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Mostrando 501 - 520 Resultados de 722 Para Buscar '"human condition"', tiempo de consulta: 2.13s Limitar resultados
  1. 501
    “…Here, we examine the familiar and emerging roles of VEGFR3 in the development of both lymphovascular and cardiovascular systems, respectively, compare how distinct genetic variants in FLT4 lead to two disparate human conditions, and highlight the research still required to fully understand this multifaceted receptor.…”
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    The physiological and pathological functions of VEGFR3 in cardiac and lymphatic development and related diseases
  2. 502
    “…In each case, phenotypes in Drosophila are compared to those in human conditions. In addition, we discuss antiviral drug screening in flies and how investigating virus–host interactions may lead to novel antiviral drug targets. …”
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    Drosophila as a Model for Human Viral Neuroinfections
  3. 503
    “…Intractable self-injury, aggressive, and other destructive behaviors are real human conditions. Contingent electric skin shock (CESS) is a technology, based on behavior-analytic principles, used to ameliorate such behaviors. …”
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    Contingent Electric Skin Shock: An Empirical or Ideological Issue?
  4. 504
    “…The demonstration that replication-impaired, poorly competitive progenitor cell pools can promote tumorigenesis provides a new rationale for links between tumorigenesis and common human conditions of impaired DNA replication such as dietary folate deficiency, chemotherapeutics targeting dNTP synthesis, and polymorphisms in genes important for DNA metabolism.…”
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    Impaired DNA Replication within Progenitor Cell Pools Promotes Leukemogenesis
  5. 505
    “…Although these responses are probably the result of conditioning, direct evidence from human conditioning studies with physiological measures of motivational valence is rare. …”
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    Conditioned cues for smoking elicit preparatory responses in healthy smokers
  6. 506
    “…Alcohol abuse and dependence are human conditions for which no full equivalent exists in animals. …”
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    Who Is at Risk?: Population Characterization of Alcohol Self-Administration in Nonhuman Primates Helps Identify Pathways to Dependence
  7. 507
    “…However, their impact on the development and progression of major human conditions, from cancer to insomnia, metabolic or mental illness becomes increasingly apparent. …”
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    The ticking clock of Cayo Santiago macaques and its implications for understanding human circadian rhythm disorders
  8. 508
    “…Three-dimensional cell monolayer formation of human conditionally immortalized proximal tubule epithelial cells (ciPTEC) on biofunctionalized hollow fibers with maintained barrier function was demonstrated. …”
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    Bioengineered kidney tubules efficiently excrete uremic toxins
  9. 509
    “…Their presence in amygdala neurons may inform understanding of human conditions with amygdala dysfunction and deregulated reward pursuit. …”
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    Primate amygdala neurons evaluate the progress of self-defined economic choice sequences
  10. 510
    “…Specifically, partial inhibition of mitochondrial complex I has been exploited as a novel strategy for multiple human conditions, including AD, with several small molecules being tested in clinical trials. …”
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    Mitochondrial complex I as a therapeutic target for Alzheimer's disease
  11. 511
    “…BRD1 is also implicated in several human conditions and is a therapeutic target for cancer. …”
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    Hydrophobic cavity-directed azide-acetyllysine photochemistry for profiling non-histone interacting partners of bromodomain protein 1
  12. 512
    “…CUL4B is expressed in bone marrow MSCs (BMSCs) and downregulated with aging in mice and humans. Conditional knockout of Cul4b in MSCs resulted in impaired postnatal skeletal development with low bone mass and reduced bone formation. …”
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    CUL4B orchestrates mesenchymal stem cell commitment by epigenetically repressing KLF4 and C/EBPδ
  13. 513
    “…However, so far little is known about physiological functions of TMEM106B in the endolysosome and how TMEM106B is involved in a wide range of human conditions at molecular levels. Here, we performed lipidomic analysis of the brain of TMEM106B-deficient mice. …”
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    Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism
  14. 514
    por Naik, Edwina, Dixit, Vishva M.
    Publicado 2010
    “…TREATMENT OF AUTO-INFLAMMATORY DISORDERS: A number of human conditions are characterized by unrestrained inflammasome activation. …”
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    Modulation of Inflammasome Activity for the Treatment of Auto-inflammatory Disorders
  15. 515
    “…The bioartificial kidney (BAK) aims at improving dialysis by developing ‘living membranes’ for cells-aided removal of uremic metabolites. Here, unique human conditionally immortalized proximal tubule epithelial cell (ciPTEC) monolayers were cultured on biofunctionalized MicroPES (polyethersulfone) hollow fiber membranes (HFM) and functionally tested using microfluidics. …”
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    Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations
  16. 516
    por Barreiro, Esther
    Publicado 2016
    “…Future research will elucidate the specific impact and sites of reactive carbonyls on muscle protein content and function in human conditions.…”
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    Role of Protein Carbonylation in Skeletal Muscle Mass Loss Associated with Chronic Conditions
  17. 517
    “…Dogs commonly serve as a model for various human conditions, including periodontal diseases. The aim of this study was to identify the anaerobic bacteria that colonize the subgingival areas in dogs and humans by using rapid real-time polymerase chain reaction (RT-PCR)-based tests and to compare the results obtained in each species. …”
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    Molecular-level evaluation of selected periodontal pathogens from subgingival regions in canines and humans with periodontal disease
  18. 518
    “…We further discuss the functions of HA in the naked mole rat and compare them to human conditions. Though intensively researched, this simple polymer bears some secrets that may hold the key for a better understanding of cellular processes and the development of diseases, such as cancer.…”
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    A Trickster in Disguise: Hyaluronan’s Ambivalent Roles in the Matrix
  19. 519
    “…These findings may provide insights toward the KU molecular mechanisms, which have been related to telomere maintenance, apoptosis, DNA replication, and gene transcription regulation, as well as associated human conditions including immune system disorders, cancer, and aging.…”
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    mus-52 disruption and metabolic regulation in Neurospora crassa: Transcriptional responses to extracellular phosphate availability
  20. 520
    “…Further, laboratory hamsters develop a variety of inherited diseases, which display similarities to human conditions. Hamsters possessing some of these inherited traits are commercially available. …”
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    The Experimental Use of Syrian Hamsters
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