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25081“…At 18 years, she used OCPs for few months, and used plan B, after which her menses stopped. She had hot flashes and sweating. She was placed on progesterone, but never had withdrawal bleeding. …”
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25082por Manfrini, Elia, Smits, Marion, Thust, Steffi, Geiger, Sergej, Bendella, Zeynep, Petr, Jan, Solymosi, Laszlo, Keil, Vera C.“…OBJECTIVE: Quantitative MRI (qMRI) methods provide versatile neuroradiological applications and are a hot topic in research. The degree of their clinical implementation is however barely known. …”
Publicado 2021
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25083por Meiller, Clément, Montagne, François, Hirsch, Theo Z., Caruso, Stefano, de Wolf, Julien, Bayard, Quentin, Assié, Jean-Baptiste, Meunier, Léa, Blum, Yuna, Quetel, Lisa, Gibault, Laure, Pintilie, Ecaterina, Badoual, Cécile, Humez, Sarah, Galateau-Sallé, Françoise, Copin, Marie-Christine, Letouzé, Eric, Scherpereel, Arnaud, Zucman-Rossi, Jessica, Le Pimpec-Barthes, Françoise, Jaurand, Marie-Claude, Jean, Didier“…Finally, significant changes in the expression of immune mediators and genes related to immunological synapse, as well as differential infiltration of immune populations in the tumor environment, were observed and led to a switch from a hot to a cold immune profile in three patients. …”
Publicado 2021
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25084por Höhn, Julia, Hekler, Achim, Krieghoff-Henning, Eva, Kather, Jakob Nikolas, Utikal, Jochen Sven, Meier, Friedegund, Gellrich, Frank Friedrich, Hauschild, Axel, French, Lars, Schlager, Justin Gabriel, Ghoreschi, Kamran, Wilhelm, Tabea, Kutzner, Heinz, Heppt, Markus, Haferkamp, Sebastian, Sondermann, Wiebke, Schadendorf, Dirk, Schilling, Bastian, Maron, Roman C, Schmitt, Max, Jutzi, Tanja, Fröhling, Stefan, Lipka, Daniel B, Brinker, Titus Josef“…The patient data were mostly one-hot encoded. There were differences in the complexity that the encoded patient data were processed with regarding deep learning methods before and after fusing them with the image features for a combined classifier. …”
Publicado 2021
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25085por Vo, Thu Thi Minh, Nguyen, Tuan Viet, Amoroso, Gianluca, Ventura, Tomer, Elizur, Abigail“…In Tasmania, flesh color depletion can noticeably affect farmed Atlantic salmon at different levels of severity following extremely hot summers. In this study, RNA sequencing (RNA-Seq) was performed to investigate the reduction in flesh pigmentation. …”
Publicado 2021
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25086“…The average reduction in D(99%) was 2.1% for −20% error and 2.8% for +20% error. The hot spot evaluation showed that, for the same magnitude of error, the decreasing spot sizes resulted in a positive difference (hotter plan) when compared with the increasing spot sizes. …”
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25087por Messersmith, Elizabeth M, Niedermayer, Emma K, Thornton, Kara J, Crawford, Grant I, Hansen, Stephanie L“…No effects of Zn, IMP, or the interaction were observed for carcass-adjusted gain to feed, days 0–168 DM intake, hot carcass weight, or ribeye area (P ≥ 0.11). The nominal differences in performance between implant strategies suggest that extended-release implants may be an effective implant strategy to replace re-implant programs in heifers, whereas the improved performance of heifers fed IND vs. …”
Publicado 2021
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25088por Rigueiro, André L. N., Squizatti, Mariana M., Silvestre, Antonio M., Pinto, Ana C. J., Estevam, Daniela D., Felizari, Luana D., Dias, Evandro F. F., Demartini, Breno L., Nunes, Ana B. P. C., Costa, Victor C. M., Caixeta, Eduardo L., Santi, Pedro F., Soares, Carlos H. G., Arrigoni, Mario D. B., Millen, Danilo D.“…No effects of treatments were observed (P < 0.10) for final body weight, average daily gain (ADG), and hot carcass weight (HCW). Cattle fed VM14 presented a greater (P ≤ 0.03) DMI, expressed as percent of body weight (BW), than animals fed either MON14 or MONVM14; however, cattle fed either MON14 or MONVM14 improved (P ≤ 0.02) the gain-to-feed ratio (G/F) by 10.4 or 8.1%, respectively, when compared to bulls fed VM14. …”
Publicado 2021
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25089por Ou, Junxian, Zhou, Zhonghua, Dai, Ruixue, Zhang, Jing, Zhao, Shan, Wu, Xiaowei, Lan, Wendong, Ren, Yi, Cui, Lilian, Lan, Qiaoshuai, Lu, Lu, Seto, Donald, Chodosh, James, Wu, Jianguo, Zhang, Gong, Zhang, Qiwei“…Thus, whether mutations in the RBD of the circulating SARS-CoV-2 isolates have altered the receptor binding affinity and made them more infectious has been the research hot spot. Given that SARS-CoV-2 is a novel coronavirus, the significance of our research is in identifying and validating the RBD mutant types emerging during the early transmission phase and increasing human angiotensin-converting enzyme 2 (ACE2) receptor binding affinity and infectivity. …”
Publicado 2021
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25090“…BACKGROUND: As a hot method in machine learning field, the forests approach is an attractive alternative approach to Cox model. …”
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25091por Dube, Kushupika, Lavender, Tina, Blaikie, Kieran, Sutton, Christopher J., Heazell, Alexander E. P., Smyth, Rebecca M. D.“…Mild aOR 14.29, 95% CI 3.09 to 66.08; Hot season vs. Mild aOR 3.39, 95% CI 0.86 to 13.27). …”
Publicado 2021
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25092Identification and clinical significance of somatic oncogenic mutations in epithelial ovarian cancerpor Watanabe, Takafumi, Nanamiya, Hideaki, Endo, Yuta, Kojima, Manabu, Nomura, Shinji, Furukawa, Shigenori, Soeda, Shu, Tamura, Hirosumi, Ryufuku, Masae, Tanaka, Daisuke, Isogai, Takao, Imai, Jun-ichi, Watanabe, Shinya, Fujimori, Keiya“…We investigated mutational status in hot spot regions of 50 cancer-related genes by targeted next-generation sequencing using an Ion AmpliSeq Cancer Hotspot Panel v2 Kit. …”
Publicado 2021
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25093por Xuan, Biao, Park, Jongbin, Choi, Sukjung, You, Inhwan, Nam, Bo-Hye, Noh, Eun Soo, Kim, Eun Mi, Song, Mi-Young, Shin, Younhee, Jeon, Ji-Hyeon, Kim, Eun Bae“…Because of its high susceptibility to abnormal water temperature from global warming, a large number of smelt die in hot summers. Here, we present the first draft genome of H. nipponensis and transcriptomic changes in molecular mechanisms or intracellular responses under heat stress. …”
Publicado 2021
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25094por Yang, Tzu-Hsien, Shiue, Sheng-Cian, Chen, Kuan-Yu, Tseng, Yan-Yuan, Wu, Wei-Sheng“…In the devised deep network, the given piRNA and mRNA segment sequences are first one-hot encoded and undergo a combined operation of convolution and squeezing-extraction to unravel motif patterns. …”
Publicado 2021
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25095por Li, Chuang, Zhu, Lijuan, Fu, Lijun, Han, Mingli, Li, Ya, Meng, Zhaozhong, Qiu, Xinguang“…BACKGROUND: Circular RNAs (circRNAs) have become a hot topic in the area of tumor biology due to its closed structure and the post-transcriptional regulatory effect. …”
Publicado 2021
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25096por Rich, Patricia, Mitchell, R Brian, Schaefer, Eric, Walker, Paul R, Dubay, John W, Boyd, Jason, Oubre, David, Page, Ray, Khalil, Mazen, Sinha, Suman, Boniol, Scott, Halawani, Hafez, Santos, Edgardo S, Brenner, Warren, Orsini, James M, Pauli, Emily, Goldberg, Jonathan, Veatch, Andrea, Haut, Mitchell, Ghabach, Bassam, Bidyasar, Savita, Quejada, Maria, Khan, Waseemullah, Huang, Kan, Traylor, Linda, Akerley, Wallace“…After enrolment and prior to therapy initiation, all patients are tested and designated HIC-Hot (HIC-H) or HIC-Cold (HIC-C). A prespecified interim analysis was performed after 1-year follow-up with the first 2000 enrolled patients. …”
Publicado 2021
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25097por Li, Jingjing, Wu, Xinxin, Mao, Ning, Zheng, Guibin, Zhang, Haicheng, Mou, Yakui, Jia, Chuanliang, Mi, Jia, Song, Xicheng“…METHODS: In this retrospective study, 678 patients with PTC were enrolled from Yantai Yuhuangding Hot3spital (n=605) and the Affiliated Hospital of Binzhou Medical University (n=73) within August 2010 to December 2020. …”
Publicado 2021
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25098por Racinais, Sebastien, Ihsan, Mohammed, Taylor, Lee, Cardinale, Marco, Adami, Paolo Emilio, Alonso, Juan Manuel, Bouscaren, Nicolas, Buitrago, Sebastian, Esh, Chris J, Gomez-Ezeiza, Josu, Garrandes, Frederic, Havenith, George, Labidi, Mariem, Lange, Gunter, Lloyd, Alexander, Moussay, Sebastien, Mtibaa, Khouloud, Townsend, Nathan, Wilson, Mathew G, Bermon, Stephane“…PURPOSE: To characterise hydration, cooling, body mass loss, and core (T(core)) and skin (T(sk)) temperatures during World Athletics Championships in hot-humid conditions. METHODS: Marathon and race-walk (20 km and 50 km) athletes (n=83, 36 women) completed a pre-race questionnaire. …”
Publicado 2021
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25099por Zinszer, Kate, McKinnon, Britt, Bourque, Noémie, Pierce, Laura, Saucier, Adrien, Otis, Alexandra, Cheriet, Islem, Papenburg, Jesse, Hamelin, Marie-Ève, Charland, Katia, Carbonneau, Julie, Zahreddine, Monica, Savard, Ashley, Fortin, Geneviève, Apostolatos, Alexander, Haley, Nancy, Ratté, Nathalie, Laurin, Isabel, Nguyen, Cat Tuong, Conrod, Patrica, Boivin, Guy, De Serres, Gaston, Quach, Caroline“…IMPORTANCE: Quebec prioritized in-person learning after the first wave of the COVID-19 pandemic, with school closures being implemented temporarily in selected schools or in hot-spot areas. Quebec’s decision to keep most schools open was controversial, especially in Montreal, which was the epicenter of Canada’s first and second waves; therefore, understanding the extent to which children were infected with SARS-CoV-2 provides important information for decisions about school closures. …”
Publicado 2021
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25100por Kabir, Kourosh, Taherinia, Ali, Ashourloo, Davoud, Khosravi, Ahmad, Karim, Hossien, Salehi Shahrabi, Hamid, Hedayat Yaghoobi, Mojtaba, Soleimani, Alireza, Siami, Zaynab, Noorisepehr, Mohammad, Tajbakhsh, Ramin, Maghsoudi, Mohammad Reza, Lak, Mehran, Mardi, Parham, Nouri, Behnaz, Mohammadzadeh, Mohammad, Azimzadeh, Mehdi, Bakhtiyari, Mahmood“…Seven days average of cases, deaths, doubling times and CFRs used to draw smooth charts. kernel density tool in Arc GIS (Esri) software has been employed to compute hot spot area of the study site. RESULTS: The maximum-likelihood value of R0 was 2.88 (95%, CI: 2.57–3.23) in the early 14 days of epidemic. …”
Publicado 2021
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