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  1. 1781
    “…Gout is characterized by attacks of arthritis with hyperuricemia and monosodium urate (MSU) crystal-induced inflammation within joints. …”
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    Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation
  2. 1782
    “…However, studies on allosteric modulation of P2X7R in gout treatment are limited. Here, we aimed to investigate the therapeutic implications of targeting P2X7R in gout by designing a P2X7R allosteric inhibitor and validating the inhibitory function on NLRP3 inflammasome activation. …”
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    Z1456467176 alleviates gouty arthritis by allosterically modulating P2X7R to inhibit NLRP3 inflammasome activation
  3. 1783
    “…Gout in the spine and adnexa is rare in clinical practice and can also be easily misdiagnosed, we reported a patient with nerve root compression due to lumbar gout stones in the lumbar spinal canal. …”
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    Nerve root compression due to lumbar spinal canal tophi: A case report and review of the literature
  4. 1784
    “…The prevalence of gout and the adverse effects of current synthetic anti-gout drugs call for new natural and effective xanthine oxidase (XOD) inhibitors to target this disease. …”
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    Mining Xanthine Oxidase Inhibitors from an Edible Seaweed Pterocladiella capillacea by Using In Vitro Bioassays, Affinity Ultrafiltration LC-MS/MS, Metabolomics Tools, and In Silico Prediction
  5. 1785
    “…The aim of this study was to develop and validate a new radiographic damage scoring method (DAmagE index of GoUt; DAEGU) in chronic gout using plain radiography. …”
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    Simplified Radiographic Damage Index for Affected Joints in Chronic Gouty Arthritis
  6. 1786
    por Mahor, Durga, Prasad, Gandham S.
    Publicado 2018
    “…Gout is termed as crystallization of uric acid, predominantly within joints. …”
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    Biochemical Characterization of Kluyveromyces lactis Adenine Deaminase and Guanine Deaminase and Their Potential Application in Lowering Purine Content in Beer
  7. 1787
    por Viseltear, A. J.
    Publicado 1983
    “…Urinary lithiasis and gout were uncommonly prevalent in the eighteenth century. …”
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    The last illnesses of Robert and Horace Walpole.
  8. 1788
    “…BACKGROUND: Prevention of hyperuricaemia (HU) is critical to the prevention of gout. Understanding causal relationships and relative contributions of various risk factors to hyperuricemia is therefore important in the prevention of gout. …”
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    The comparative effect of exposure to various risk factors on the risk of hyperuricaemia: diet has a weak causal effect
  9. 1789
    “…Gout is the most common cause of monoarthritis in men occurring classically in the great toe and the knee. …”
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    Hearing loss due to urate deposition in the middle ear: A case report and literature review
  10. 1790
    “…RESULTS: Two taxa had a common causal effect on both gout and urate, whereas the Victivallaceae family was replicable. …”
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    Dissecting the causal effect between gut microbiota, DHA, and urate metabolism: A large-scale bidirectional Mendelian randomization
  11. 1791
    “…Sixty-nine differentially expressed proteins were found in gout, compared with OA, axSpA, and RA simultaneously. …”
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    TMT-Based Quantitative Proteomics Analysis of Synovial Fluid-Derived Exosomes in Inflammatory Arthritis
  12. 1792
    “…Colchicine has long been used as a systemic anti-inflammatory agent for treatment of gout by inhibiting mitotic activity and neutrophil function. …”
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    Colchicine-Induced Hepatotoxicity
  13. 1793
    por Wu, Wankun, Xu, Rong, Lv, Yingjun, Bao, Endong
    Publicado 2020
    “…In 2018, a new goose astrovirus (GAstrV) was reported in China, which causes 2 to 20% deaths in 4- to 16-day-old goslings causing great damages to the livestock industry. Gout is the typical feature of GAstrV infection in goslings. …”
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    Goose astrovirus infection affects uric acid production and excretion in goslings
  14. 1794
    “…Gout is more common in men than in women, by a factor of 3.1–10.1. …”
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    A brief review on in vivo models for Gouty Arthritis
  15. 1795
    “…The treatment of hyperuricemia and gout is mostly based on lowering serum uric acid levels using drugs, such as allopurinol, or increasing urinary excretion of uric acid. …”
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    Emodin, a Natural Anthraquinone, Increases Uric Acid Excretion in Rats with Potassium Oxonate-Induced Hyperuricemia
  16. 1796
    “…Most studies evaluated US as the basis for diagnosing crystal arthritis in already diagnosed cases of gout and few prospective studies have been performed. …”
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    A prospective evaluation of ultrasound as a diagnostic tool in acute microcrystalline arthritis
  17. 1797
    “…The expression of markers for monocyte recruitment and tissue-resident macrophages, the production of pro-inflammatory and anti-inflammatory cytokines, and phagocytosis were analyzed in the monocytes/macrophages of patients with acute gout attacks. The number and frequency of CD14(+)CD3(−)CD19(−)CD56(−) monocytes/macrophages was markedly increased in the SFMCs of patients with gout compared to those of patients with rheumatoid arthritis (RA). …”
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    CD14(+) Cells with the Phenotype of Infiltrated Monocytes Consist of Distinct Populations Characterized by Anti-inflammatory as well as Pro-inflammatory Activity in Gouty Arthritis
  18. 1798
    “…Conclusion: This nationwide population-based cohort study reveals that gout patients taking colchicine are at increased risk of developing pneumonia compared with gout patients who do not use colchicine. …”
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    The Association Between Usage of Colchicine and Pneumonia: A Nationwide, Population-Based Cohort Study
  19. 1799
    “…Dysregulation of the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome is associated with the pathogenesis of gout through the maturation of interleukin-1β. Piperine (PIP) is a phytochemical with an anti-inflammatory activity that has the potential as an alternative treatment for gout. …”
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    Immunosuppression by piperine as a regulator of the NLRP3 inflammasome through MAPK/NF-κB in monosodium urate-induced rat gouty arthritis
  20. 1800
    “…BACKGROUND: Gout is the most common type of inflammatory arthritis. …”
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    Effectiveness and safety of anakinra in gouty arthritis: A case series and review of the literature
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