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  1. 24801
    “…Implications for prevention include delivering alcohol-related river drowning prevention strategies to both males and females; at peak times including during hot weather, afternoons, public holidays and to river users who swim. …”
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    Breathalysing and surveying river users in Australia to understand alcohol consumption and attitudes toward drowning risk
  2. 24802
    “…Resistance of M. tuberculosis to rifampicin is mainly due to mutations in hot-spot region of rpoB gene (HSR-rpoB). The prevalence of disputed (generally missed by rapid phenotypic DST methods) rpoB mutations, which mainly include L511P, D516Y, H526N, H526L, H526S, and L533P in HSR-rpoB and I572F in cluster II region of rpoB gene, is largely unknown. …”
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    Occurrence of disputed rpoB mutations among Mycobacterium tuberculosis isolates phenotypically susceptible to rifampicin in a country with a low incidence of multidrug-resistant tuberculosis
  3. 24803
    “…Members of the genus Exiguobacterium are found in diverse environments from marine, freshwaters, permafrost to hot springs. Exiguobacterium can grow in a wide range of temperature, pH, salinity, and heavy-metal concentrations. …”
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    The Complete Genome and Physiological Analysis of the Eurythermal Firmicute Exiguobacterium chiriqhucha Strain RW2 Isolated From a Freshwater Microbialite, Widely Adaptable to Broad Thermal, pH, and Salinity Ranges
  4. 24804
    “…All patients were assessed preoperatively and postoperatively using 4 PRO measures: the modified Harris Hip Score (mHHS), Non-Arthritic Hip Score (NAHS), Hip Outcome Score–Sport-Specific Subscale (HOS-SSS), and International Hip Outcome Tool–12 (iHOT-12). Pain was estimated using a visual analog scale. …”
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    Effect of Cigarette Smoking on Patient-Reported Outcomes in Hip Arthroscopic Surgery: A Matched-Pair Controlled Study With a Minimum 2-Year Follow-up
  5. 24805
    por Mousa, Shaker A., Ayoub, Bassam M.
    Publicado 2019
    “…Drug repositioning is a hot topic as an alternative to molecular target based drug discovery or therapeutic switching. …”
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    Repositioning of dipeptidyl peptidase-4 inhibitors and glucagon like peptide-1 agonists as potential neuroprotective agents
  6. 24806
    por He, Yi, Cao, Luying, Yu, Jialin
    Publicado 2018
    “…BACKGROUND: Currently, prophylactic use of drugs to promote a healthy gut microbiota and immune system in preterm infants is hot debated, among which lactoferrin is a promising supplementation. …”
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    Prophylactic lactoferrin for preventing late-onset sepsis and necrotizing enterocolitis in preterm infants: A PRISMA-compliant systematic review and meta-analysis
  7. 24807
    “…In order to be feasible for low and middle income countries (LMICs), any process to create or formulate such a therapeutic must be inexpensive at scale, and the resulting formulation must survive without refrigeration even in hot, humid climates. We here demonstrate the scalability and stability of a nanoparticle (NP) formulation of OZ439. …”
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    Spray drying OZ439 nanoparticles to form stable, water-dispersible powders for oral malaria therapy
  8. 24808
    “…METHODS: The antinociceptive potential of orally administered PECN (100, 250, 500 mg/kg) was studied using the abdominal constriction-, hot plate- and formalin-induced paw licking-test in mice (n = 6). …”
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    Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway
  9. 24809
    “…On the other hand, Bhagnari and Tharparkar being popular for their adaptation to dry and extremely hot climates were found to share the highest number of SNPs. …”
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    Genomic variants identified from whole-genome resequencing of indicine cattle breeds from Pakistan
  10. 24810
    “…Thus, multiplex PCR-based sequencing is most commonly applied in routine molecular testing, which is predominantly focused on the identification of known hot spot mutations in oncogenes. METHODS: We compared the overall performance of an adjusted targeted capture-based enrichment protocol and a multiplex PCR-based approach for calling of pathogenic SNVs and InDels using DNA extracted from 13 FFPE tissue samples. …”
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    Targeted capture-based NGS is superior to multiplex PCR-based NGS for hereditary BRCA1 and BRCA2 gene analysis in FFPE tumor samples
  11. 24811
    “…Based on the conservative feature, two rounds of consecutive evolution were performed targeting the hot region of P(srfA). In the first round, a primary promoter mutation library (pPML) was constructed by mutagenesis targeting the 3-bp sequence immediately upstream of the − 10 box of the P(srfA). …”
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    Development of a novel strategy for robust synthetic bacterial promoters based on a stepwise evolution targeting the spacer region of the core promoter in Bacillus subtilis
  12. 24812
    “…Clinical case: a 27-year-old woman was referred with a 2-year history of hypertensive crisis, headache, tachycardia, diaphoresis, hot flushes, dyspnea, chest pain, weight loss, and polyuria. …”
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    SAT-321 Bilateral Cortical Sparing Adrenalectomy For Treatment Of Pheochromocytoma In A MEN2-a Mutation Carrier: 19 Year Follow-up
  13. 24813
    “…Malaria prevalence was highest (42.9%) in children of 10–15 years of age, and significantly low during dry and hot season. Of the infected individuals, 78.1% were from rice-irrigation, 18.7% savannah and 3.2% sugarcane ecosystem. …”
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    Spatio-temporal prevalence of malaria and anaemia in relation to agro-ecosystems in Mvomero district, Tanzania
  14. 24814
    “…These regions of escalated dose within the target may increase tumor control probability (TCP). Purposely embedding hot spots within tumors during optimization may also increase the TCP. …”
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    Radiation treatment planning with embedded dose escalation
  15. 24815
    “…METHODS: Lignosus rhinocerotis, Pleurotus giganteus, Hericium erinaceus, Schizophyllum commune and Ganoderma lucidium were selected for evaluation of their in-vitro anti-dengue virus serotype 2 (DENV-2) activities. Hot aqueous extracts (HAEs), ethanol extracts (EEs), hexane soluble extracts (HSEs), ethyl acetate soluble extracts (ESEs) and aqueous soluble extracts (ASEs) were prepared from the selected mushrooms. …”
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    Anti-viral activity of culinary and medicinal mushroom extracts against dengue virus serotype 2: an in-vitro study
  16. 24816
    “…The pathogenic mutations of c.1031A > G in ACADS, c.449_452delCTGA in ACADM and c.1349G > A in ACADL were found to be hot spots in Suzhou patients with SCAD, MCAD, and VLCAD, respectively. …”
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    New Ratios for Performance Improvement for Identifying Acyl-CoA Dehydrogenase Deficiencies in Expanded Newborn Screening: A Retrospective Study
  17. 24817
    “…Follow-up PET-CT confirmed good resolution of previous hot spots (mean SUVmax −4.5) except for the patient who did not tolerate RFB 300 due to fever and nausea on the first re-challenge, whose PET-CT detected a slight increase in mean SUVmax +0.6 and was hospitalized for dry cough on daily AZR–ciprofloxacin. …”
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    1360. Disseminated Mycobacterium abscessus Infections in Patients with Neutralizing Anti-interferon-gamma Autoantibodies Treated with Rifabutin-based Combination Regimens
  18. 24818
    “…Isolates displaying echinocandin MIC>ECV were sequenced for fks hot spot (HS) mutations. RESULTS: RZF inhibited 99.7% of C. albicans (CA) isolates (MIC(50/90), 0.015/0.06 mg/L), 100.0% of C. tropicalis (CT) (MIC(50/90), 0.03/0.06 mg/L), 98.9% of C. glabrata (CG) (MIC(50/90), 0.03/0.06 mg/L), 100.0% of C. krusei (CK) (MIC(50/90), 0.015/0.12 mg/L), and 100.0% of C. dubliniensis (CD) (MIC(50/90), 0.03/0.06 mg/L) at ≤0.12 mg/L. …”
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    2115. Activity of a Long-Acting Echinocandin Rezafungin and Comparator Antifungal Agents Tested against Contemporary Invasive Fungal Isolates: SENTRY 2018
  19. 24819
    “…For this reason, the development of novel mutations in ALS (Os02g30630) to generate rice plants more tolerant to Imidazolinones than the available mutant rice lines is still a hot topic in plant-herbicide interaction field. …”
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    Push It to the Limit: Identification of Novel Amino Acid Changes on the Acetolactate Synthase Enzyme of Rice That Putatively Confer High Level of Tolerance to Different Imidazolinones
  20. 24820
    “…BACKGROUND: In the Republic of Congo, hot temperature and seasons distortions observed may impact the development of malaria parasites. …”
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    Variation of prevalence of malaria, parasite density and the multiplicity of Plasmodium falciparum infection throughout the year at three different health centers in Brazzaville, Republic of Congo
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