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Mostrando 401 - 420 Resultados de 722 Para Buscar '"human condition"', tiempo de consulta: 0.66s Limitar resultados
  1. 401
    “…RESULTS: Excess PP(i) in the Alpl(−/−) mouse inhibited cementum formation, causing root detachment consistent with premature tooth loss in the human condition hypophosphatasia, though cementoblast phenotype was unperturbed. …”
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    Central Role of Pyrophosphate in Acellular Cementum Formation
  2. 402
    por Singh, Ajai R.
    Publicado 2014
    “…Such differences are only manifestations of an intricate network of influences that make for the human condition in health and disease. Psychiatry is the one branch which realises this diversity the most, but equally important for it is to stress its unity: 1. …”
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    Shrug Ambivalence and Disagreement; Search Commonalities in Psychiatric Phenomena(**)
  3. 403
    “…Outcomes were compared with human condition to validate the model. To confirm graft survival, green fluorescent protein (GFP) mice were used, and histologic analysis was performed to differentiate between ear and back skin. …”
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    A novel immune competent murine hypertrophic scar contracture model: A tool to elucidate disease mechanism and develop new therapies
  4. 404
    “…With underlying physiology potentially representative of the human condition and the ability to affect outcome measures of disease using pharmacotherapy, this model represents a unique opportunity to further our understanding of the biology and treatment of SIB in both animals and humans.…”
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    Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior
  5. 405
    “…The mouse model, in particular, does not represent the human condition. We urge caution in applying findings in murine models to septic patients, both with regard to our understanding of pathophysiology and the failure to translate preclinical efficacy into successful clinical trials. …”
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    The metabolic phenotype of rodent sepsis: cause for concern?
  6. 406
    “…To better understand the role that this metabolite cluster plays in obesity-related metabolic dysfunction, we studied the impact of BCAA restriction in a rodent model of obesity in which BCAA metabolism is perturbed in ways that mirror the human condition. METHODS: Zucker-lean rats (ZLR) and Zucker-fatty rats (ZFR) were fed either a custom control, low fat (LF) diet, or an isonitrogenous, isocaloric LF diet in which all three BCAA (Leu, Ile, Val) were reduced by 45% (LF-RES). …”
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    Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export
  7. 407
    “…The logic of the proposed Research for Impact Tool is based on the understanding that the value of research is to create evidence and/or products to support smarter decisions so as to improve the human condition. Research is, therefore, of limited value unless the evidence created is used to make smarter decisions for the betterment of society. …”
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    Evaluating Research Impact: The Development of a Research for Impact Tool
  8. 408
    “…The model utilizes immunocompetent animals from wild-type FVB/NJ and C57BL/6J strains, providing a better analogy to the human condition than approaches involving immunodeficient, genetically modified animals, or direct ZIKV injection into the brain. …”
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    Hydrocephalus and arthrogryposis in an immunocompetent mouse model of ZIKA teratogeny: A developmental study
  9. 409
    “…Functional near-infrared spectroscopy was utilized to simultaneously measure hemodynamic signals representing neural activity in pairs of subjects playing poker against each other (human–human condition) or against computer opponents (human–computer condition). …”
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    Distributed Neural Activity Patterns during Human-to-Human Competition
  10. 410
    “…Spinal cord injury is also common in pet dogs and requires new effective therapies, meaning that they can act as a translational model for the human condition while also deriving direct benefits from such research. …”
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    Pharmacokinetics and safety of oral glyburide in dogs with acute spinal cord injury
  11. 411
    “…METHODS: A hyperandrogenised PCOS mouse model was used that mimics the ovarian, endocrine and metabolic features of the human condition. Immunohistochemistry and digital image analysis were used to investigate and compare fibrinolytic/proteolytic markers plasminogen, plasminogen/plasmin, tissue plasminogen activator, urokinase plasminogen activator and inhibitor PAI-1 in PCOS and control ovaries. …”
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    Expression of the plasminogen system in the physiological mouse ovary and in the pathological polycystic ovary syndrome (PCOS) state
  12. 412
    “…These findings are consistent with human COVID-19 further demonstrating that the AGM faithfully reproduces the human condition.…”
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    Intranasal exposure of African green monkeys to SARS-CoV-2 results in acute phase pneumonia with shedding and lung injury still present in the early convalescence phase
  13. 413
    “…However, our clinically relevant animal model with congenital hernia closely resembles the clinical human condition. Further studies should be focused on this valuable animal model to evaluate stem cell therapies in hernia surgery.…”
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    Laparoscopy for the Treatment of Congenital Hernia: Use of Surgical Meshes and Mesenchymal Stem Cells in a Clinically Relevant Animal Model
  14. 414
    “…Importantly, B cells delivered intraperitoneally either remain within the peritoneal cavity in a quiescent state, despite the presence of dividing T cells, or migrate to lymphoid tissues where they actively divide; this dichotomy mimics the human condition in that cells in primary lymphoid tissues and the blood are predominately resting, whereas those in secondary lymphoid tissues proliferate. …”
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    A Detailed Analysis of Parameters Supporting the Engraftment and Growth of Chronic Lymphocytic Leukemia Cells in Immune-Deficient Mice
  15. 415
    “…We demonstrate the efficacy and safety of our approach in a preclinical murine model that phenotypically resembles the human condition, thus presenting a potential therapy that could have a significant therapeutic impact on the treatment of GSD1a.…”
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    mRNA therapy restores euglycemia and prevents liver tumors in murine model of glycogen storage disease
  16. 416
    “…SIMPLE SUMMARY: We lack studies investigating mitochondrial metabolism in the prenatal and early postnatal period in humans, but parallel experiments conducted in a mammalian system are informative about the human condition. Our aim was to study the perinatal metabolic switch in rats—an extremely complex process, associated with tissue proliferation and differentiation together with a rapid oxidative stress response (using techniques including microarrays, qPCR, spectrophotometry and high-performance liquid chromatography). …”
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    Microarray and qPCR Analysis of Mitochondrial Metabolism Activation during Prenatal and Early Postnatal Development in Rats and Humans with Emphasis on CoQ(10) Biosynthesis
  17. 417
    “…Exposure to western-style diet (WSD), high in both fats (45% kcal) and carbohydrates (35% kcal): e.g., high fat diet (HFD), has been linked to the development of metabolic syndrome-like symptoms and behavioral dysregulation in rodents, as similarly observed in the human condition. Because adolescence is a developmental period highlighted by vulnerability to both stress and poor diet, understanding the mechanism(s) underlying the combined negative effects of WSDs and stress on mood and reward regulation is critical. …”
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    Exposure to Vicarious Social Defeat Stress and Western-Style Diets During Adolescence Leads to Physiological Dysregulation, Decreases in Reward Sensitivity, and Reduced Antidepressant Efficacy in Adulthood
  18. 418
    “…Last, to determine whether the findings in GFAP(Tg);Gfap(+/R236H) mice are present in the human condition, AxD patient and control samples were analyzed by Western blot, which indicated that Type I AxD patients have a significant fourfold upregulation of FABP7. …”
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    Metabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of Alexander Disease With Severe Reactive Gliosis
  19. 419
    por Navarro Bonilla, Diego
    Publicado 2011
    “…The themes of love and death, understood as extremes of the human condition, engender writing practices that attempt to bridge the gap between the absent and the living. …”
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    Archival context and records of feelings regarding love and death in the modern and contemporary ages: a proposal for integration from the perspective of Social History of Written Culture
  20. 420
    “…The house dust mite (HDM) sheep asthma model displays many features of the human condition and is an ideal model to further elucidate the involvement of these critical Th(2) cytokines. …”
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    Dynamics of IL-4 and IL-13 expression in the airways of sheep following allergen challenge
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