  16. 1776
    “…RATIONALE: Cervical ligamentum flavum gout (CLFG) is relatively rare, and its clinical manifestations are complicated; hence, it is often confused with ligamentum flavum ossification. …”
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    Percutaneous endoscopic treatment for cervical ligamentum flavum gouty tophus: A case report
  17. 1777
    “…An off-the-shelf Raman Spectrometer (RS) was used to noninvasively determine the presence of monosodium urate (MSU) crystals on the metatarsophalangeal joint (MTPJ) of a single gout sufferer. The spectrum sourced from the clinically diagnosed gout sufferer was compared to that sourced from an age-matched healthy subject scanned using the same protocol. …”
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    Raman Spectroscopy Applied to the Noninvasive Detection of Monosodium Urate Crystal Deposits
  18. 1778
    “…We present a case of a 62-year-old male with a history of chronic kidney disease stage 3, hypertension and gout who developed skin rash, eosinophilia, and renal impairment 2 weeks after he was started on allopurinol therapy for gout. …”
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    Skin rash, eosinophilia, and renal impairment in a patient recently started on allopurinol
  19. 1779
    “…Seasonality in the incidence and prevalence of gout has previously been reported but the cause of this seasonality in gout is not explained. …”
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    Seasonal variations of urate in a Swedish adult population
  20. 1780
    “…Multilevel analyses were performed to examine the association of physicians’ BMQ scores with the prescribed dosage of ULT, gout outcomes (number of gout flares, serum urate) and patients’ BMQ scores. …”
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    Beliefs of rheumatologists and general practitioners on urate lowering therapy: a cross-sectional study
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