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  1. 25681
    “…In particular, the usefulness of cosyntropin stimulation and benefit of superselective adrenal vein catheterization have been hotly debated. OBJECTIVE: We report a case that highlights the potential pitfalls of superselective sampling and demonstrates a negligible effect of cosyntropin stimulation on aldosterone secretion in nonadenomatous adrenal tissue when an aldosterone-producing adenoma (APA) is present. …”
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    A Case of Adrenal Vein Sampling in Primary Aldosteronism With Homolateral Suppression
  2. 25682
    por Mor-Shaked, Hagar, Eiges, Rachel
    Publicado 2018
    “…The timing of FMR1 hypermethylation and transcription silencing is still hotly debated. There is evidence that hypermethylation varies considerably between and within the tissues of patients as well as during fetal development, thus supporting the view that FMR1 silencing is a post-zygotic event that is developmentally structured. …”
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    Reevaluation of FMR1 Hypermethylation Timing in Fragile X Syndrome
  3. 25683
    “…BACKGROUND: Although horizontal gene transfer (HGT) is a widely accepted force in the evolution of prokaryotic genomes, its role in the evolution of eukaryotic genomes remains hotly debated. Some bdelloid rotifers that are resistant to extreme desiccation and radiation undergo a very high level of HGT, whereas in another desiccation-resistant invertebrate, the tardigrade, the pattern does not exist. …”
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    Desiccation does not drastically increase the accessibility of exogenous DNA to nuclear genomes: evidence from the frequency of endosymbiotic DNA transfer
  4. 25684
    “…The life appearance of dinosaurs is a hotly debated topic in the world of paleontology, especially when it comes to dinosaur integument. …”
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    Evidence of integumentary scale diversity in the late Jurassic Sauropod Diplodocus sp. from the Mother’s Day Quarry, Montana
  5. 25685
    “…The electronic and geometric structures of the water‐oxidizing complex of photosystem II in the steps of the catalytic cycle that precede dioxygen evolution remain hotly debated. Recent structural and spectroscopic investigations support contradictory redox formulations for the active‐site Mn(4)CaO( x ) cofactor in the final metastable S(3) state. …”
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    Redox Isomerism in the S(3) State of the Oxygen‐Evolving Complex Resolved by Coupled Cluster Theory
  6. 25686
    “…Regarding the embodiment of language processing in adults, there is evidence of a close connection between sensorimotor brain areas and brain areas relevant to the processing of action verbs. This thesis is hotly debated and has therefore been thoroughly studied in adults. …”
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    Abstract Action Language Processing in Eleven-Year-Old Children: Influence of Upper Limb Movement on Sentence Comprehension
  7. 25687
    “…The extent to which developmental bias, the tendency of certain phenotypes to preferentially appear as potential variation, also explains these patterns is hotly debated. Here we demonstrate quantitatively that developmental bias is the primary explanation for the occupation of the morphospace of RNA secondary structure (SS) shapes. …”
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    Phenotype Bias Determines How Natural RNA Structures Occupy the Morphospace of All Possible Shapes
  8. 25688
    “…Whether there is requirement of booster dose and whether the impending wave could affect the children are some of the hotly debated topics. MATERIALS AND METHODS: A systematic literature review of PubMed, Medline, Scopus, Google Scholar was utilized to understand the nature of Delta variant and how it alters our T-cell responses and cytokine production and neutralizes vaccine-generated antibodies. …”
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    COVID-19 pandemic: the delta variant, T-cell responses, and the efficacy of developing vaccines
  9. 25689
    “…Yet, how pitch and harmony affect our emotions, and to what extent these effects are culturally mediated or universal, is hotly debated [2, 5, 14–20]. Here, we report an experiment conducted in a remote cloud forest region of Papua New Guinea, across several communities with similar traditional music but differing levels of exposure to Western-influenced tonal music. …”
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    Emotional responses in Papua New Guinea show negligible evidence for a universal effect of major versus minor music
  10. 25690
    “…Definitions of autism are constantly in flux and the validity and utility of diagnostic criteria remain hotly debated. The boundaries of autism are unclear and there is considerable heterogeneity within autistic individuals. …”
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    Autism: A model of neurodevelopmental diversity informed by genomics
  11. 25691
    “…While it is generally agreed that DJ-1 is able to metabolize methylglyoxal to lactate, the mechanism by which it does so is hotly debated with potential implications for cellular function. …”
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    PARK7 Catalyzes Stereospecific Detoxification of Methylglyoxal Consistent with Glyoxalase and Not Deglycase Function
  12. 25692
    “…The theory of inosculation (that skin grafts subsequently obtain nourishment via blood vessel “anastomosis” between new vessels invading from the wound bed and existing graft vessels) was hotly debated from the late 19th to mid-20th century. …”
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    Real-Time Demonstration of Split Skin Graft Inosculation and Integra Dermal Matrix Neovascularization Using Confocal Laser Scanning Microscopy
  13. 25693
    “…However, the clinical relevance of cellular membrane accumulation by antidepressants in the human brain is unknown and hotly debated. Here we take a novel, evolutionarily informed approach to studying the effects of the selective-serotonin reuptake inhibitor sertraline/Zoloft® on cell physiology in the model eukaryote Saccharomyces cerevisiae (budding yeast), which lacks a serotonin transporter entirely. …”
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    Accumulation of an Antidepressant in Vesiculogenic Membranes of Yeast Cells Triggers Autophagy
  14. 25694
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    On the Pitch Strength of Bandpass Noise in Normal-Hearing and Hearing-Impaired Listeners
  15. 25695
    “…Goal-directed therapy based on brain-oxygen saturation (bSo(2)) is controversial and hotly debated. While meta-analyses of aggregated data have shown no clinical benefit for brain near-infrared spectroscopy (NIRS)-based interventions after cardiac surgery, no network meta-analyses involving both major cardiac and noncardiac procedures have yet been undertaken. …”
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    Near-Infrared Spectroscopy Monitoring in Cardiac and Noncardiac Surgery: Pairwise and Network Meta-Analyses
  16. 25696
    “…Although the first five gun mutants were identified 30 years ago, the functions of GUN proteins in retrograde signaling remain controversial, and that of GUN1 is hotly disputed. Here, we provide background information and critically discuss recently proposed concepts that address GUN-related signaling and some novel gun mutants. …”
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    Retrograde signaling in plants: A critical review focusing on the GUN pathway and beyond
  17. 25697
    por Chalmers, David J
    Publicado 1997
    “…These questions today are among the most hotly debated issues among scientists and philosophers, and we have seen in recent years superb volumes by such eminent figures as Francis Crick, Daniel C. …”
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    The conscious mind: in search of a fundamental theory
  18. 25698
    “…The timely detection of cognitive impairment is clinically important, however the use of cognitive assessments in adult audiology services is a hotly debated topic. Although the early detection of cognitive impairment may improve patient care and quality of life, patients attending audiology services for hearing assessment might not expect to be asked questions about their cognition. …”
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    Patient perceptions of cognitive screening in adult audiology services: A qualitative exploration
  19. 25699
    “…Reconstruction of the placental mammalian (eutherian) evolutionary tree has undergone diverse revisions, and numerous aspects remain hotly debated. Initial hierarchical divisions based on morphology contained many misgroupings due to features that evolved independently by similar selection processes. …”
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    Retroposed Elements as Archives for the Evolutionary History of Placental Mammals
  20. 25700
    “…They were asked to evaluate the products based on appearance (smell, colour, humidity, grind size, ease of preparation and overall appearance) and smoking characteristics (burn rate, hotness, harshness and taste). Five-point Likert scores were assigned to each characteristic. …”
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    Evaluation of herbal cannabis characteristics by medical users: a randomized trial
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