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Mostrando 421 - 440 Resultados de 722 Para Buscar '"human condition"', tiempo de consulta: 0.34s Limitar resultados
  1. 421
    “…The results should be interpreted with caution, as results from animal models do not necessarily directly translate in human condition.…”
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    Does Long-Term High Fat Diet Always Lead to Smaller Hippocampi Volumes, Metabolite Concentrations, and Worse Learning and Memory? A Magnetic Resonance and Behavioral Study in Wistar Rats
  2. 422
    “…In contrast, naturally occurring canine epilepsy is similar to the human condition and can serve as a platform to translate research from rodents to humans. …”
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    Intravenous Topiramate: Pharmacokinetics in Dogs with Naturally Occurring Epilepsy
  3. 423
    “…Specific challenges identified and discussed in the application of embodied AI include: matters of risk-assessment, referrals, and supervision; the need to respect and protect patient autonomy; the role of non-human therapy; transparency in the use of algorithms; and specific concerns regarding long-term effects of these applications on understandings of illness and the human condition. CONCLUSIONS: We argue that embodied AI is a promising approach across the field of mental health; however, further research is needed to address the broader ethical and societal concerns of these technologies to negotiate best research and medical practices in innovative mental health care. …”
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    Your Robot Therapist Will See You Now: Ethical Implications of Embodied Artificial Intelligence in Psychiatry, Psychology, and Psychotherapy
  4. 424
    “…In both human and rat islets, we found that selective sst5 agonists potently suppressed insulin secretion more effectively than selective sst2 or sst3 agonists, while having little effect on glucagon secretion, demonstrating their potential efficacy in the human condition. These studies support our program to identify and develop potent nonpeptide selective sst5 agonists with pharmaceutical and safety characteristics suitable for evaluation in human clinical trials.…”
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    SAT-260 Selective Nonpeptide Somatostatin Subtype 5 (sst5) Agonists Suppress Induced Insulin Secretion in Pancreatic Islets from both Rats and Healthy Human Donors
  5. 425
    “…Alternatively mice with plaque without APP(SwInd) expression resemble the human condition of sporadic Alzheimer’s, and had better transport. …”
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    Decoupling the Effects of the Amyloid Precursor Protein From Amyloid-β Plaques on Axonal Transport Dynamics in the Living Brain
  6. 426
    “…Models of Shared Socioeconomic Pathway scenarios (SSPs) projected to 2050 and 2100 showed that whereas practices of increasing inequality (SSP4) or unconstrained growth in economic output and energy use (SSP5) are projected to have dire consequences for human well-being and primate survivorship, practices of sustainability-focused growth and equality (SSP1) are expected to have a positive effect on maintaining biodiversity, protecting environments, and improving the human condition. These results stress that improving the well-being, health, and security of the current and future human populations in primate range countries are of paramount importance if we are to move forward with effective policies to protect the world’s primate species and promote biodiversity conservation.…”
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    Current and future trends in socio-economic, demographic and governance factors affecting global primate conservation
  7. 427
    “…Factors that contribute to this crisis of translation include poor representation by preclinical models of the complex human condition of sepsis, bias in preclinical studies, as well as limitations of single-laboratory methodology. …”
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    National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research
  8. 428
    “…PDXs better recapitulate the human condition, and these studies were designed to gather robust data for translation to a clinical trial. …”
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    Targeting High-Risk Neuroblastoma Patient-Derived Xenografts with Oncolytic Virotherapy
  9. 429
    “…While the consequences of NRXN1 deletion have been extensively studied on the synaptic and behavioral levels, circuit endophenotypes that translate to the human condition have not been characterized yet. Therefore, we investigated the electrophysiology of cortico-striatal-thalamic circuits in Nrxn1α(−/−) rats and wildtype littermates focusing on a set of translational readouts, including spontaneous oscillatory activity, auditory-evoked oscillations and potentials, as well as mismatch negativity-like (MMN) responses and responses to social stimuli. …”
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    Neurexin1α knockout rats display oscillatory abnormalities and sensory processing deficits back-translating key endophenotypes of psychiatric disorders
  10. 430
    “…In 1997, our laboratory generated GH receptor gene-disrupted mice (GHR−/−), a mouse model of GH resistance that resembles the human condition termed Laron Syndrome (LS). These mice have provided countless insights into the numerous actions of GH. …”
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    MON-LB018 Depot-Specific Differences in Adipose Tissue Morphology with Laron Syndrome
  11. 431
    “…METHODS: To address the complexity of the human condition, the Renal Community Photo Initiative offered participants an array of diverse and accessible image-making techniques. …”
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    The Renal Community Photo Initiative: A Program Report in Ontario, Canada
  12. 432
    “…We introduced diabetic cataract in the Nile grass rat (NGR) that spontaneously develops type 2 diabetes (T2D) and showed its closeness to the human condition. Specialized stereo microscopy with dual bright-field illumination revealed novel hyperreflective dot-like microlesions in the inner cortical regions of the lens. …”
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    Pre-hyperglycemia immune cell trafficking underlies subclinical diabetic cataractogenesis
  13. 433
    “…Notably, DA2B flies showed dramatically stronger phenotypic defects compared to DA1 flies, mirroring the human condition. Mechanical studies of indirect flight muscle fibers from DA1 heterozygotes revealed reduced power output along with increased stiffness and force production, compared to wild-type controls. …”
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    Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism
  14. 434
    “…Our models accurately mimic the human condition and provide unique insights into RRD tumorigenesis, allowing optimization of subgroup-tailored therapeutic approaches.…”
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    BIOL-18. NEWLY DEVELOPED REPLICATION REPAIR DEFICIENT (RRD) MOUSE MODELS PROVIDE INSIGHTS INTO MEDULLOBLASTOMA/GLIOMAGENESIS AND RESPONSE TO IMMUNOTHERAPY
  15. 435
    “…Furthermore, we have focussed on phenotypes in young adult animals, whilst the human condition associated with NLGN3 mutations appears during the first few years of life. …”
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    Imbalance of flight–freeze responses and their cellular correlates in the Nlgn3(−/y) rat model of autism
  16. 436
    “…Pigs have become attractive biomedical models for human condition due to similarities in anatomy, physiology, and metabolism relative to humans, which could serve as an appropriate model for Laron syndrome. …”
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    Generation of GHR-modified pigs as Laron syndrome models via a dual-sgRNAs/Cas9 system and somatic cell nuclear transfer
  17. 437
    “…One of the most valid and used animal models for AN is the activity-based anorexia (ABA), which recapitulates important features of the human condition. This model is generated from naïve rodents by a self-motivated caloric restriction, where a fixed schedule food delivery induces spontaneous increased physical activity. …”
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    Activity-based anorexia animal model: a review of the main neurobiological findings
  18. 438
    “…Zebrafish (Danio rerio) have emerged as a powerful model to study the gut microbiome in the context of human conditions, including hypertension, cardiovascular disease, neurological disorders, and immune dysfunction. …”
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    Small fish, big discoveries: zebrafish shed light on microbial biomarkers for neuro-immune-cardiovascular health
  19. 439
    por Söderlund, Johan, Lindskog, Maria
    Publicado 2018
    “…Specifically, we suggest similarities between triggers of depressive-like behavior in animal models and human conditions known to increase the risk of depression, for example exhaustion and bullying. …”
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    Relevance of Rodent Models of Depression in Clinical Practice: Can We Overcome the Obstacles in Translational Neuropsychiatry?
  20. 440
    por Wassenaar, Trudy M.
    Publicado 2016
    “…Since then, one of these strains became the most frequently used probiotic E. coli in research and was applied to a variety of human conditions. Here, properties of that E. coli Nissle 1917 strain are compared with other commercially available E. coli probiotic strains, with emphasis on their human applications. …”
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    Insights from 100 Years of Research with Probiotic E. Coli
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