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Mostrando 481 - 500 Resultados de 722 Para Buscar '"human condition"', tiempo de consulta: 0.37s Limitar resultados
  1. 481
    por Kim, Jihyun, You, Sooseong
    Publicado 2021
    “…Samul-tang (SM), a traditional herbal medicine, is used to treat age-related human conditions, such as infertility and menstrual irregularities. …”
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    Effect of samul-tang on female fertility via RAS signaling pathway in ovaries of aged mice
  2. 482
    “…In this review, we present the biological and clinical impacts of this species on a range of human conditions beginning in neonatal life and beyond. …”
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    Efficacy of Bifidobacterium longum alone or in multi-strain probiotic formulations during early life and beyond
  3. 483
    “…This study presented a rapid production of pulmonary organoids using a multi-germ-layer approach that could be used for studying respiratory-related human conditions.…”
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    Rapid Generation of Pulmonary Organoids from Induced Pluripotent Stem Cells by Co-Culturing Endodermal and Mesodermal Progenitors for Pulmonary Disease Modelling
  4. 484
    “…Natural mutations in complement molecules highlight their requirement in regulation of a variety of human conditions including infectious disease and autoimmunity. …”
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    Complement, C1q, and C1q-Related Molecules Regulate Macrophage Polarization
  5. 485
    “…Entrainment of these novel oscillators by palatable snacks and timed exercise could become novel therapeutics for human conditions caused by disruptions of the circadian clocks.…”
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    Period-independent novel circadian oscillators revealed by timed exercise and palatable meals
  6. 486
    “…Given close similarities to humans, the NHP model offers exceptional opportunities to understand the biological mechanisms and translational applications with direct relevance to human conditions. Here, we evaluate the opportunities and limitations of NHPs as animal models for translational regenerative medicine. …”
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    Nonhuman primate model in clinical modeling of diseases for stem cell therapy
  7. 487
    “…Nonetheless, more often than not mouse models do not reproduce the pathophysiology of the human conditions they are designed to mimic. Naturally occurring large animal models have predominantly been found in companion animals or livestock because of their emotional or economic value to modern society and, unlike mice, often recapitulate the human disease state. …”
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    Canine Models of Inherited Musculoskeletal and Neurodegenerative Diseases
  8. 488
    “…Finally, both the beneficial and detrimental effects of antioxidant molecules that are used to reduce oxidative stress in several human conditions are discussed.…”
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    Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases
  9. 489
    “…Numerous human conditions are associated with the microbiome, yet studies are inconsistent as to the magnitude of the associations and the bacteria involved, likely reflecting insufficiently employed sample sizes. …”
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    An atlas of robust microbiome associations with phenotypic traits based on large-scale cohorts from two continents
  10. 490
    por Tagliatti, Erica, Cortese, Katia
    Publicado 2022
    “…Thus, it is not surprising that both environmental and genetic perturbation of endocytosis have been associated with several human conditions such as cancer, neurological disorders, and virus infections, among others. …”
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    Imaging Endocytosis Dynamics in Health and Disease
  11. 491
    “…GH’s effects have been studied in human conditions of GH alteration, such as acromegaly and Laron syndrome, and GH therapies have been suggested to combat aging-related musculoskeletal diseases, in part, because of the decline in GH levels with advanced age. …”
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    Musculoskeletal Effects of Altered GH Action
  12. 492
    “…MicroRNAs (miRNAs) consist of a class of highly conserved, short, single-stranded segments (18–25 nucleotides) of noncoding RNA that represent key gene-transcription regulators in physiological and pathological human conditions. However, their role in SGC development and progression is not completely clear. …”
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    MicroRNAs’ Crucial Role in Salivary Gland Cancers’ Onset and Prognosis
  13. 493
    “…These studies mechanistically link genes implicated in human conditions of melanocyte deficiency and reveal how a ubiquitous factor (YY1) gains lineage-specific functions by co-regulating gene expression with a lineage-restricted factor (M-MITF)—a general mechanism which may confer tissue-specific gene expression in multiple lineages.…”
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    YY1 Regulates Melanocyte Development and Function by Cooperating with MITF
  14. 494
    “…Mitochondrial disorders are a group of highly invalidating human conditions for which effective treatment is currently unavailable and characterized by faulty energy supply due to defective oxidative phosphorylation (OXPHOS). …”
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    Mitochondrial diseases caused by toxic compound accumulation: from etiopathology to therapeutic approaches
  15. 495
    “…Abnormal development of multiciliated cells is a hallmark of a variety of human conditions associated with chronic airway diseases, hydrocephalus and infertility. …”
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    Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis
  16. 496
    “…These mechanisms may potentially play a role in human conditions that result in aberrant NE differentiation, including NE hyperplasias and cancer.…”
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    Jagged and Delta-like ligands control distinct events during airway progenitor cell differentiation
  17. 497
    por Toth, Denes, Tamas, Andrea, Reglodi, Dora
    Publicado 2020
    “…The aim of this minireview is to summarize both the therapeutic and biomarker potential of the neuropeptide PACAP, as a novel possible target molecule presently being investigated in several human conditions including TBI, and with encouraging results in animal models of TBI.…”
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    The Neuroprotective and Biomarker Potential of PACAP in Human Traumatic Brain Injury
  18. 498
    “…Recent studies revealed the role of miRNAs as powerful biomarkers in disease diagnosis and for the development of innovative therapeutic applications in several human conditions, including intestinal diseases. In this review, we explored the literature and summarized the role of identified dysregulated fecal miRNAs in intestinal diseases, with particular focus on colorectal cancer (CRC) and celiac disease (CD). …”
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    Fecal microRNAs as Innovative Biomarkers of Intestinal Diseases and Effective Players in Host-Microbiome Interactions
  19. 499
    “…In this review, we aim at providing a comprehensive view of the genetic and acquired heterotopic ossification disorders by detailing the clinical and molecular features underlying the different human conditions in comparison with the corresponding, currently available mouse models.…”
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    Genetic and Acquired Heterotopic Ossification: A Translational Tale of Mice and Men
  20. 500
    “…The relatively large size and long lifespan of NuRabbits offer unique applications in regenerative medicine, cancer research, and the study of a variety of other human conditions, including immunodeficiency.…”
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    Development of the Nude Rabbit Model
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