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  1. 24521
    “…Of that, subtype C1 was an immune-cold type in lack of immune regulators, subtype C2, with an immunosuppression-dominated phenotype characterized by robust TGFβ signaling and stromal reaction, showed the worst prognosis, subtype C3 was an immune-hot type, with massive immune cell infiltration and in abundance of immune regulators. …”
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    Immune subtyping for pancreatic cancer with implication in clinical outcomes and improving immunotherapy
  2. 24522
    “…BACKGROUND: Assessments of cortical development and identifying factors that may result in a poor prognosis for fetuses with isolated mild ventriculomegaly (IMVM) is a hot research topic. We aimed to perform a constant, detailed assessment of cortical development in IMVM fetuses using ultrasound and determine whether asymmetric cortical development occurred. …”
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    Asymmetric cortical development and prognosis in fetuses with isolated mild fetal ventriculomegaly: an observational prospective study
  3. 24523
    por Zyoud, Sa’ed H.
    Publicado 2021
    “…VOSviewer 1.6.16 software was applied to generate a network map to assess hot topics in this area and determine the collaboration patterns between different countries. …”
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    The Arab region’s contribution to global COVID-19 research: Bibliometric and visualization analysis
  4. 24524
    “…Noteworthy, tropical and subtropical animal breeds are productively suited to hot climate conditions. Therefore studying the physiological changes accompanying high temperature, especially in tropically adapted species such as buffalo, will help in understanding the mechanisms that the animal use to accomplish the necessary functions efficiently. …”
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    Adaptive and Biological Responses of Buffalo Granulosa Cells Exposed to Heat Stress under In Vitro Condition
  5. 24525
    “…Maternal fatty acid supplementation during late gestation modified growth, insulin sensitivity, and hot carcass weight in lambs; these changes depended on the unsaturation degree of the fatty acid supplement and lamb sex. …”
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    Maternal Supply of Fatty Acids during Late Gestation on Offspring’s Growth, Metabolism, and Carcass Characteristics in Sheep
  6. 24526
    “…CONCLUSIONS: Both mild cold and mild hot temperatures may significantly increase the risk of AR outpatients in Xinxiang, China. …”
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    Changes in ambient temperature increase hospital outpatient visits for allergic rhinitis in Xinxiang, China
  7. 24527
    “…YM155 simultaneously targets three “hot” spots on PLpro, including the substrate-binding pocket, the interferon stimulating gene product 15 (ISG15) binding site and zinc finger motif. …”
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    High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors
  8. 24528
    “…Here we aim to review the interactions between arid environments and the microbial communities which inhabit them, covering hot and cold deserts, the challenges these environments pose and some issues arising from limitations in the field. …”
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    A rather dry subject; investigating the study of arid-associated microbial communities
  9. 24529
    “…The deactivation promoted a “hot” tumor microenvironment and enhanced the sensitivity to immune checkpoint blockade with antibody against the cytotoxic T-lymphocyte antigen 4 (CTLA-4). …”
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    CD80 Expression on Tumor Cells Alters Tumor Microenvironment and Efficacy of Cancer Immunotherapy by CTLA-4 Blockade
  10. 24530
    “…A thyroid uptake scan followed, which showed heterogeneous activity in the thyroid gland, (12% and 32% uptake at 6 and 24 hours respectively) with focal increased uptake in the medial lobes, without cold nodules or hot nodules. Repeat TFTs one month later showed a suppressed TSH <0.010 mIU/L, and a normal FT4 1.3 ng/dL. …”
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    A Grave Case of COVID-19: SARS-CoV-2 Induced Autoimmune Hyperthyroidism
  11. 24531
    “…It not only learns the diversified information from RNA sequences encoded by p-nucleotide and one-hot encodings, but also takes advantages of lncRNA-LSTM proposed in our previous study and CNN. …”
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    PlncRNA-HDeep: plant long noncoding RNA prediction using hybrid deep learning based on two encoding styles
  12. 24532
    “…In clinical practice, these results open up perspectives for the development of more specific cognitive remediation programs (one specific program for cold cognitions and another specific program targeting emotions and hot cognitions). These results warrant confirmation by larger studies with a more specific evaluation of the impact of emotional status. …”
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    Evaluation of cognitive impairment in a French sample of patients with restrictive anorexia nervosa: two distinct profiles emerged with differences in impaired functions and psychopathological symptoms
  13. 24533
    “…Targeting MYCN or its effectors could be a strategy to convert a cold TME into a ‘hot’ (inflamed) TME and improve the efficacy of ICB therapy. …”
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    Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma
  14. 24534
    “…Also, a structure of vascular bundles existed in the hilar region. Hot water treatment caused the tightly closed micropyle to open and the cavity beneath it expanded; the layer of palisade cells in the lens was raised. …”
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    Identification of the initial water-site and movement in Gleditsia sinensis seeds and its relation to seed coat structure
  15. 24535
    “…Participants perceived SSB as providing hydration and energy, particularly in hot weather. Lastly, if consumed in moderation, SSB were thought to have no direct adverse health consequences. …”
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    A qualitative analysis of the perceived socio-cultural contexts and health concerns of sugar-sweetened beverages among adults studying or working at a post-secondary institution in Dharwad, India
  16. 24536
    “…Policymakers and health planners should intervene in nutrition intervention at the identified hot spot areas to reduce the poor consumption of foods rich in vitamin A among children aged 6–23 months.…”
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    Spatial distribution and geographical heterogeneity factors associated with poor consumption of foods rich in vitamin A among children age 6–23 months in Ethiopia: Geographical weighted regression analysis
  17. 24537
    “…The role of wastewater treatment plants (WWTPs) as hot spots for the dissemination of AMR and MDR has been widely pointed out by the scientific community. …”
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    Increased Antimicrobial and Multidrug Resistance Downstream of Wastewater Treatment Plants in an Urban Watershed
  18. 24538
    “…Approximately 2/3 of the increase in gain efficiency remained after 8 d of removal. Hot carcass weight was increased by 6 kg (P = 0.02) by feeding ractopamine with a 0-d withdrawal compared to the control. …”
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    Effects of voluntary removal of ractopamine hydrochloride (Optaflexx) on live performance and carcass characteristics of beef steers
  19. 24539
    “…Most FLWs (68%–90%) restored service provision in July 2020, except for immunization and hot cooked meals (<10%). Administrative data showed similar patterns of disruption and restoration. …”
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    COVID-19 Disrupted Provision and Utilization of Health and Nutrition Services in Uttar Pradesh, India: Insights from Service Providers, Household Phone Surveys, and Administrative Data
  20. 24540
    “…Furthermore, we identified two main immune subtypes of OSCC (immune-hot and immune-cold) which harbored characteristic TIIs infiltrations and genomic and molecular features, and associated with patient survival. …”
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    Immune landscape and subtypes in primary resectable oral squamous cell carcinoma: prognostic significance and predictive of therapeutic response
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