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  1. 24661
    “…Further investigation with transcriptomics verified that tumors with high TILs predicted by radiomics (Rad-TILs) presented activated immune-related pathways, such as antigen processing and presentation, and immune checkpoints pathways. In addition, a hot immune microenvironment, including upregulated T cell infiltration gene signatures, cytokines, costimulators and major histocompatibility complexes (MHCs), as well as more CD8(+) T cells, follicular helper T cells and memory B cells, was found in high Rad-TILs tumors. …”
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    Radiomics features for assessing tumor-infiltrating lymphocytes correlate with molecular traits of triple-negative breast cancer
  2. 24662
    “…The antinociceptive efficacy of the compound (50 mg/kg, i.p.) was investigated using formalin and hot plate assays in mice. The role of the opioid system was also investigated. …”
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    A 9-aminoacridine derivative induces growth inhibition of Ehrlich ascites carcinoma cells and antinociceptive effect in mice
  3. 24663
    “…More than 60% of both types of carcinomas patients were hot tea drinkers. CONCLUSION: Current study demonstrated that most patients diagnosed with esophageal cancers were male, uneducated, belongs to low-income groups, lives in rural areas. …”
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    Risk factors associated with esophageal cancers, diagnosed at tertiary level in Afghanistan: a descriptive cross-sectional study
  4. 24664
    “…A 24-year-old woman was referred to endocrinology for 60-pound weight gain, acne, hirsutism, generalized weakness, heat intolerance, and hot flashes. She had secondary amenorrhea for 6 months prior to presentation. …”
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    PSAT041 A Rare Case of Severe Cyclical Cushing Syndrome Due to Ectopic ACTH Secretion by Appendiceal Carcinoid
  5. 24665
    por Sharma, Rajeev
    Publicado 2022
    “…A radioactive scan in 1/2017 showed normal 24-hour uptake (12%) with no hot or cold nodules. (Fig 1). Since starting levothyroxine, the dose has been adjusted few times and patient has been doing well. …”
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    PSAT342 Hypothyroidism After Use Of Immune Checkpoint Inhibitor Therapy In Patient With Graves’ Disease
  6. 24666
    “…Exercise in a hot and humid environment may endanger athlete’s health and affect physical performance. …”
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    Performance effects of internal pre- and per-cooling across different exercise and environmental conditions: A systematic review
  7. 24667
    “…Emissions were concentrated in hotspots and hot moments. A better understanding of the driving factors of N(2)O production and reduction in (rewetted) fens is essential and stable isotope methods including measurements of (15)N and (18)O as well as site preferences can help foster the necessary comprehension of the underlying mechanisms. …”
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    Influence of rewetting on N(2)O emissions in three different fen types
  8. 24668
    “…BACKGROUND: With an increasing incidence of obesity, the relationship between obesity and body image has become a hot research topic worldwide. From high school to university, young people experience changes in their social environment. …”
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    Relationship between body dissatisfaction, insufficient physical activity, and disordered eating behaviors among university students in southern China
  9. 24669
    “…The cubical cavity of 0.7 m side-length is set to have a temperature difference of 39 K between the two facing cold and hot vertical walls. As a first step, the carrier fluid flow was validated by comparing the first and second-moment statistics against both previous well-resolved LES and experimental databases [Kalilainen (J. …”
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    CFD Simulation of Particle-Laden Flow in a 3D Differentially Heated Cavity Using Coarse Large Eddy Simulation
  10. 24670
    “…Electrophoretic deposition (EPD) coating has become a hot topic due to its simple experiment, wide application, and wide material range. …”
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    Kinetics study of anodic electrophoretic deposition for polytetrafluoroethylene (PTFE) coatings on AZ31 magnesium alloy
  11. 24671
    “…The vaccine antigen contains four hot spot substitutions, K417N, E484K, N501Y and D614G, based on a prefusion-stabilized spike trimer of SARS-CoV-2 (S-6P) and formulated with an Alum/CpG 7909 dual adjuvant system. …”
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    A potent, broadly protective vaccine against SARS-CoV-2 variants of concern
  12. 24672
    “…Utility assessments explored 4 ADT-related side effects: hot flashes, fatigue, loss of libido/erectile dysfunction, and weight gain. …”
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    Patients’ Preferences for Androgen Deprivation Therapy in the Treatment of Intermediate-Risk Prostate Cancer
  13. 24673
    “…Quality scores were analysed by hot spot analysis and inverse distance weighting. …”
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    Service quality and accessibility of healthcare facilities: digital healthcare potential in Ho Chi Minh City
  14. 24674
    “…Regime shift detection identified twelve warm and nine cold significant regime shifts in our summer Tmax reconstructions. The longest hot summer period occurred in the twentieth century, and two warm regime shifts occurred in 1999 and 2008. …”
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    Tree-ring-based seasonal temperature reconstructions and ecological implications of recent warming on oak forest health in the Zagros Mountains, Iran
  15. 24675
    “…Therefore, all HIV responders should target their prevention efforts toward hot spot areas and sub-populations to stop further transmission.…”
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    Recent HIV infection among newly diagnosed cases and associated factors in the Amhara regional state, Northern Ethiopia: HIV case surveillance data analysis (2019-2021)
  16. 24676
    “…The mean percentage of the injected dose per mL of (18)F-FET PET correlated with the mean %CEST (r = 0.67, P < 0.05), but there was also a qualitative difference in hot spot location within the tumor, indicating complementary information regarding the tumor cell demand for amino acids and tumor intracellular mobile phase protein levels. …”
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    Use of multimodality imaging, histology, and treatment feasibility to characterize a transgenic Rag2-null rat model of glioblastoma
  17. 24677
    “…Since the genomic SCCmec integration site is a hot-spot of recombination, occasional losses of elements of 16 kb size may restore capacities for the uptake of foreign genetic material. …”
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    How to survive pig farming: Mechanism of SCCmec element deletion and metabolic stress adaptation in livestock-associated MRSA
  18. 24678
    “…CONCLUSION: The hydrogel encapsulating DOX and highly permeable Rg3-PNPs provided an efficient strategy for remodeling immunosuppressive tumor microenvironment and converting immune “cold” 4T1 into “hot” tumors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40824-022-00329-8.…”
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    Ginsenoside Rg3 nanoparticles with permeation enhancing based chitosan derivatives were encapsulated with doxorubicin by thermosensitive hydrogel and anti-cancer evaluation of peritumoral hydrogel injection combined with PD-L1 antibody
  19. 24679
    “…BACKGROUND: Peru has one of the highest rates of multidrug-resistant tuberculosis (MDR-TB) in the Latin America region, with Callao being one of the hot spots. We sought to identify resistance patterns and key drivers of recent MDR-TB transmission in Callao, Peru. …”
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    2355. Prison as a Driver of Recent Transmissions of Multidrug-Resistant Tuberculosis in Callao, Peru
  20. 24680
    “…RESULTS: From among 145 women each, in urban and rural settings, most common psychosomatic symptoms were physical exhaustion-fatigue (73.1%), difficulty climbing stairs (59.3%), sleep problems (45.2%), body ache (43.4%), and hot flushes (41.4%). Among the urban participants, most common was physical exhaustion (42.1%), difficulty climbing stairs (62.1%), anger (46.9%), sleep problems (45.5%), and irritability (42.1%), while among the rural participants they were physical exhaustion (66.2%), difficulty climbing stairs (56.6%), insomnia (54.5%), and body ache (46.2%). …”
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    Prevalence of menopausal symptoms among women in Vadodara, Central Gujarat: The urban-rural divide
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