“…OBJECTIVES: We aimed to assess sex-specific differences in the expression of inflammatory and fibrotic genes, as well as in cholesterol metabolism, focusing on the expression of Pcsk9 in several tissues in a mouse model of NASH that shows the typical features of the human condition. METHODS AND RESULTS: We fed 10-months-old male and female C57Bl/6J mice with a NASH-inducing CDAA or corresponding control diet for 8 weeks. …”
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“…Although the search for language rudiments in the communications of primates long predates the vervet alarm call story, it is difficult to overstate the impact of the vervet research, for it fueled field and laboratory research programs for several generations of primatologists and kept busy an equal number of philosophers, linguists, and cognitive scientists debating possible implications for the origins and evolution of language and other vaunted elements of the human condition. Now 40-years on, the original vervet alarm call findings have been revised and claims of semanticity recanted; while other evidence for semantics and syntax in the natural communications of non-humans is sparse and weak. …”
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“…Given several limitations, extrapolation of the animal data to the human condition is tenuous.…”
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“…In the behavioral data, we found an increased velocity and positional error of the ball from the track in the human-human condition vs. human-robot condition. For the EEG data, we computed event-related potentials. …”
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“…An integrated object-oriented perspective calls attention to the human condition as a product of millennial-scale human–thing co-adaptation, in the course of which hominins, artefacts and technologies continuously influenced and co-created each other.…”
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“…Although high levels of TDP-43 overexpression have been modeled in mice and shown to cause early death, models with low-level overexpression that mimic the human condition have not been established. In this study, transgenic mice overexpressing wild type TDP-43 at less than 60% above the endogenous CNS levels were constructed, and their phenotypes analyzed by a variety of techniques, including biochemical, molecular, histological, behavioral techniques and electromyography. …”
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“…These findings suggest an avenue for modernizing the ubiquitous questionnaire and ultimately opening doors to a greater understanding of the human condition.…”
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“…Objective: Whether dietary carbohydrate (CHO) or fat is more involved in type 2 diabetes (T2DM) induction uncomplicated by dietary fiber was addressed in a spontaneous diabetic model, the diurnal Nile rat that mimics the human condition. Methods: A total of 138 male Nile rats were fed plant-based and animal-based saturated fat where 10% energy as CHO and fat were exchanged across 5 diets keeping protein constant, from 70:10:20 to 20:60:20 as CHO:fat:protein %energy. …”
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“…The interventions imagined and imposed in response, have largely shaped these unbalanced relationships which, I assert, closely follow the features of James Scott’s high-modern state projects (Scott 1998, Seeing Like a State: How Certain Schemes to Improve the Human Condition Have Failed). Through this, an articulation of the tension between the Indian state and two transhumant pastoral communities—the Gaddis and the Van Gujjars—will be attempted to be juxtaposed and contrasted. …”
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“…At present, the porcine model of AMI is used most frequently as it mimics the human condition and its anatomopathological features accurately. …”
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“…Except in very exceptional conditions, lipotoxicity caused by free fatty acids and bile acid toxicity caused by bile acid always coexist in the NAFLD human condition. In this respect, we believe that inhibiting HNF4α is more effective as a therapeutic strategy for NAFLD. …”
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“…In contrast to humans, neuromelanin does not appear spontaneously in most animals, including rodents, and Parkinson’s disease is an exclusively human condition. Using humanized neuromelanin-producing rodents, we recently found that neuromelanin can trigger Parkinson’s disease pathology when accumulated above a specific pathogenic threshold. …”
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“…PURPOSE: Although flatfoot is a widespread human condition, historical medical texts and ancient illustrations on this deformity are extremely rare. …”
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“…Variants in GLRA1 are known to cause hereditary hyperekplexia in humans; however, this is the first study to associate a variant in canine GLRA1 with the disorder, establishing a spontaneous large animal disease model for the human condition. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00439-023-02571-z.…”
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“…This is the first description of the neuropathology of human obesity and when combined with its reconstitution in a mouse model suggests adaptive immunity may drive as much as 40% of the human condition. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40478-023-01659-x.…”
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“…Elevated astrocytic MAO-B mimicking age related increase resulted in specific, selective and progressive loss of dopaminergic neurons in the substantia nigra (SN), the same subset of neurons primarily impacted in the human condition. This was accompanied by other PD-related alterations including selective decreases in mitochondrial complex I activity and increased mitochondrial oxidative stress. …”
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“…Many of these conditions are modelled, pre-clinically, in the guinea pig due to similar disease onset and progression to the human condition, and their generally well-characterised anatomy. …”
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“…How well a model recapitulates the human condition and the ease and reproducibility of data collected will determine how much confidence a scientist can place on results obtained. …”
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“…Of these, knock-in models best mimic the human condition from a genetic perspective since they express the mutation in the appropriate genetic and protein context. …”
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“…The clinical presentation of contact lens–associated Fusarium keratitis in the rat model is similar to the human condition. SD-OCT is a valuable tool that non-invasively revealed characteristic signs of the fungal infection and could provide sensitive, objective monitoring in fungal keratitis.…”
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