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  1. 24121
    por Sviderskaya, Tatiana
    Publicado 2022
    “…Clinically, symptoms of vitamin D deficiency - decreased immunity, decreased muscle mass and strength, depression, and symptoms of estrogen deficiency (hot flashes, scanty menstruation, hair loss) persisted against a high 25(OH)D background, so estrogen determination was performed in the steroid profile of saliva. …”
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    PSAT217 Estrogen Deficiency as a Cause of Decreased 1- alpha - hydroxylase Activity
  2. 24122
    “…The cloned and expressed gene encoding ExnV1 was isolated from a thermophilic virus metagenome that was collected from several hot springs in Iceland. The structure of ExnV1, which contains the novel SβαR motif, was first determined to 2.19 Å resolution. …”
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    Crystal structure of DNA polymerase I from Thermus phage G20c
  3. 24123
    “…METHODS: We searched for systematic reviews and clinical guidelines on self-management strategies for AET side-effects (arthralgia, fatigue, hot flashes, gastrointestinal discomfort, nausea, vulvovaginal symptoms, and sleep disturbance). …”
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    Strategies to self-manage side-effects of adjuvant endocrine therapy among breast cancer survivors: an umbrella review of empirical evidence and clinical guidelines
  4. 24124
    “…PPIs are often described as containing an energetic “hot spot” for binding; in the case of LC3B-ATG4b, however, the substrate–enzyme complex contains multiple, energetically relevant domains that differentially affect binding affinity and catalytic efficiency.…”
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    LC3B Binds to the Autophagy Protease ATG4b with High Affinity Using a Bipartite Interface
  5. 24125
    “…In an ovarian tumor model, the photoacoustic-mediated PPIAO NPs combination therapy achieved a transition from “cold tumor” to “hot tumor” that promoted more CD8(+) T lymphocytes activation in vivo and intratumoral infiltration, and successfully inhibited the growth of primary and metastatic tumors. …”
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    Photoacoustic mediated multifunctional tumor antigen trapping nanoparticles inhibit the recurrence and metastasis of ovarian cancer by enhancing tumor immunogenicity
  6. 24126
    por Eryilmaz, Kurtulus, Kilbas, Benan
    Publicado 2022
    “…A detailed set of cold experiments were completed for optimization conditions before hot trials and TBA-HCO(3) increased molar activity with a minimum amount of side products. …”
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    A practical fully automated radiosynthesis of [(18)F]Flurpiridaz on the module modular lab-pharmtracer without external purification
  7. 24127
    “…We also investigate the comparison between two possible thermostatting configurations: the two ends connected (TEC) case in which there is at least a direct covalently connected path between the hot and cold heat baths, and the one end connected (OEC) case in which the system can be divided at least into two parts, by a vdW interacting interface. …”
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    Curvature and van der Waals interface effects on thermal transport in carbon nanotube bundles
  8. 24128
    “…Additionally, analyses of tumor immune landscapes demonstrated that higher TrMRS was correlated with more immune cell infiltration and “hot” immunological phenotype. TrMRS was also demonstrated to be positively correlated with the expression of multiple immunotherapy targets, including PD1 and PD-L1. …”
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    Prognosis prediction and tumor immune microenvironment characterization based on tryptophan metabolism-related genes signature in brain glioma
  9. 24129
    “…Finally, we describe our most recent progress in developing DNA NanoAntennas with Cleared HOtSpots (NACHOS) that are fully compatible with biomolecular assays. …”
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    DNA Origami Nanoantennas for Fluorescence Enhancement
  10. 24130
    “…Global warming has caused an increase in the frequency, duration, and intensity of summer heatwaves (HWs). Prolonged exposure to hot environments and orthostasis may cause conflicting demands of thermoregulation and blood pressure regulation on the vasomotor system, potentially contributing to cardiovascular complications and occupational heat strain. …”
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    Cardiovascular responses to orthostasis during a simulated 3-day heatwave
  11. 24131
    por Şakalar, Çağrı, Ertürk, Murat
    Publicado 2023
    “…For air disinfection analysis, different volumes of thyme oil were placed in a container with hot water and its vapor phase was tested against airborne/aerosolized SARS-CoV-2 in a 30 m(3) room. …”
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    Inactivation of airborne SARS-CoV-2 by thyme volatile oil vapor phase
  12. 24132
    “…Furthermore, analyses of the tumor immune microenvironment suggested that higher PuMRS was correlated with increased immune cell infiltration and gene expression signatures of “hotˮ tumors. Gliomas in the PuMRS high-risk group presented a higher expression level of multiple immune checkpoints, including PD-1 and PD-L1, and a better-predicted therapy response to immune checkpoint inhibitors. …”
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    Purine metabolism-related gene expression signature predicts survival outcome and indicates immune microenvironment profile of gliomas
  13. 24133
    “…IRT successfully detected 88% of shoulder sores as hot spots and provided a lead in time of 7 days. …”
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    Infrared Thermography for Early Identification and Treatment of Shoulder Sores to Improve Sow and Piglet Welfare
  14. 24134
    “…These data allowed us to observe a similar mortality rate compared to other studies carried out in Europe (0.09%) and to identify a significant increase in mortality during the hot season and when prolonged stops (>60 min.) were carried out during long journeys. …”
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    Mortality during Transport of Pigs Subjected to Long Journeys: A Study in a Large European Abattoir
  15. 24135
    “…Giardia duodenalis (G. duodenalis) is an infectious protozoan that has a global distribution especially in the hot climate. Around 200 million people are infected worldwide annually by Giardia, but infection is not always accompanied by symptoms, especially in endemic countries. …”
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    Role of anti-Giardia recombinant cyst wall protein IgG polyclonal antibodies in diagnosis and protection
  16. 24136
    “…Dry matter intake, daily weight gain (DWG), total kg gained (KgT), feed conversion (FC), and feed efficiency (FE) were evaluated; upon reaching the weight for sale, the animals were slaughtered, and hot carcass weight (HCW) was evaluated. The results were analyzed with a completely randomized design with repeated measures. …”
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    Effect of replacing soybean meal (Glycine max) with sesame meal (Sesamum indicum) on productive traits, carcass characteristics, and gross profit margin in fattening lamb’s diets
  17. 24137
    “…A comprehensive reference analysis demonstrated NR3C1 gene methylation, FKBP5 DNA methylation, BDNF DNA methylation, and KITLG methylation have been hot spots in epigenetic studies in the field of childhood trauma in recent years. …”
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    Emerging trends in epigenetic and childhood trauma: Bibliometrics and visual analysis
  18. 24138
    “…Ischemic acute kidney injury (AKI) has always been a hot and difficult research topic in the field of renal diseases. …”
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    No safe renal warm ischemia time—The molecular network characteristics and pathological features of mild to severe ischemia reperfusion kidney injury
  19. 24139
    “…The TP53 gene is mutated in 80% of triple-negative breast cancers. Cells that harbor the hot-spot p53 gene mutation R273H produce an oncogenic mutant p53 (mtp53) that enhances cell proliferative and metastatic properties. …”
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    The C-terminus of Gain-of-Function Mutant p53 R273H Is Required for Association with PARP1 and Poly-ADP-Ribose
  20. 24140
    por Abassi, Rahibu A., Msengwa, Amina S.
    Publicado 2022
    “…We simulated incomplete datasets with 15, 30, 45 and 60% of missingness under Missing At Random (MAR) and Missing Completely At Random (MCAR) mechanisms. Mean imputation, hot deck, k-nearest neighbour, multiple imputations via chained equation, expected-maximisation, and predictive mean matching were used to impute incomplete datasets. …”
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    Classification of breast cancer recurrence based on imputed data: a simulation study
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