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  1. 24761
    “…The n-hexane, ethyl acetate, chloroform, and crude methanolic extracts showed 32.23 ± 0.26, 37.67 ± 1.31, 43.13 ± 0.85, and 46.78 ± 0.9% clot lysis, respectively, whereas the positive control streptokinase showed 93.35 ± 0.35% disruption at the dose of 30,000 I.U. In hot plate method, the highest pain inhibitory activity was found at a dose of 500 mg/kg of crude extract (15.54 ± 0.37 sec) which differed significantly (P <0.01 and P <0.001) with that of the standard drug ketorolac (16.38 ± 0.27 sec). …”
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    In vivo analgesic, antipyretic, and anti-inflammatory potential in Swiss albino mice and in vitro thrombolytic activity of hydroalcoholic extract from Litsea glutinosa leaves
  2. 24762
    “…As a fine-mapping approach, chromosome-wide association mapping targeting a QTL hot-spot on linkage group XIV was performed in the two P. trichocarpa populations. …”
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    High-resolution genetic mapping of allelic variants associated with cell wall chemistry in Populus
  3. 24763
    “…METHODS: Mycelia polysaccharides (MPS) and mycelia zinc polysaccharides (MZPS) of Lentinus edodes SD-08 were extracted by hot water leaching and purified by DEAE-52 cellulose anion-exchange column chromatography separately. …”
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    Purification, characterization and anti-aging capacity of mycelia zinc polysaccharide by Lentinus edodes SD-08
  4. 24764
    “…The frequency of LoF variants differed greatly across the genome, a hot spot with a strikingly high density was observed in a 6 Mb region on BTA18. …”
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    Deep sequencing of Danish Holstein dairy cattle for variant detection and insight into potential loss-of-function variants in protein coding genes
  5. 24765
    “…BACKGROUND: In January of 2014, an outbreak of malaria was declared in the Honde Valley region of Mutasa District in Zimbabwe. The area has a hot, temperate climate and high rainfall pattern ideal for vector breeding and malaria transmission. …”
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    Factors associated with malaria infection in Honde valley, Mutasa district, Zimbabwe, 2014: a case control study
  6. 24766
    “…RESULTS: Male Sema3F KO and wild-type (WT) control mice were subjected to a battery of behavioral tests, including neurological screen, rotarod, hot plate, prepulse inhibition, light/dark transition, open field, elevated plus maze, social interaction, Porsolt forced swim, tail suspension, Barnes maze, and fear conditioning tests. …”
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    Comprehensive behavioral phenotyping of a new Semaphorin 3 F mutant mouse
  7. 24767
    “…Majority of the outbreaks appeared during extremely hot months of April to June. Greenish diarrhoea was frequently seen in birds that survived early in infection. …”
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    Patho-epidemiological study on Genotype-XIII Newcastle disease virus infection in commercial vaccinated layer farms
  8. 24768
    “…CONCLUSION: This study plays a significant role in finding hot spots in P-gp and may offer the further scope of designing potent and specific inhibitors of P-gp. …”
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    In silico Analysis for Predicting Fatty Acids of Black Cumin Oil as Inhibitors of P-Glycoprotein
  9. 24769
    “…Tumors with positive pre-treatment stromal beclin 1 had a higher baseline Ki-67 labeling index (both hot spot and overall average) than those without (p = 0.042 and 0.0075, respectively, N = 53). …”
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    Clinical significance of the expression of autophagy-associated marker, beclin 1, in breast cancer patients who received neoadjuvant endocrine therapy
  10. 24770
    por Kostich, Walter, Hamman, Brian D., Li, Yu-Wen, Naidu, Sreenivasulu, Dandapani, Kumaran, Feng, Jianlin, Easton, Amy, Bourin, Clotilde, Baker, Kevin, Allen, Jason, Savelieva, Katerina, Louis, Justin V., Dokania, Manoj, Elavazhagan, Saravanan, Vattikundala, Pradeep, Sharma, Vivek, Das, Manish Lal, Shankar, Ganesh, Kumar, Anoop, Holenarsipur, Vinay K., Gulianello, Michael, Molski, Ted, Brown, Jeffrey M., Lewis, Martin, Huang, Yanling, Lu, Yifeng, Pieschl, Rick, O’Malley, Kevin, Lippy, Jonathan, Nouraldeen, Amr, Lanthorn, Thomas H., Ye, Guilan, Wilson, Alan, Balakrishnan, Anand, Denton, Rex, Grace, James E., Lentz, Kimberley A., Santone, Kenneth S., Bi, Yingzhi, Main, Alan, Swaffield, Jon, Carson, Ken, Mandlekar, Sandhya, Vikramadithyan, Reeba K., Nara, Susheel J., Dzierba, Carolyn, Bronson, Joanne, Macor, John E., Zaczek, Robert, Westphal, Ryan, Kiss, Laszlo, Bristow, Linda, Conway, Charles M., Zambrowicz, Brian, Albright, Charles F.
    Publicado 2016
    “…One of the lines from this screen, which contained a null allele of the adapter protein-2 associated kinase 1 (AAK1) gene, had a normal response in acute pain assays (hot plate, phase I formalin), but a markedly reduced response to persistent pain in phase II formalin. …”
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    Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain
  11. 24771
    “…The piglet scalding was carried out in hot water bowls, and hair removal by singeing. Animal welfare signs revealed the following aspects: handling: hoisting prior to stunning, vocalizations (41%); stunning: not individual access to box, repeated shocks (4%), mean voltage 135.6 V, mean current for head-only electrical stunning 0.78 A; indicators of not effective stunning: palpebral reflex (24.2%), corneal reflex (12.8%), vocalizations (15.4%); bleeding: conscious and sensitive animal shackling (53.8%). …”
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    Hygiene and Welfare Evaluation of Pigs Slaughtered in Agritourisms
  12. 24772
    “…We analyzed 27 practicable samples using a tumor genotyping panel to assess 23 hot-spot sites of genetic alterations in nine genes (EGFR, KRAS, BRAF, PIK3CA, NRAS, MEK1, AKT1, PTEN, and HER2), gene copy number of EGFR, MET, PIK3CA, FGFR1, and FGFR2, and ALK, ROS1, and RET fusions. …”
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    Frequency of EGFR T790M mutation and multimutational profiles of rebiopsy samples from non-small cell lung cancer developing acquired resistance to EGFR tyrosine kinase inhibitors in Japanese patients
  13. 24773
    “…Higher number of cases occurred in the hot dry season (January through June) and in the central and western part of Ethiopia with 127 lab-confirmed outbreaks in the study period. …”
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    Epidemiology of rubella virus cases in the pre-vaccination era of Ethiopia, 2009–2015
  14. 24774
    “…In late disease, NI men reported significantly higher levels of gynaecomastia (23% vs 9%) and hot flashes(41% vs 19%), but when ADT users were analysed separately, differences disappeared. …”
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    Effect of investigation intensity and treatment differences on prostate cancer survivor's physical symptoms, psychological well-being and health-related quality of life: a two country cross-sectional study
  15. 24775
    “…We show that the 415-gene panel identifies a number of clinically actionable mutations in KRAS, NRAS, and BRAF that are not detected by hot-spot testing. We also discovered that 26% of cases have mutations in genes involved in DNA double-strand break repair pathway. …”
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    Genomic landscape of colorectal cancer in Japan: clinical implications of comprehensive genomic sequencing for precision medicine
  16. 24776
    “…Using cavity ring-down spectroscopy, absolute column densities of CH(X, v = 0), CN(X, v = 0), and NH(X, v = 0) radicals in the hot plasma have been determined as functions of height, z, source gas mixing ratio, total gas pressure, p, and input power, P. …”
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    Microwave Plasma-Activated Chemical Vapor Deposition of Nitrogen-Doped Diamond. II: CH(4)/N(2)/H(2) Plasmas
  17. 24777
    “…The size of each part of the hindbrain and hot cross bun sign (HCBS) in the pons was studied by magnetic resonance imaging. …”
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    Early strong intrathecal inflammation in cerebellar type multiple system atrophy by cerebrospinal fluid cytokine/chemokine profiles: a case control study
  18. 24778
    “…RESULTS: The most common symptoms in Chinese menopausal symptomatic women were “experiencing poor memory” (94.4%), “feeling tired or worn out” (93.8%), “aching in muscle and joints” (89.4%), “low backache” (86.9%), “decrease in physical strength” (86.6%), “aches in back of neck or head” (86.2%), “difficulty sleeping” (83.6%), “accomplishing less than I used to” (83.4%), “feeling a lack of energy” (83.3%), “change in your sexual desire” (81%), and “hot flash” (80.7%) among others. The symptoms of “increased facial hair” were rarely seen (9.9%). …”
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    Psychometric properties of the Chinese version of the Menopause-Specific Quality-of-Life questionnaire
  19. 24779
    “…RESULTS: A total of 608 articles were identified after removal of duplicate entries, of which 63 were found to contain a quantitative estimate of future mortality from hot days or heat waves. A wide range of mortality models and climate model data have been used to estimate future mortality. …”
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    The use of climate information to estimate future mortality from high ambient temperature: A systematic literature review
  20. 24780
    “…The greatest risk of cardiovascular mortality in cold temperature was in the 14 lag days (RR, 1.09; 95% CI [1.07–1.010]) and in hot temperatures in the seven lag days (RR, 1.14; 95% CI [1.09–1.17]). …”
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    Ambient temperature and cardiovascular mortality: a systematic review and meta-analysis
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