“…Immunoisolation of these cells via microencapsulation is a hotly investigated field, and the preferred material of choice has been alginate, a natural polymer derived from seaweed due to its gelling conditions. …”
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“…However, due to a paucity of randomized controlled trials, its timing is controversial and a hotly debated topic. This article reviews some of the main controversies surrounding the surgical management of colorectal cancer liver metastases (CRLM). …”
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“…The impact of increasing numbers of lawsuits for access to medicines in Brazil is hotly debated. Government officials and scholars assert that the “judicialization of health” is driven by urban elites and private interests, and is used primarily to access high-cost drugs. …”
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“…We review the major questions and controversies that have preoccupied population geneticists during this time (and were often hotly debated at PGG meetings). We show how theoretical and empirical work has combined to generate a highly productive interaction involving successive developments in the ability to characterise variability at the molecular level, to apply mathematical models to the interpretation of the data and to use the results to answer biologically important questions, even in nonmodel organisms. …”
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“…The potential for oilfield activities to trigger earthquakes in seismogenic areas has been hotly debated. Our model compares the stress changes from remote water injection and a natural earthquake, both of which occurred in northern Italy in recent years, and their potential effects on a nearby Mw 5.9 earthquake that occurred in 2012. …”
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“…Our findings suggest that population contact may have played a crucial role in the evolution of hominin cultures and propose explanations for observations of Palaeolithic cultural change whose interpretations have been hotly debated.…”
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“…The significance of, and therefore treatment of, these and other such bony defects around the shoulder joint has been hotly debated. METHODS: We reviewed the available current literature to determine and report on the most up to date concepts and treatment techniques being used to manage bony defects of the shoulder. …”
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“…However, the mechanisms of persistence are hotly debated, necessitating the development of multiple mechanistic models. …”
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“…The origin of human speech is still a hotly debated topic in science. Evidence of socially-guided acoustic flexibility and proto-conversational rules has been found in several monkey species, but is lacking in social and cooperative great apes. …”
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“…The number of news sources consumed, in turn, was seen as inverse proxy for the susceptibility to be caught in “filter bubbles” and/or “echo chambers” (online), which are hotly discussed topics also in politics. A sample of 1,681 (n = 557 males) participants provided data on demographics, the Big Five as well as Right-Wing Authoritarianism (RWA) alongside the number of different news sources consumed and current voting preferences. …”
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“…Proximate control of the development of sexual dimorphism is still hotly debated in reptiles. In some squamates, many male-typical exaggerated traits including body size were assumed to be controlled by masculinization by male gonadal androgens. …”
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“…The early peopling of the Americas has been one of the most hotly contested topics in American anthropology and a research issue that draws archaeologists into a multidisciplinary debate. …”
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“…Currently, sphingolipids and their metabolism are hotly debated topics in various biochemical fields. …”
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“…Type I and Type III TA systems are unique in that the antitoxin in these systems is an RNA molecule, whereas the antitoxin in all other TA systems is a protein. Though hotly debated, the involvement of TA systems in bacterial physiology is recognized by several studies, with the Type II TA system being the most extensively studied to date. …”
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“…One such procedure is Medical Assistance in Dying (MAiD), and it is hotly contended in many spheres of society. From legal to personal perspectives, there are strong arguments for its implementation and prohibition. …”
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“…The identity of the transport proteins responsible for sustaining Mg(2+) levels in eukaryotic cells remains hotly debated, and several are restricted to specific groups of higher eukaryotes. …”
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“…Explainability for artificial intelligence (AI) in medicine is a hotly debated topic. Our paper presents a review of the key arguments in favor and against explainability for AI-powered Clinical Decision Support System (CDSS) applied to a concrete use case, namely an AI-powered CDSS currently used in the emergency call setting to identify patients with life-threatening cardiac arrest. …”
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“…Methanogenesis has been widely accepted as an ancient metabolism, but the precise evolutionary trajectory remains hotly debated. Disparate theories exist regarding its emergence time, ancestral form, and relationship with homologous metabolisms. …”
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“…Climate change is one of the most hotly debated issues of today. Increasing global temperatures will impact all of us. …”
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“…Finally, we explore the option of subsuming exceptionally contrast-preserving borrowed verbs under denominal verbs, offering arguments in favor of the hotly debated view from the literature that verbs are universally borrowed as denominal.…”
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