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  1. 24701
    “…Functional and immune infiltration analysis demonstrated that lower risk scores tended to associate with immunologically “hot” status in RCC. CONCLUSIONS: Our 10-gene mutation classifier was found to be a biomarker for predicting the overall survival of patients with advanced RCC to ICI therapy.…”
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    Development and validation of a novel defined mutation classifier based on Lasso logistic regression for predicting the overall survival of immune checkpoint inhibitor therapy in renal cell carcinoma
  2. 24702
    “…Molecular interaction, hydrogen bond and per-residue decomposition analyses predicted Arg400, Arg401, Lys519, Trp687, Glu689, and Lys690 as hot-spot residues in the ADAR2 IHP binding site. …”
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    Molecular Docking and Dynamics Simulation Studies Predict Potential Anti-ADAR2 Inhibitors: Implications for the Treatment of Cancer, Neurological, Immunological and Infectious Diseases
  3. 24703
    “…The four-component reaction of 5-R-isatins (R = H, CH(3)), malononitrile, monothiomalonamide (3-amino-3-thioxo- propanamide) and triethylamine in hot EtOH yields a mixture of isomeric triethylammonium 6′-amino-3′-(aminocarbonyl)-5′-cyano-2-oxo-1,2-dihydro-1′H- and 6′-amino-3′-(aminocarbonyl)- 5′-cyano-2-oxo-1,2-dihydro-3′H-spiro[indole-3,4′-pyridine]-2′-thiolates. …”
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    New 6′-Amino-5′-cyano-2-oxo-1,2-dihydro-1′H-spiro[indole-3,4′-pyridine]-3′-carboxamides: Synthesis, Reactions, Molecular Docking Studies and Biological Activity
  4. 24704
    por Wang, Junna, Feng, Yu, Zong, Zhiyong
    Publicado 2023
    “…Our study underscores that the chromosomal region containing the capsule gene cluster is a hot spot of recombination in K. pneumoniae. This represents a major evolutionary mechanism employed by some bacteria for rapid evolution with novel clades that accommodate stress for survival.…”
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    The Origins of ST11 KL64 Klebsiella pneumoniae: a Genome-Based Study
  5. 24705
    “…OBJECTIVE: This study aimed to understand the main topics and communication characteristics of hot papers related to COVID-19 vaccine on the WeChat platform and assess the health behavior theory application with the aid of health belief model (HBM). …”
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    COVID-19 Vaccine–Related Information on the WeChat Public Platform: Topic Modeling and Content Analysis
  6. 24706
    por Zhang, Xiaoyan, Xing, TianJun
    Publicado 2023
    “…With the combination of knot-free suture and renal segment vascular occlusion, hot ischemic kidney damage is reduced. In the RLPN group, there were no complications of urinary fistula and bleeding, and no abnormal changes in renal function during follow-up. …”
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    Evaluation of the safety of retroperitoneal laparoscopic partial nephrectomy by investigating the perioperative indicators
  7. 24707
    “…The majority of patients were admitted for an integumentary burn (87.6%) with the most common cause being flame (49.8%) or hot water contact (19.0%). Compliance with the decolonization protocol was appropriate for 87.6% of patients post-intervention. …”
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    700 Implementation of an Intranasal Decolonization Protocol and Line Changing Policy in Adult Burn Patients
  8. 24708
    “…METHODS: Sprague-Dawley rats were subjected to a hot comb burn contact injury using a 150-g brass comb preheated to 100°C, to create four rectangular burns, separated by three unburned interspaces. …”
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    75 Tranexamic Acid Reduces Burn Wound Conversion and Lung Inflammation in a Murine Comb Burn Model
  9. 24709
    “…Finally, the neural behavior of all the animals was tested using a hot plate tester, open-field test and Y-type electric maze. …”
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    Transcriptomics-based investigation of manganese dioxide nanoparticle toxicity in rats’ choroid plexus
  10. 24710
    “…The objective was to validate molecular markers associated with milk production and thermotolerance traits in Holstein cows managed in a hot and humid environment. Lactating cows (n = 300) exposed to a heat stress environment were genotyped using a medium-density array including 53,218 SNPs. …”
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    Genetic Markers Associated with Milk Production and Thermotolerance in Holstein Dairy Cows Managed in a Heat-Stressed Environment
  11. 24711
    “…WES revealed a homozygous missense variant on chromosome 12, the NM_052845.4 (MMAB):c.557G > A, p.Arg186Gln, in exon 7, a highly conserved and hot spot region for pathogenic variants. After being confirmed by Sanger sequencing, the wild-type and mutant proteins’ structure and function were modeled and examined using in-silico bioinformatics tools and compared to the variant NM_052845.4 (MMAB):c.556C > T, p.Arg186Trp, a known pathogenic variant at the same position. …”
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    Identifying and predicting the pathogenic effects of a novel variant inducing severe early onset MMA: a bioinformatics approach
  12. 24712
    “…RESULTS: We identified two distinct DAMP molecular subtypes, and there are remarkable differences in survival probability between the two subtypes, and patients with higher levels of DAMP-related genes are “hot tumors” with increased immune activity. In addition, 9 DAMP genes were selected as prognostic signature genes, and clinical outcomes and immunotherapy response were better for participants in the low-risk group. …”
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    An ICD-Associated DAMP Gene signature predicts survival and immunotherapy response of patients with lung adenocarcinoma
  13. 24713
    “…Mechanical and thermal thresholds were measured using Von Frey filaments and hot plate tests. C-Fos expression was measured by western blotting and immunofluorescence staining to assess the central sensitization. …”
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    PACAP6-38 improves nitroglycerin-induced central sensitization by modulating synaptic plasticity at the trigeminal nucleus caudalis in a male rat model of chronic migraine
  14. 24714
    “…CONCLUSIONS: Hypermutant RRD-medulloblastoma reveal heterogenous phenotypes due to unique spectrum of driver mutations and an early cell of origin. Their immune-hot microenvironment allows successful salvage treatment with checkpoint-inhibitors for those failing chemo-radiation, including the high-risk SHH/TP53-mutant and unclassified subgroups.…”
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    MDB-12. TRANS-SPECIES ANALYSIS OF REPLICATION-REPAIR DEFICIENT (RRD) MEDULLOBLASTOMA AND RESPONSE TO IMMUNE-CHECKPOINT INHIBITION: AN IRRDC REPORT
  15. 24715
    “…OBJECTIVE: Population ageing, as a hot issue in global development, increases the burden of medical resources in society. …”
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    Spatio-temporal pattern, matching level and prediction of ageing and medical resources in China
  16. 24716
    “…SIMPLE SUMMARY: Hydrothermal vents are regions such as hot springs found on the seafloor in the mid-ocean and near tectonic plates. …”
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    Genome Study of α-, β-, and γ-Carbonic Anhydrases from the Thermophilic Microbiome of Marine Hydrothermal Vent Ecosystems
  17. 24717
    “…OBJECTIVE: To visualize and analyze the published literature on diabetes mellitus and pyroptosis based on a bibliometric approach, so as to provide a comprehensive picture of the hot research directions and dynamic progress in this field. …”
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    Bibliometric and visual analysis of diabetes mellitus and pyroptosis from 2011 to 2022
  18. 24718
    “…Dietary treatments did not affect the hot carcass weight. However, feeding the Finish diet increased (P < 0.05) the iodine value of pork belly samples and decreased (P < 0.05) carcass yield. …”
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    Effects of branched-chain amino acids to lysine ratios in corn distillers dried grains with solubles containing diets on growth performance, plasma nitrogen profile, carcass traits, and economic analysis in growing–finishing pigs
  19. 24719
    “…By design, DMI was greater (P < 0.01) for NON compared to CON on day 46 but was not different (P ≥ 0.41) for the rest of the experiment. While hot carcass weight (423, 428, and 424 ± 7.9 kg for CON, Zn-AA, and NON, respectively) and ribeye area were not different (P ≥ 0.53) due to treatment, marbling score tended (P = 0.06) to be greater in CON compared to Zn-AA. …”
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    Effects of supplemental zinc on growth, carcass characteristics, and liver abscess formation in steers with experimentally induced ruminal acidosis challenge
  20. 24720
    por Meagher, Nicola S., Hamilton, Phineas, Milne, Katy, Thornton, Shelby, Harris, Bronwyn, Weir, Ashley, Alsop, Jennifer, Bisinoto, Christiani, Brenton, James D., Brooks-Wilson, Angela, Chiu, Derek S., Cushing-Haugen, Kara L., Fereday, Sian, Garsed, Dale W., Gayther, Simon A., Gentry-Maharaj, Aleksandra, Gilks, Blake, Jimenez-Linan, Mercedes, Kennedy, Catherine J., Le, Nhu D., Piskorz, Anna M., Riggan, Marjorie J., Shah, Mitul, Singh, Naveena, Talhouk, Aline, Widschwendter, Martin, Bowtell, David D.L., Candido dos Reis, Francisco J., Cook, Linda S., Fortner, Renée T., García, María J., Harris, Holly R., Huntsman, David G., Karnezis, Anthony N., Köbel, Martin, Menon, Usha, Pharoah, Paul D.P., Doherty, Jennifer A., Anglesio, Michael S., Pike, Malcolm C., Pearce, Celeste Leigh, Friedlander, Michael L., DeFazio, Anna, Nelson, Brad H., Ramus, Susan J.
    Publicado 2023
    “…Clustering showed that most MOC (86%) had an immune depleted (cold) phenotype, with only a small proportion (11/76,14%) considered immune inflamed (hot) based on T cell and PD-L1 infiltrates. CONCLUSION. …”
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    Profiling the immune landscape in mucinous ovarian carcinoma
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