“…We administered a survey to determine consumers’ attitudes towards welfare certifications and the willingness to pay for foods from animals raised under more humane conditions. Most respondents (78%) thought it was important to know that animal-welfare assessments are conducted by an independent third party or the federal government (and not only the industry producer). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…IMPLICATIONS FOR PRACTICE: γ‐secretase has been proposed as a therapeutic target in numerous human conditions, including cancer. A better understanding of the structure and function of the γ‐secretase inhibitor (GSI) would help to develop safe and effective γ‐secretase–based therapies. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Unfortunately, efficacy in neuropathic pain models, which are a more suitable model for human conditions of chronic pain, had fewer results (only three studies). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Learning from previous failures, we mimicked human conditions (performing experiments in the presence of physiological uridine plasma levels) and looked for synergic combinations to boost apoptosis, including classical antileukemic drugs and dipyridamole, a blocker of the pyrimidine salvage pathway. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Hyperbaric oxygen therapy (HBOT) is commonly utilized for various human conditions with a low incidence of major adverse effects (0.002–0.035%). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Polygonatum kingianum (PK) is a deficiency-nourishing Chinese herbal medicine utilized as both medicine and food, and it has long been used to ameliorate human conditions associated with fatigue and aging over 2000 years in China. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To this end, CRISPR/Cas9 technology was applied to generate AAC3(−/−) human conditionally immortalized renal proximal tubule epithelial cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, in some cases, it may be desirable to use long-established rat models that closely mimic particular aspects of human conditions such as Parkinson's disease and the development of epilepsy following status epilepticus. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Thus, this study was aimed to investigate the effect of binge alcohol on the inflammatory liver disease in HIV transgenic rats as a model for simulating human conditions. Female wild-type (WT) or HIV transgenic rats were treated with three consecutive doses of binge ethanol (EtOH) (3.5 g/kg/dose oral gavages at 12-h intervals) or dextrose (Control). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Finally, variations in the lipid supplement composition enabled the development of Jurkat cells with different membrane fatty acid profiles characterising different physiological or pathological human conditions. CONCLUSIONS: Each leukocyte class has its own specific membrane fatty acid profile in vivo. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, our data indicate that Alu‐mediated rearrangements of the OPTN upstream region may represent a new source of affected alleles in human conditions. Evaluation of the upstream OPTN sequences in additional ocular and ALS patients may help to determine the role of this region, if any, in human disease.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…As methotrexate is cleared by renal excretion, we studied the effect of cetuximab on renal methotrexate handling. We used human conditionally immortalized proximal tubule epithelial cells overexpressing either organic anion transporter 1 or 3 (ciPTEC-OAT1/ciPTEC-OAT3) to examine OAT1 and OAT3, and the efflux pumps breast cancer resistance protein (BCRP), multidrug resistance protein 4 (MRP4), and P-glycoprotein (P-gp) in methotrexate handling upon EGF or cetuximab treatment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Chiari-like Malformation (CM) and secondary syringomyelia (SM), as well as their analogous human conditions, is a complex developmental condition associated with pain and accompanying welfare concerns. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Some hereditary retinal dystrophies in dogs are important not only because they lead to vision loss but also because they show strong similarities to the orthologous human conditions. Advances in in vivo non-invasive retinal imaging allow the capture of retinal cross-section images that parallel low power microscopic examination of histological sections. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In obesity and lipodystrophy, IR is “selective”, with lack of insulin signalingcausing hyperglycemia, but enhanced insulin signaling causing dyslipidemia and possibly hyperuricemia. Rare human conditions exist in which there is extreme, non-selective, IR impairing all insulin signalingpathways (e.g. mutations of the insulin receptor, INSR). …”
Enlace del recurso
Enlace del recurso

“…Animal models have advanced our understanding of mt-disease but their relevance to human conditions is often limited by their relatively low nuclear genetic diversity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Collectively, these data indicate that the CRC approach offers a novel solution to expanding hAECs in humanized conditions for future clinical uses, while retaining their primary phenotype. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Pantoea species of the family Erwiniaceae are well-known plant pathogens and animal and human conditional pathogens. Due to the widespread and continuous use of antimicrobials, multidrug-resistant strains continue to emerge, making clinical treatment difficult; therefore, there is an increasing need to clarify the mechanisms of drug resistance. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Damian is not concerned with the rights or wrongs of religious myths amid the advancement of medicine and its adherence to science and reason, but with the attempt at a deep and broad understanding of human diseases and human conditions of being prone to such diseases throughout life.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The novel ketone diet, therefore, improved physical performance and cognitive function in rats, and its energy-sparing properties suggest that it may help to treat a range of human conditions with metabolic abnormalities.—Murray, A. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso