“…RESULTS: At least one somatic hotspot mutation was detected in each of the 29 sequenced patients. A total of 42 somatic hot spot mutations were detected in tumor tissue DNA, and 39 mutations were detected in CTC-DNA, all of which included common changes in PTEN, MET, EGFR, RET, and FGFR3. …”
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“…We also demonstrated that fungal melanization occurs in the molds during the course of FK by applying a melanin-specific monoclonal antibody (MAb) that labeled fungal elements in corneal samples of patients, and melanin particles derived from the hyphae were also recovered after treatment of the samples with proteolytic enzymes, denaturant and hot concentrated acid. In summary, we demonstrate that northern Thailand has a high rate of FK that is influenced by season and males engaged in outside activities are at highest risk for disease. …”
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“…BACKGROUND: Perimenopausal women experience a wide variety of systemic symptoms: hot flashes, sweating, mental health concerns and various oral sensory complaints (OSC). …”
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“…However, only 15–25% of patients respond to the ICIs therapy, and methods to identify those responsive patients are currently a hot research topic. PD-L1 expression measured on tumor tissues using immunohistochemistry (IHC) was approved as one of the companion diagnostic methods, but it is invasive and cannot be used to monitor dynamic changes in PD-L1 expression during treatments. …”
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“…Unsupervised hierarchical cluster analysis revealed two patient groups with distinct protein profiles associated with high and low immune protein levels, designated as “hot” and “cold”. Further supervised cluster analysis based on T-cell activation markers showed that higher levels of T-cell activation markers were associated with longer progression-free survival (PFS) (p < 0.01). …”
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“…And especially for the lignocellulosic substrate with high lignin content such as liquid hot water pretreated corn stover and corncob residue, the promoting effect of Cip1 was even better than that of the commercial cellulase when adding equal amount protein. …”
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“…During the restriction's women consumed more bread (Odds Ratio (95% CI): 0.39 (0.18–0.83) p = 0.02); less battered fish: 3.11 (1.20–8.05) p = 0.02; and less hot chips/fries: 6.32 (2.67–14.93) p < 0.0001. During the restriction's women consumed more meals at home: 0.05 (0.14–0.15) p < 0.0001; less takeaways: 3.63 (1.54–7.34) p = 0.003; and less restaurant and café meals: 15.05 (6.03–37.59) p < 0.0001, when the services reopened. …”
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“…Overall average daily gain and body weight were greater for ETBA and TBA than CON (p ≤ 0.04), but not E2 (p ≥ 0.12). Feed efficiency and hot carcass weight were only greater than CON for ETBA (p ≤ 0.03). …”
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“…Space restriction decreased (P < 0.001) daily weight gain, final body weight, hot carcass weight, and daily feed intake, but increased carcass yield (P = 0.009) and decreased backfat depth (P = 0.003). …”
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“…RH- 647 for its novel plant structure and improved fiber quality heat and drought tolerant to withstand successfully sustain yield out in harsh, highly variable hot and dry climatic conditions of and harsh seasoned. …”
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“…The increase in resistance of microbes against conventional drugs is currently a hot issue, whereas diabetes is another main cause of mortalities encountered throughout the world after cancer and heart attacks. …”
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“…BACKGROUND: Whether the clinical effect of acupuncture in chronic pain is effective has always been a hot topic of research, which has a great relationship with the overall reporting descriptions of acupuncture, especially the sham acupuncture intervention. …”
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“…Testing for the existence and shape of the well-known EKC phenomenon is a hot topic in the environmental economics literature. …”
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“…The PC membranes were fabricated using semiconductor microelectromechanical manufacturing processes, precision micro-molding, and hot embossing. Amperometry was used to measure the glucose concentration in PBS (pH 7.4) and artificial human serum. …”
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“…It is of interest to evaluate crossbred pigs for hot carcass weight (HCW) and birth weight (BW); however, obtaining a HCW record is dependent on livability (LIV) and retained tag (RT). …”
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“…On the other side, the number of new infections decreases considerably during hot period closer to summer time. The geographic structure of our planet is such that when some countries (in a hemisphere) are in their winter season, others in the other hemisphere are in their summer season. …”
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“…This enables the assessment of West Africa regional air pollution hot spots in relationship to enhancing atmospheric factors. …”
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“…Cluster detection methodology was used to identify “hot” and “cold” spots for COVID-19 testing by place and race across New Castle County, DE. …”
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“…This study was aimed to observe the effects of EA on morphine-induced tolerance in mice and discover its underlying mechanism. Tail-flick assay and hot-plate test were conducted to assess the development of tolerance to morphine-induced analgesia effect. …”
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“…BACKGROUND: Households are hot spots for severe acute respiratory syndrome coronavirus 2 transmission. …”
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