“…Self-compassion involves being kind to oneself when failing, perceiving one’s inadequacies as part of the human condition, and being mindful about negative aspects of oneself. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Two mouse models of this syndrome, with hemizygous deletion of the orthologous region in the murine genome, have recently been shown to recapitulate a number of the behavioral and physiological deficits that characterize the human condition. Still, little is known of the underlying biological mechanisms. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, finding a model that precisely mimics the human condition can be challenging and expensive. Whilst cellular and invertebrate models are frequently used in neurodegenerative research and have undoubtedly yielded much useful data, the comparatively simplistic nature of these systems makes insights gained from such a stand alone model limited when it comes to translation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In so much as is possible, a good model would exhibit as many behavioral, anatomical, biochemical, immunological, and pathological changes as are observed in the human condition, developing progressively, with clear, identifiable biomarkers along the way. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…All pose challenges to human health gains, leading to the concept of planetary health—that the human condition is tied to natural systems. The Planetary Health Commission report highlights several major concerns arising from environmental change including impacts on food availability and quality, increases in natural disasters and population displacement, and newly emerging diseases, e.g. from zoonotic infections. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Although no animal model perfectly mimics the human condition, this genetic large‐animal model is a novel tool for testing therapeutic interventions in the context of developing and advanced coronary artery disease.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: NEC is a severe form of intestinal inflammation in preterm neonates and current models do not reproduce the human condition. METHODS: Three groups of newborn piglets: Formula alone (FO), Bacteria alone (E.coli: BO) and E.coli-fermented formula (FF) were anesthetized, instrumented and underwent post-pyloric injection of formula, bacteria or fermented-formula. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…OBJECTIVE: To validate TS-MS methods using specimens from naturally-occurring InvUC in dogs where the cancer closely mimics the human condition, and to demonstrate proof-of-concept that TS-MS can elucidate lipid patterns distinguishing InvUC from normal urothelium. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mortality is an obvious if uncomfortable part of the human condition, yet it is impossible to study its impact on anyone who experiences it. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A fundamental question is whether neuronal phenotypes caused by the mutation of Cyfip1 are relevant for the human condition. Here, we describe a synaptic cluster of ASD-associated proteins centered on CYFIP1 and the adhesion protein Neuroligin-3. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Behaviours are seen that could be consistent with pre-diagnosis changes in the human condition. FUNDING: GlaxoSmithKline; BBSRC; UCL; ARUK; MRC.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A validated animal model is needed to bridge the translational gap to the clinic and should mimic the human condition. Introducing a standardized method, we comprehensively and reliably characterize the SB phenotype in two lamb surgical models with and without myelotomy as compared to normal lambs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Taken together, the inclusion of hematological measures in mouse models of emerging viral pathogenesis increases their translatability and should elevate the preclinical evaluation of MERS-CoV therapeutics and vaccines to better mirror the complexity of the human condition.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Patient-derived xenografts (PDXs) provide an opportunity to evaluate the effects of therapies in an environment that more closely resembles the human condition than that seen with long-term passage cell lines. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Continuous oral administration of corticosterone (CORT) to pregnant mice throughout the second half of pregnancy resulted in an ~2-fold increase in circulating hormone in dams with no concomitant increase in fetal circulation, similar to the human condition. To determine how prolonged heightened stress hormone affected allergic immunity in offspring, we induced allergic asthma with house dust mite (HDM) and examined the airway immune response to allergen. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Understanding this early plasticity presents additional opportunities for intervention to reduce or eliminate tinnitus from the human condition.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These findings are consistent with human COVID-19 further demonstrating that the AGM faithfully reproduces the human condition.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Dams immunized with the extracellular portion of Caspr2 express anti-Caspr2 antibodies throughout gestation to better mimic the human condition. Male but not female mice born to dams harboring polyclonal anti-Caspr2 antibodies showed abnormal cortical development, decreased dendritic complexity of excitatory neurons and reduced numbers of inhibitory neurons in the hippocampus, as well as repetitive behaviors and impairments in novelty interest in the social preference test as adults. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Using a murine model we previously identified that HCM causing cardiac troponin I mutation Gly203Ser (cTnI-G203S) is associated with increased mitochondrial metabolic activity, consistent with the human condition. These alterations precede development of the cardiomyopathy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The Summit brought forward an understanding of climate change as a symptom of a much larger problem with how colonialism has altered the human condition. The Knowledge Keepers suggested that, in order to effectively address climate change, humanity needs a shift in values and behaviours that ground our collective existence in a balanced relationship with the natural world and its laws. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso